KNAW

Organisation

Leiden Institute of Chemistry

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Completed research

(the most recent research is at the top)
Collaboration Efficient development of small molecule inhibitorsof tyrosine kinases - Identification of EphA4 blockers as anti-cancer lead compounds
Collaboration Imagining Genomics: Introducing visuality in the genomics debate
Collaboration Fundamentals of a new class of oxidation processes based on thermal and photo-catalysis in basic zeolites (TPC.6057
Collaboration Nickel N-heterocyclic carbene complexes in homogeneous catalysis
Collaboration B-Basic: Bio-based Sustainable Industrial Chemistry
Collaboration Structural enzyme kinetics: studies on Chlorella DNA ligase
Collaboration On the stability of molecules and microorganisms in planetary and interstellar environments
Collaboration Characterization of Thin Film Photoanodes for Solar Water Splitting
Collaboration Numerical algorithms in bio-informatics
Collaboration Design, synthesis and application of molecularly defined TLR ligand-antigen conjugates for optimal DC activation and specific T cell induction.
Collaboration ECOX Project - Oxidation catalysis for sustainability inside the chemical and detergent industry
Collaboration Molecular order in and around "lipid rafts"
Collaboration Organic chemistry on Mars
Collaboration Development of a novel class of catalysts using the combinatorial chemistry approach
Secretariat Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Secretariat Interfacing Functional Nanocomposites for Non-Volatile Memory Devices
Secretariat Development of advanced drug discovery methods
Secretariat Imaging of dynamic events with cryo-EM: digital, time-resolved quantum imaging of viruses and other macromolecular complexes
Secretariat GENomics and EXpression of Peptide ANtibiotics and Derivatives (GENEXPAND)
Secretariat Theoretical characterization and optimization of transition metal synthetic catalysts for water oxidation
Secretariat Structure-based insights into the repair of UV-damaged DNA
Secretariat Outsmarting Influenza and Chagas Disease: Developing Mechanism-based Sialidase Inhibitors for Study and Treatment
Secretariat Energy-Transfer Phenomena in Solution and at Surfaces
Secretariat Potential-dependent ab initio calculations of dissociative water adsorption on stepped platinum surfaces
Secretariat Novel mechanisms in bacterial cell division: an integrated approach to unravel the septum localising complex of streptomycetes
Secretariat Step Away From Flat Land; employing a Cylindrical Crystal in Gas-Surface Dynamics Studies
Secretariat Formation mechanisms of key astrochemical ice components
Secretariat In vivo µMRI and MRS studies in assessment of early biomarkers of AD
Secretariat Deployment of the Leiden Grid Infrastructure
Secretariat Developing a chloride-free route to epoxy resins
Secretariat Facility for on-line product detection in selective electrocatalysis
Secretariat Dimeric ligands for GPCRs involved in human reproduction: synthesis and biological evaluation
Secretariat Mechanisms of hydrogen storage in alanates; a first principles approach
Secretariat Programmed DNA directed molecular self-assembly of redox proteins in biosensor design
Secretariat New approaches for accurate and efficient macromolecular crystal structure solutions
Secretariat New directors in the cell division orchestra: coordinating multiple septation and chromosome segregation in filamentous streptomycetes
Secretariat Nucleotide Excision Repair in Yeast
Secretariat Damage recognition in nucleotide excision repair
Secretariat Peptide-polymer hybrid coatings with antibiotic activity
Secretariat A protein-based artificial solar antenna derived from biological self-organization principles
Secretariat Hydrogen storage in nanoporous clathrate materials
Secretariat The palladium diphosphane catalyzed reduction of nitrobenzene
Secretariat Art & Genomics
Secretariat Parallellisation SURFSCAT
Secretariat Spin torch experiments observed in reaction centers of Rhodobacter sphaeroides
Secretariat Ab initio modeling of primary processes in photosynthesis: Protein induced activation of bacteriochlorophylls for efficient light harvesting and charge separation
Secretariat Photo-CIDNP MAS NMR on isotope-labeled photosynthetic reaction centers
Secretariat Chemical activity of anticancer compounds: computational studies on the mechanism of bleomycin and the recognition of flavonoids
Secretariat In vivo high field magnetic resonance imaging and spectroscopy of adult zebrafish
Secretariat Photo-CIDNP MAS NMR on oriented photosynthetic reaction centers
Secretariat Magnetic resonance imaging and spectroscopy of Alzheimer's disease in transgenic mice in vivo
Secretariat Biological photoreceptors
Secretariat Molecular Structure and Function of Proline Rich Proteins
Secretariat Magnetic Resonance Microimaging on the Zebrafish
Secretariat Magnetic Resonance Imaging (MRI) of Alzheimer’s Disease (AD)
Secretariat Electronic Structure of Coordinating Histidines in Photosynthetic Complexes
Secretariat Antioxidant properties of small proline-rich proteins
Secretariat Influence of the DDB1/2 complex on DNA damage signaling in murine keratinocytes
Secretariat Interplay between DNA damage responses in UV-exposed murine skin
Secretariat MelC1 of Streptomyces antibioticus, an accessory protein of tyrosinase involved in secretion and copper incorporation.
Secretariat The relation between copper homeostasis and morphological differentiation in Streptomyces
