The research of the Genomics Lab is interdisciplinary in its aims and technology. Keywords include transcription regulation, diagnostics, (functional) genomics, proteomics, DNA microarrays and bioinformatics. Besides making use of and developing tools arising from the availability of whole-genome sequences, traditional biochemical , molucular biology and molecular genetic approaches are equally important. For projects aimed at understanding how the activity of genes is regulated (transcription regulation), the budding yeast S. cerevisiae is the most widely used model organism in the laboratory.| Research themes include:| - understanding mechanisms of genome-wide transcription regulation| - developing bioinformatic approaches for mining genome-wide data sets| - DNA microarray diagnostics| - microarray technology development.
The laboratory was founded with a grant from the UMC Utrecht GenVlag program, is part of the Department of Physiological Chemistry and houses the Utrecht University Academic Biomedical Centre (ABC) microarray facility.