KNAW

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Organisation

The Netherlands Cancer Institute

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Current research

(the most recent research is at the top)
Collaboration Modularity and complex interaction in cancer
Collaboration Pathway-based integration of multi-modal data sets for cancer biomarkers
Collaboration Structured life review using autobiographical retrieval practice in depressed palliative head and neck cancer and lung cancer patients
Collaboration Inhibitors of the human kinase PKB/Akt: conceptually new antibiotics
Collaboration Neoadjuvant drug treatment for Breast CAncer-REsponse-prediction and response monitoring (BREAST CARE)
Collaboration A new view on the connection between E-cadherin and the cytoskeleton
Collaboration Nano Imaging under Industrial Conditions (NIMIC)
Collaboration Functional screens
Commissioner The effect of the tumor microenvironment on radioresistance of breast cancer
Financier The regulatory role of Ubl domains in ubiquitin specific protease function
Financier Molecular Immunotherapy of HPV16-induced Cancer in combination with Chemotherapy
Secretariat Imaging agents for surgical guidance
Secretariat Spatial/temporal regulation of the Estrogen Receptor transcription complex and its role in breast cancer
Secretariat Oligonucleotide-directed gene targeting: evading mismatch repair
Secretariat Predicting and targeting primary chemotherapy resistance in conditional mouse models of breast cancer
Secretariat Oligonucleotide-directed gene modification in human induced pluripotent stem cells
Secretariat Motor proteins in spindle assembly: targets for cancer therapy?
Secretariat Intravital imaging and computational modeling of skin immunity
Secretariat Analgesia and nerve function following pulsed radiofrequency
Secretariat Cancer cell-intrinsic and -extrinsic regulation of breast cancer metastasis formation; implications for adjuvant therapy
Secretariat Molecular dissection of ATR activation
Secretariat Control of chromosome architecture by nuclear lamins: role in laminopathies.
Secretariat Resistance to PARP inhibitors: assocciation with DNA damage response alterations
Secretariat Analysis of minimal residual disease and therapy resistance in primary tumor xenograft models of triple-negative breast cancer
Secretariat Optimizing Nasopharyngeal Carcinoma management through increasing awareness in Yogyakarta, Indonesia (ONMAY)
Secretariat A phosphoproteomic approach to uncover regulators of checkpoint recovery
Secretariat Regulation of H2A ubiquitination
Secretariat Systemic approach to define the MHC class I and II modifying secretome
Secretariat The role of nuclear lamina in oncogene-induced senescence and cancer progression
Secretariat A critical role for WHSC1 at telomeres
Secretariat Large Scale Peptide Synthesis and Purification
Secretariat The blueprint of breast cancer
Secretariat Finding readers that can decipher the epigenetic language of the chromatin core
Secretariat Multispectral nanomaterials for image guided surgery
Secretariat Initiation of DNA mismatch repair
Secretariat Mechanical control of chromatin organization and gene expression
Secretariat p53 and cancer cell metabolism
Secretariat RNA interference screens to identify determinants of sensitivity to mitotic kinase inhibitor
Secretariat Linking the dynamics of dendritic cell - T cell interactions to T cell receptor signaling and T cell differentiation
Secretariat Tracing and mapping of genome-nuclear lamina interactions in single cells
Secretariat Autotaxin, a secreted phosphodiesterase with diverse roles in disease: structural and functional studies
Secretariat Cohesin loading and stripping: two fundamental principles for the maintenance of genomic stability
Secretariat Assessment of late effects of treatment for Hodgkin's lymphoma
Secretariat Validation of autotaxin, a metastasis-enhancing exo-phosphodiesterase, as a therapeutic target
Secretariat Deciphering the Role of Bmi1 and Ezh2 Polycomb group genes in Prostate Carcinogenesis and Metastasis
Secretariat A randomized trial comparing longstanding indewelling pleural catheters with pleurodesis as a frontline treatment for malignant pleural effusion.
Secretariat Image guided Preoperative Accelerated Partial Breast Irradiation (PAPBI): defining radiotherapy sensitivity.
Secretariat An online testing approach to assess cognitive problems associated with cancer and cancer treatment
Secretariat Tumor-specific radiosensitization by exploiting base excision repair deficiencies
Secretariat The application of neuroimaging techniques in studying cognitve impaiments and complaints after chemotherapy
