| (the most recent research is at the top) |
| Collaboration |
Gene-immunotherapy for patients with prostate cancer |
| Collaboration |
Development & application of shRNA (short hairpin RNA) in cell based screening technologies |
| Collaboration |
The molecular mechanism of Atp8b1-deficiency |
| Collaboration |
Integrated analysis of melanoma-T cell interactions in situ; relevance for immunotherapy |
| Collaboration |
Stem cells in development and disease |
| Collaboration |
FDG-PET in patients with colorectal liver |
| Collaboration |
Immunological pathomechanisms in vitiligo: from breaking tolerance to autoimmunity |
| Collaboration |
Peptide and protein aggregation in vivo |
| Collaboration |
Design, synthesis and application of molecularly defined TLR ligand-antigen conjugates for optimal DC activation and specific T cell induction. |
| Collaboration |
Postlaryngectomy pulmonary physiology and tracheal climate and the influence of a heat and moisture exchanger (HME) |
| Collaboration |
The intelligibility of tracheoesophageal speech: analytic and rehabilitation study |
| Collaboration |
Information processing and brain activity after adjuvant chemotherapy in breast cancer patients |
| Financier |
Mitotic entry and exit: the rise and fall of cyclin-Cdk-Cks activity |
| Financier |
Signal transduction by small GTPases of the Ras family and by protein kinase B (PKB) |
| Financier |
Signal transduction by small GTPases of the Ras family |
| Secretariat |
Tracing T cell differentiation by genetic barcoding |
| Secretariat |
Genome wide search for DNA damage checkpoint functions in human cells |
| Secretariat |
Dissecting metabolic T-cell dysfunction in cancer |
| Secretariat |
Dissecting the telomere damage response |
| Secretariat |
Imaging agents for multimodal visualization of ductal carcinoma in situ (DCIS) |
| Secretariat |
Understanding the role of the microenvironment in cancer stem cell generation and function |
| Secretariat |
Generation and validation of cytochrome P450 3A knockout and transgenic mice as tools for improved drug development and research |
| Secretariat |
Molecular dissection of AIRE (autoimmune regulator) -driven ectopic antigen expression |
| Secretariat |
Functional characterisation of E-cadherin signalling in breast cancer progression and metastasis. |
| Secretariat |
Development and characterization of models of spontaneous brain tumours |
| Secretariat |
Treatment of HPV positive penile and cervical cancer by induction of HPV E7-specific T cell immunity through DNA vaccination |
| Secretariat |
T cell receptor gene therapy of metastatic melanoma: a phase I clinical trial |
| Secretariat |
Targeting BMP and LRP5 signaling to control bone formation |
| Secretariat |
Prevention of trismus, swallowing and speech problems in patients treated with chemo-radiation for advanced head and neck cancer |
| Secretariat |
Genotyping as tool for dose individualisation in high-dose chemotherapy with cyclophosphamide, thiotepa and carboplatin |
| Secretariat |
Tailored preoperative chemotherapy in stage II and III breast cancer with either a primary tumor over 3 cm in size or a clinically tumor-positive axilla |
| Secretariat |
CD1 Trafficking and loading of Mycobaterium leprae lipids in maturing dentric cells |
| Secretariat |
Long-term risk of cancer after ovarian stimulation for in vitro fertilization |
| Secretariat |
FANCM, the mouse that roared |
| Secretariat |
Mechanisms of chemotherapy resistance in spontaneous tumors of genetically modified mice |
| Secretariat |
Genetic screens to identify cancer related functions of human microRNAs |
| Secretariat |
Image guided correction strategies to optimize the precision of radiotherapy |
| Secretariat |
Integrin-mediated regulation of Rho GTPases in control of tumor invasion |
| Secretariat |
Human melanocytic nevi: oncogene-induced senescence as a potential tumor-suppressing mechanism |
| Secretariat |
Dissection of the role of E-cadherin loss-of-function in breast cancer development and metastasis |
| Secretariat |
Structural and functional analysis of a novel E3 ubiquitin ligase consisting of the polycomb proteins Bmi1 and Ring1b (RNF2) |
| Secretariat |
Cognitive behavioral therapy (CBT) and physical exercise for climacteric symptoms in breast cancer patients experiencing treatment-induced menopause |
| Secretariat |
Automating 3D model building for biological macromolecules |
| Secretariat |
Exploring new uses of AChBP as model for ligand-gated ion channel research |
| Secretariat |
Whole genome analysis of the regulation of chromatin structure and gene expression |
| Secretariat |
Novel functional genomic screens to identify pathways that protect mouse and human cells against oncogenic transformation by mutant RAS |
| Secretariat |