Secretariat In search for anticancer transition-metal compounds with dual DNA-binding and cleaving properties
Secretariat The design and synthesis of novel heterodinuclear complexes combining a DNA cleaving agent and a DNA targeting moiety
Secretariat Synthesis, Characterization and Biological Studies of Ruthenium and Gold Compounds with Anticancer Properties
Secretariat Ruthenium polypyridyl complexes with anticancer properties
Secretariat Phenol-pyrazole based ligands towards the design of manganese complexes
Secretariat New d-f multifunctional molecular materials
Secretariat Catalytic allylation of phenols: chloride-free route towards epoxy resins
Secretariat Crystal Engineering: A Matter of Rational Ligand design
Secretariat Homogeneous bio-inspired copper-catalyzed oxidation reactions
Secretariat Structural and functional models for [NiFe] hydrogenase
Secretariat Towards peptide based therapeutics-Applications in celiac disease and infectious diseases
Secretariat A search for a facile synthesis route towards immunological important sugar building blocks
Secretariat Protein nanocrystallisation
Secretariat Method development for Cryo-electron microscopy
Secretariat Profiling of Soluble and Membrane-Bound Metalloproteases: A Targeted Proteomics Approach
Secretariat Synthetic Methodology for the Preparation of Nucleic Acid Containing Peptides
Secretariat Manganese-enhanced MRI of migraine mice:in vivo evaluation of calcium channel functioning
Secretariat Novel Methods for Fragment-based Drug Discovery
Secretariat Hybrid quantum mechanics-molecular mechanics study of the bleomycin acitvity
Secretariat Cyttron: A window on the molecular machinery of life
Secretariat Dynamics and structural features of the microtubule plus-ends in interphase mouse fibroblasts
Secretariat Molecular approach
Secretariat From 3D structure to cell biology: new roles for replication factor C
Secretariat Whole cell catalysed conversion innovated by peptaibol mediated transport of polar compounds across the bacterial cell membrane
Secretariat Search for regulatory elements of the streptomycin operon of E. coli by means of DNA/RNA combinatorial chemistry methods
Secretariat Nanosized Au clusters as novel catalysts for low-temperature CO oxidation and selective oxidation of light hydrocarbons
Secretariat Experimental and theoretical studies of non-linear phenomena in catalytic oxidation of NH3 and reduction of N2O over platinum metal surfaces: intermediates, phase transitions, oscillations, mathematical modelling
Secretariat Bifunctional metal complex binding to DNA: medicinal aspects
Secretariat Self-replicating polymersomes
Secretariat Translational control by a molecular Trojan horse
Secretariat RNA pseudo-triloops: key structures in RNA-protein recognition and targets for potential drugs
Secretariat Quantum dynamics of chemical reactions
Secretariat Structural and biochemical characterization of the BRTC domains and their ligand interactions of the human breast cancer susceptibility gene 1 (BRCA1) protein
Secretariat Coordination chemistry of manganese and iron with N,O-donor ligands: oxidation catalysis and magnetochemistry of clusters
Secretariat Ultrafast studies of chemical reactions at surfaces
Secretariat Native chemical glycosylation - A novel and efficient method for the synthesis of complex glycoconjugates
Secretariat Reconstruction of the ribosome
Secretariat Computational chemistry for biological systems
Secretariat Crank-automated crystallographic structure solution
Secretariat Oxacarbenium ion intermediates in the stereoselective synthesis of anionic oligosaccharides
Secretariat Single-enzyme electrochemistry at nanoelectrodes
Secretariat The solid-state photo-cidnp effect
Secretariat Pushing the mesoscopic frontier
Secretariat Parallelization and optimization of wave packet code for moleculesurface scattering for use on Teras, Aster, Solo and Lisa
Secretariat Bridging the gap between natural & artificial light-harvesting
Secretariat Electronic and spatial characteristics of the retinylidene chromophore of rhodopsin
Secretariat Multiplex sum-frequence generation (SFG) microspectroscopy
Secretariat Structural biology of induced conformational changes
Secretariat Electron transfer correlated protein dynamics
Secretariat Photo-CIDNP solid-state MR on oriented photosynthetic membranes revealing the spatial and electronic structure of the primary electron donors
Secretariat Catalytic behaviour of Cu, Ag and Au nanoparticles
Secretariat Production and storage of hydrogen; a first principles approach
Secretariat Transient interactions between photosynthetic proteins
Secretariat EPR and NMR Spectroscopy on Spin Labeled Proteins
Secretariat Synthesis studies of the zwitterionic polysaccharide PS A1, a major cause of human abdominal abscesses
Secretariat Transient complexes of haem proteins
Secretariat Revealing the electronic structure of P680 by photo-CIDNP solid-state NMR
Secretariat The application of multivariate probabilistic methods to X-ray crystallographic phasing and model refinement
Secretariat Organic Chemistry in Living Cells: Profiling of Functional Biomolecules
Secretariat Three-dimensional molecules
Secretariat Control of microbial morphology: novel regulators of cell division
Secretariat Femtosecond dynamics of surface chemistry
Secretariat Crystallographic structure determination of receptor-ligand complexes involved in adenovirus infection and T-cell stimulation

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