Secretariat Detecting errors in protein production in cancer cell lines
Secretariat Modifiers of tumor development in Lynch syndrome
Secretariat Dose-escalation by boosting radiation dose within the primary tumor on the basis of a pre-treatment FDG-PET-CT scan in stage II and III NSCLC: A randomized phase II trial
Secretariat Identification of potential drug targets in acute lymphoblastic leukaemia by functional genomics.
Secretariat A systems biology approach to construct computational models for predicting response to therapy in breast cancer
Secretariat Identification of targets of Cdc14 that are essential for cytokinesis
Secretariat Using high-throughput screening of chemical libraries to identify factors involved in cross-presentation
Secretariat Impact of CD27-CD70 co-stimulation on effector development of CD4 T cells
Secretariat How proteoglycan receptors affect antigen cross-presentation and immunity
Secretariat DNA damage repair in the cell
Secretariat The molecular mechanism of the degradation of large molecular complexes
Secretariat The role and function of ERAAP in HLA-B27-mediated onset of Ankylosing Spondylitis
Secretariat The search for predictive markers in the treatment of breast cancer patients
Secretariat Pan-DUB inhibitors to delineate DUB dependent biology and tools to study the ubiquitinated proteome
Secretariat Functional analysis of PTEN, SOX4 and PML in prostate cancer development and progression
Secretariat A novel type of ubiquitination regulates apoptosis signaling by BH3-only protein Bid.
Secretariat Nuclear lamina - genome interactions in mammalian cells
Secretariat Short-chain sphingolipids for enhanced cellular uptake of amphiphilic anti-cancer drugs
Secretariat MINDACT: Microarray In Node-negative Disease may Avoid Chemo Therapy
Secretariat Image guided radiotherapy for breast cancer
Secretariat Cardiovascular morbidity and mortality in breast cancer survivors
Secretariat Identification of psychosocial problems and perceived need for support in cancer genetics
Secretariat Divergent Control of Cyclin B1-Cdk1 in Cancer Cells: a Key Role in Therapy
Secretariat A cancer genome atlas of the activation-induced cytidine deaminase: novel insights into the pathogenesis and prognosis of b cell lymphoma
Secretariat Impact of TRAIL death receptor trafficking on pro-apoptotic signaling
Secretariat Identification of enzymes involved in regulatory ubiquitination in TNF a--stimulated signalling by loss-of-function screens
Secretariat T cell programming at the dendritic cell interface: impact on anti-tumor immunity
Secretariat Understanding resistance to HER2-targeting therapy in human breast cancer through functional genetics
Secretariat A mouse stem cell model for skin cancer: Dual role of the integrin a6B4 in tumor initiation and progression
Secretariat Generation of human tumor specific T cells with high affinity T cell receptors
Secretariat Ascertaining the role of Myc in mouse mammary tumorigenesis
Secretariat Regulation of homologous recombination by the interaction between the MRN complex and Ctp1
Secretariat Self-renewal in normal and cancer breast stemcells
Secretariat Maintenance of genome integrity by histone (de)ubiquitinating enzymes
Secretariat Potential oncogens and functioning of gene-receptor TBX2
Secretariat A multifunctional genome-wide screen to unravel the roles of the conserved epigenetic regulator Dot1 in chromosome organization
Secretariat Synthetic lethality: a novel tactic for selective anticancer drug target discovery
Secretariat The role of class I HDACs in normal physiology, tumorigenesis and transcriptional regulation
Secretariat Manipulating the MHC class II system to control immune responses in autoimmunity
Secretariat Calcium and phosphoinositides in the control of podosome formation and tumor cell invasion
Secretariat Focus on the (HDAC) target
Secretariat Controlling hemidesmosome dynamics by phosphorylation of residues on the integrin b4 subunit
Secretariat Understanding prion strains and species barriers and devising novel diagnostic approaches
Secretariat Immunological and structural studies of prion diversity
Secretariat Development of a pre-clinical blood test for prion diseases
Secretariat Passage from intestine to brain: assessing the role of dendritic cells in capturing, expanding and disseminating prions
Secretariat Pre-clinical improvement of combined immunotherapy and chemotherapy for new variant Creutzfeld-Jacob disease
Secretariat Coordination of Cell Division by Regulated Protein Destruction

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