Dynamic and static interactions between the nuclear lamina and the genome |
| Secretariat |
Molecular dissection of nuclear pathways in the nuclear pore complex in relation to nuclear export pathways |
| Secretariat |
L1 and Alu elements: structural and functional analysis of human non-LTR retrotransposons |
| Secretariat |
Structural and functional characterization of DNA mismatch repair protein complexes |
| Secretariat |
Exploring the zebrafish as a genetic model for cancer |
| Secretariat |
Inductively coupled plasma-mass spectrometry (ICP-MS) for the analysis of metal-based anticancer drugs in clinical samples |
| Secretariat |
Linking 3D clusterings of microarry data to gene loci and cellular functions |
| Secretariat |
Identification of BRCA1 mutation carriers in high-risk breast and ovarian cancer families using genetic profiling |
| Secretariat |
Autotaxin, a secreted lysophospholipase D: role in tumor progression |
| Secretariat |
TPPII and the role in antigen presentation by MHC class I molecules |
| Secretariat |
Mouse models for Small Cell Lung Cancer: Genotype-phenotype correlations as a basis to design better therapeutic intervention strategies |
| Secretariat |
Molecular basis of resistance to anti-estrogens in estrogen-receptor positive breast cancer |
| Secretariat |
Identification and characterization of human tumor suppressor genes in the p53 pathway |
| Secretariat |
PIP4K-beta/PtdIns5P/p53: A cellular stress regulated pathway and its implication in oncogenesis |
| Secretariat |
The role of the neurotrophic tyrosine kinase receptor TrkB in anoikis resistance, invasion and metastasis of human tumors |
| Secretariat |
A study of drug resistance mechanisms using large-scale RNA interference screens |
| Secretariat |
High precision radiotherapy in the presence of anatomical changes |
| Secretariat |
Lipid rafts as novel targets for anti-cancer therapy and induction of apoptosis |
| Secretariat |
Investigating the role of the Polycomb-group gene Bmi1 in medulloblastomas and in neural cancer stem cell maintenance |
| Secretariat |
The role of PRAME in oncogenesis |
| Secretariat |
Radiation-induced atherosclerosis: mechanisms and preventive intervention strategies |
| Secretariat |
The role of TGF[beta] and notch signaling in the development of radiation-induced telangiectasia |
| Secretariat |
Activity and distribution of proteasome inhibitors |
| Secretariat |
Psychosocial aspects of genetic testing in families at high risk of multiple tumors at various sites and ages |
| Secretariat |
Research into the way immune cells are trained to leave autologous tissues in peace |
| Secretariat |
Role of translesion DNA synthesis in immunity and cancer development |
| Secretariat |
Molecular mechanisms underlying CD27-CD70 costimulation |
| Secretariat |
Screening for cis-regulatory DNA elements of the Ink4a/ARF locus by means of Chromosome Conformation Capture (3C) |
| Secretariat |
Bypassing vaccination: cancer immunotherapy with ex vivo programmed T cells |
| Secretariat |
Dissecting the role of the 9p21 INK4 genes in development and tumor suppression in mouse models |
| Secretariat |
Subtle gene modification to study the role of the mismatch repair complex MSH2/MSH6 in mutation avoidance and tumor suppression |
| Secretariat |
Function of integrin-CD151 complexes in tumor cell invasion and metastasis |
| Secretariat |
Long-term psychosocial impact of genetic testing among familial adenomatous polyposis (fap) families |
| Secretariat |
DNA damage-induced disordered genes in tumours |
| Secretariat |
Mammary tumorigenesis in conditional tumor suppressor gene knockout mice: disease progression, gene discovery and cellular pathways |
| Secretariat |
Chemistry-based functional proteomics: new tools for immunology and cell biology |
| Secretariat |
Gene-environment interactions in BRCA1/2 breast/ovarian cancer families, a project of the Netherlands Collaborative Group on Hereditary Breast Cancer |
| Secretariat |
Manipulation of the CD70 locus to monitor and modulate the anti-tumor immune response and tumor development |
| Secretariat |
Application of Pathology-correlated Imaging to Improve the Accuracy of Surgery and Radiotherapy in Breast-conserving Therapy |
| Secretariat |
The role of RanBP3 in beta-catenin dependent nuclear signalling and oncogenesis |
| Secretariat |
Tumor therapy with ionizing radiation and death ligand trail: efficacy and key molecular determinants |
| Secretariat |
On the molecular mechanisms of cross-presentation and priming for an efficient anti-tumor immune response |
| Secretariat |
Molecular bar code screens to identify genetic interactions with protein kinases in mammalian cells |
| Secretariat |
Optimizing treatment of patients with Hodgkins lymphoma |
| Secretariat |
Tiam1/Rac signaling and Wnt/[beta]-catenin-induced tumorigenicity |
