KNAW

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Organisation

Leiden Institute of Chemistry

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Current research

(the most recent research is at the top)
Collaboration Development of tyrosine kinase inhibotors
Collaboration Efficient development of small molecule inhibitorsof tyrosine kinases - Identification of EphA4 blockers as anti-cancer lead compounds
Collaboration Imagining Genomics: Introducing visuality in the genomics debate
Commissioner Evolution of organics in space: OREOCUBE in situ spectroscopy
Secretariat Molecular diagnostics; Overcoming target inhibition in nucleic acid-templated ligation reactions
Secretariat Chemical biology of glucosylceramide metabolism: fundamental studies and clinical applications for Gaucher disease
Secretariat Automated synthesis of phosphate containing biopolymers
Secretariat Lanthexpress
Secretariat New Targets to Address Old Problems in Oncology
Secretariat Theoretical characterization and optimization of transition metal synthetic catalysts for water oxidation
Secretariat Positive control of cell division: from new concepts to molecular detail
Secretariat Synthetic methodology for well-defined ADP-ribosylated biomolecules
Secretariat Automated solid phase synthesis of teichoic acids
Secretariat Cyclitol-fused 1-H-Imidazoles and Triazoles : a new mechanism-based class of glycosidas
Secretariat Towards accurate predictive calculations on reactions of molecules on metal surfaces
Secretariat Bio-inspired molecular rectifier for artificial photosynthesis
Secretariat AIMD calculations on hydrogen-copper scattering
Secretariat Computational electrochemistry
Secretariat Elucidating the catalytic properties of gold by electrochemistry
Secretariat Protein Motions Revealed by Paramagnetic NMR Spectroscopy
Secretariat Dynamics of chemical reactions involving hydrogen
Secretariat Sortagging to dissect the ubiquitin pathway
Secretariat Tailoring structure formation in complex systems
Secretariat Quantum Pathways to Photosynthesis - Purpose-Driven Theoretical Chemistry for the Artificial Leaf
Secretariat Parallelization of the components of Crank for automated structure solution
Secretariat Zwitterionic oligosaccharides: charging the immune system
Secretariat Ab initio electrochemistry
Secretariat Quick purification of protein complexes for structural proteomics, using single walled carbon nanotubes
Secretariat Structural insights into two pathways for repair of UV-damaged DNA
Secretariat Inhibitors of the human kinase PKB/Akt: conceptually new antibiotics
Secretariat From substrate to biomarker: matriptase and hepsin as potential cancer biomarkers
Secretariat Shedding light on the movement of cells: Spatial and temporal control of protein functioning
Secretariat Breathing through a wire: electro-enzymology of Q-wired respiratory complexes
Secretariat Structure determination of sub-micron three-dimensional crystals of proteins and other highly radiation sensitive materials by electron diffraction
Secretariat Stereocontrol of glycosylations by oxacarbenium ions
Secretariat Molecular Imaging using targeted MR1 contrast agents
Secretariat The low-field solid-state photo-CIDNP effect
Secretariat Unveiling the invisible conformational landscape of cytochrome P450.
Secretariat Visualisation of the encounter state of protein complexes
Secretariat Synthetic tools to interfere with glucosylceramide metabolism: fundamental studies and therapeutical apllications
Secretariat Novel mechanisms in bacterial cell division: an integrated approach to unravel the septum localising complex of streptomycetes
Secretariat An alternate mechanism for methane conversion
Secretariat A Synthetic Streptomycete: Rational design of streptomycetes as efficient clinical drug and enzyme factories in industrial fermentations
Secretariat Unveiling the invisible conformational landscape of cytochrome P450
Secretariat Paramagnetic tracking of substrates through cytochromes P450
Secretariat Localizing a key protein in bacterial nucleoid organization and defining its interplay with transcription
Secretariat Formation mechanisms of key astrochemical ice components
Secretariat Probing the dynamics of surface-catalyzed reactions with scanning noise microscopy
Secretariat The role of excited electronic and vibrational states in reactions at surfaces
Secretariat New chemical tools to study protein:protein interactions
Secretariat Nieuwe biomoleculaire gereedschappen
Secretariat Hydrogen storage in nanoporous clathrate materials
Secretariat Art & Genomics
Secretariat Zooming in at active sites on a catalytic surface
Secretariat Common denominators involved in misfolding proteins and aggregation diseases
Secretariat Investigation of the electronic and protonic structure of the tetrapyrrole chromophore of phytochrome during its photocycle by solid-state NMR
Secretariat Stress Protection by Proline
Secretariat Operational Mechanisms of Photoreceptors and Antenna Complexes
Secretariat Mechanism of Photo-CIDNP in Solids
Secretariat Functional Mechanisms of Light-Driven Electron Pumps
Secretariat The antitumor activity of Bleomycin
Secretariat Natural and artificial photosynthesis
Secretariat DNA damage signaling, tumorigenesis and apoptin
Secretariat DNA damage signaling and keratinocyte homeostasis
Secretariat GG-NER: a specialized form of repair in keratinocytes
Secretariat DNA damage signaling in repair deficient keratinocytes
Secretariat Copper metabolism and copper homeostasis in bacteria
Secretariat Polynuclear platinum complexes and their cellular processing
Secretariat The search for new spin-crossover materials
Secretariat High-nuclearity metal clusters
Secretariat Coordination chemistry of Cu(II) compounds
Secretariat Mechanistic Studies on the Copper-Catalyzed Oxidation of Phenols
Secretariat Crystal Engineering: A Matter of Rational Ligand design
Secretariat New ligands based on the cyanuric chloride synthon to synthesize tungsten oxo compounds for oxygen-transfer catalysis
Secretariat Biomimetic Catalysis - Cu(II) complexes with N2O2 donor ligands as structural and functional mimic of the enzyme ‘Galactose Oxidase’
Secretariat Structure determination of trimeric viral fibre proteins and their receptors
Secretariat Directed evolution of glycosaminoglycan syntheses and glycosaminoglycan modifying enzymes.
Secretariat Scattering of highly vibrationally excited NO from Ag(111) and Cs/Ag(111): electronically adiabatic or not?

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