KNAW

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Organisation

Hubrecht Institute

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Completed research

(the most recent research is at the top)
Collaboration ZF-MODELS - Zebrafish Models for Human Development and Disease
Collaboration Bone Morphogenetic Proteins (BMPs) in renal response to injury: application of BMP-responsive element-reporter mice to monitor BMP-signalling in experimental renal fibrogenesis and its reversal
Collaboration Stem cells in development and disease
Collaboration Genetic uncoupling of pro-death versus pro-survival pathways downstream of the inflammatory response in heart failure
Collaboration Early differentiation choices in mouse development
Collaboration Wnt signaling and body axis formation
Collaboration Structure and Functional Organisation of the Cell Nucleus
Secretariat Neural stem cells in a presenilin model of familial AD
Secretariat De novo genome assembly of the flatworm Macrostomum lignano
Secretariat Zebrafish brain development and homeostasis
Secretariat Genome dynamics and stability
Secretariat Beta cell neogenesis and diabetes
Secretariat Regulation of Wnt secretion and gradient formation by the putative Wnt sorting receptor Wntless and the retromer complex
Secretariat Identification of BRCA2's genetic network and breast cancer drug targets via genome-wide RNAi in C. elegans
Secretariat Tumor metastasis: the role of acto-myosin contraction in the downregulation of E-cadherin-mediated cell-cell adhesion
Secretariat Valve morphogenesis - directing cardiac form and function
Secretariat Modeling Familial Alzheimer's Disease in Zebrafish
Secretariat A state-of-the-art genetic modifier screen in the rat to identify novel mechanisms mediating serotonin homeostasis and related behavioural abnormalities
Secretariat Validation and implementation of the Embryonic Stem cell Test as an animal-free alternative for developmental toxicity testing
Secretariat Switching genes in heart failure
Secretariat The role of SYNPO2L, a novel protein expressed in cardiac and skeletal muscle, in sarcomere formation and stabilization
Secretariat Genome-wide identification of genes acting in the double-strand break response pathways of C. elegans
Secretariat Genetics of Cardiac Development
Secretariat The effect of mutations in TP53 and interaction partners on interaction of TP53 with its DNA binding sites
Secretariat Vasculogenesis and osteogenesis in the zebrafish
Secretariat TCF factors, mediators of Wnt signaling in development and cancer
Secretariat Cdx genes and the molecular and cellular mechanisms driving extension of the embryonic axis in the mouse
Secretariat Bmp signaling is at the heart of vertebrate left-right asymmetry
Secretariat The expression and function of microRNAs in vertebrate embryonic development
Secretariat Biochemistry of RNA interference in C. elegans
Secretariat The Peutz-Jeghers tumour suppressor kinase LKB1 is a master regulator of polarity
Secretariat NFAT: a transcriptional platform for heart failure
Secretariat Molecular manoeuvres in the Wnt cascade
Secretariat The role of the Wnt pathway in vascular growth during development and after myocardial infarction
Secretariat A zebrafish model for the role of APC proteins in development and cancer
Secretariat Genomics in the zebrafish, a vertebrate model system for developmental and neural biology, combining forward and reverse genetics
Secretariat Redox Regulation of Receptor Protein-Tyrosine Phosphatases
Secretariat Hox, microRNAs and evolution
Secretariat Small RNAs and Argonaute proteins: key players in post-transcriptional gene silencing
Secretariat Stress regulation of growth and development
Secretariat Spatio-temporal framework for integrative analysis of zebrafish developmental studies
Secretariat Regulation of Wnt target gene expression in C. elegans
Secretariat Genetics of Mammalian Development
Secretariat Linking and mining spatiotemporal databases of gene expression patterns of developmental model systems
Secretariat Nuclear hormone receptors
Secretariat The regulation of protein kinase A activity during epithelial mesenchyme transition
Secretariat The interaction of p50, p65, and the glucocorticoid receptor
Secretariat Characterization of action potentials in (human) embryonic cardiac muscle cells
Secretariat Biophysics
Secretariat Functional genomics
Secretariat Early differentiation in mammalian development
Secretariat Aristaless-related homeobox genes and skeletal development
Secretariat Lineage restriction in mammalian development
Secretariat Wnts and worms: from nematodes to vertebrates
Secretariat Brain development in zebrafish
Secretariat Patterning the posterior neural plate
Secretariat Wnt/beta-catenin/Tcf signaling in early development
Secretariat Mouse Hox genes: establishment of their expression domains and regulation of pattern formation
Secretariat Signal transduction mechanisms in epithelium-mesenchyme transitions of embryonic and tumor cells
Secretariat Regulation of receptor protein-tyrosine phosphatase alpha in oncogenesis

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