| Secretariat |
Purchase of X-ray diffraction equipment (X-ray mirrors, image plate, nitrogen cryo-stream) |
| Secretariat |
Structural and functional analysis of the human L1/Alu retroposition machinery |
| Secretariat |
Structural analysis of the mechanism of ubiquitin conjugation, a generalized cellular addressing system, that controls protein and DNA stability |
| Secretariat |
Antigen processing events in cross-presentation of exogenously acquired antigens |
| Secretariat |
mTHPC-mediated photodynamic therapy (PDT): how do drug uptake and distribution influence tumour and normal tissue response? |
| Secretariat |
Molecular analysis of the cytotoxic T cell response |
| Secretariat |
Modulation of cytochrome P450 (CYP) and P-glycoprotein (P-gp) and BCR activity in gut wall and liver as major determinants of poor oral bioavailability of anticancer drugs: preclinical and clinical studies |
| Secretariat |
Improvement of tumor response by combined modality treatment: a translational approach |
| Secretariat |
Hypoxia and perfusion in human tumors: quantification and implications for treatment outcome |
| Secretariat |
Role of diacylglycerol kinases in cell cycle progression and cytoskeletal organization |
| Secretariat |
The role of the forkhead transcription factor Trident in cell cycle control |
| Secretariat |
Regulation of the G2/M transition by extracellular factors |
| Secretariat |
The Insulin-like Growth Factor (IGF) system in breast and colorectal carcinogenesis: dietary intervention and molecular studies |
| Secretariat |
The incidence, nature and etiology of cognitive problems following chemotherapy for cancer |
| Secretariat |
Feasibility and limitations of T cell receptor gene transfer |
| Secretariat |
The use of novel pharmacodynamic end-points in early clinical trials: focus on farnesyltransferase inhibitors |
| Secretariat |
Optimization of conformal radiation therapy of non-small cell lung cancer by advanced 3-D planning and multi-modality imaging |
| Secretariat |
Image guided radiotherapy of bladder cancer |
| Secretariat |
Inclusion of geometric uncertainties in treatment planning for intensity modulated radiotherapy |
| Secretariat |
Determinants of radiosensitivity in mammalian cells: elucidating mechanisms using a putative dominant negative to DNA polymerase beta |
| Secretariat |
Compound Mrp2 (Abcc2) and other drug transporter knockout mice to study determinants of pharmacokinetics, toxicity risks and possible therapy optimization for anticancer drugs |
| Secretariat |
Studying tumorigenesis using siRNA-expressing vectors |
| Secretariat |
High throughput functional genetic screens for stable loss-of-function phenotypes in mammalian cells |
| Secretariat |
Isolation and functional analysis of novel genes that act in the p16INK4A-cyclin D-pRB-E2F pathway |
| Secretariat |
Oncogenic function of human DRIL1, a member of the ARID family of retinoblastoma protein-interacting factors |
| Secretariat |
Efficient in vitro genetic screens to identify new oncogenes involved in tumor progression |
| Secretariat |
Characterization of oncogenic potential and mechanism of gene-repression of TBX2 |
| Secretariat |
The role of BRCA1 and BRCA2 loss-of-function in breast cancer |
| Secretariat |
The identification of oncogenic events collaborating with loss of function of the retinoblastoma gene family in tumor development and progression |
| Secretariat |
Functional genomics of gene regulation by heterochromatin proteins |
| Secretariat |
A functional genomics approach to identify genes which influence tumor cell behavior in vivo |
| Secretariat |
Activated proteolysis, a novel rapid response to DNA damage |
| Secretariat |
Peptidases and improving the MHC class I immune response |
| Secretariat |
Improving anti-tumor immunity via TNF receptor family member CD27 and its ligand |
| Secretariat |
Role of LPA receptor signaling in cell migration, invasion, proliferation and tumorigenesis |
| Secretariat |
Cooperation between the Src oncogene and integrin alpha-v beta-3 in oncogenic transformation of epithelial cells |
| Secretariat |
Role of the chemokine SDF-1 and its receptor CXCR4 in carcinoma and melanoma metastasis |
| Secretariat |
Role of regulated exocytosis in migration, invasion and metastasis |
| Secretariat |
Characterization of a redox-regulated PtdIns (3,4,5) P3 synthesis pathways: implications for tumorigenesis |
| Secretariat |
Function-based screening for genes involved in invasion of epithelial tumor cells |
| Secretariat |
The role of survivin in cell cycle regulation and lymphomagenesis |
| Secretariat |
Pathological and molecular characteristics of tamoxifen-induced endometrial tumors |
| Secretariat |
Elucidation of the scavenging by ubiquitin |
| Secretariat |
Characterization of MRP3, a newly identified transporter of anti-cancer drugs |
| Secretariat |
Cloning of novel mammary tumor progression and metastasis genes |
| Secretariat |
Regulation of cadherin-mediated cell-cell adhesion by integrin signalling |
| Secretariat |
Integrin-associated proteins regulating migration and invasion |
| Secretariat |
Initiation and progression of lymphomas and skin carcinomas in Tiam1 mutant mice |
| Secretariat |
Subversion of TGF-beta/Smad signaling in cancer: analysis of TGF-beta receptor-initiated intracellular responses distinct from Smad activation |
| Secretariat |
Identification of the PIM regulatory network by microarray analysis and high throughput retroviral tagging in compound mutant mice |
| Secretariat |
Genetic profiling of tumors from patients with a genetic susceptibility for breast cancer |
| Secretariat |
The role of HLA-DO and HLA-DM in effective MHC class II-mediated immune activation |
| Secretariat |
Structure/function analysis of MutS homologs in hereditary non-polyposis colon cancer (HNPCC) |
| Secretariat |
Cancer susceptibility genes that predispose for radiation-induced breast cancer |
| Secretariat |
Clinical outcome of breast cancer in BRCA1 and BRCA2 carriers |
| Secretariat |
Self-nonself discrimination by tumor-specific CTL |
| Secretariat |
Physiological and pharmacological analysis of the novel multidrug resistance gene Bcrp (breast cancer resistance protein) using Brcp knockout mice |
| Secretariat |
Dose verification and dose optimization of radiotherapy using portal imaging |
| Secretariat |
Improvement of delineation quality in conformal radiotherapy through multi-modality imaging |
| Secretariat |
Communication to the mitochondria in apoptosis signaling by death receptors and DNA damaging regimens |
| Secretariat |
Design and clinical implementation of optimized irradiation techniques using static and dynamic intensity modulation |
| Secretariat |
Functional analysis of Bmi1-RING finger interacting proteins and application of microarray technology to identify Bm1-responsive genes |
| Secretariat |
Genetic screens to identify new components of the senescence/immortalization pathway |
| Secretariat |
Signal pathways controlling lymphoma dissemination |
| Secretariat |
Cell-cell communication and connexin signaling: suppression of cell transformation |
| Secretariat |
Specific and redundant functions of the retinoblastoma suppressor gene family in growth control and differentiation |
| Secretariat |
Identification and functional characterization of intracellular signaling proteins controlling transforming growth factor-beta-induced growth arrest |
| Secretariat |
Ras- and Rho signaling networks and epithelial-mesenchymal transition |
| Secretariat |
Control of survival, replication and differentiation of human T-cell precursors |
| Secretariat |
The role and mechanism of escape from Ras-induced senescence in oncogenesis |
| Secretariat |
The function of E2F transcription factors studied in vivo |
| Secretariat |
The regulation of the expression of hTERT, the catalytic subunit of telomerase, during immortalization and tumorigenesis |
| Secretariat |
Genetic and environmental modifiers of cancer predisposition in mismatch-repair-deficient mice |
| Secretariat |
Characterization of antigen specificities and biological responses of CD4+ melanoma specific T cells. |
| Secretariat |
Mechanisms of reduced cellular accumulation of topoisomerase I inhibitors |
| Secretariat |
Transport of taxoids across the blood-brain barrier and CNS tumor penetration: a preclinical pharmacological study and clinical 'proof of concept' testing in glioma patients. |
| Secretariat |
Quantitative assessment of treatment margins and implementation of multimodality imaging in breast-conserving therapy. |
| Secretariat |
Mechanism of cell cycle regulation and control of cellular lifespan by the Polycomb-group and oncogene Bmi1. |
| Secretariat |
Structure-function studies of cyclin D1 in complex with nuclear hormone receptors and/or coactivators. |
| Secretariat |
The role of the nuclear inositide pathway in cell cycle progression. |
| Secretariat |
The role of interleukin 10 in immunosuppression of tumor responses. |
| Secretariat |
Modulation of normal human T cell development by ectopic expression of TAL-1,-2 and and LYL in T cell prognitor cells |
| Secretariat |
Induction of apoptosis by alkyl-lysophospholipids and related antitumor agents. |
| Secretariat |
G protein control of cell proliferation and transformation. |
| Secretariat |
The role of the integrin alpha6-beta4 in signal transduction controlling cell proliferation. |
| Secretariat |
Dephosphorylation of retinoblastoma family proteins by protein phosphatase 2A |
| Secretariat |
Development of a mouse model to study the genetic basis of malignant mesothelioma. |
