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Person

Prof.dr. J.L. Bos

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Expertise	Molecular biology; Signal transduction; Molecular mechanisms of carcinogenesis
Expertise (NL)	Moleculaire biologie; Signaal transductie; Moleculaire mechanismen van het ontstaan van kanker
Digital Author ID	info:eu-repo/dai/nl/304813664
KNAW member	Science Division

Active as

Professor
Organisation	Department of Molecular Cancer Research (UU)
Chair (EN)	Molecular biology
Chair (NL)	Moleculaire biologie
Phone	+31-88-7568977
Email	J. L. Bos -at- umcutrecht. nl
URL	http://groups.mcr.umcutrecht.nl/bos/

Management
Organisation	Cancer Genomics & Developmental Biology - The PhD programme (UU)
Email	J. L. Bos -at- umcutrecht. nl
URL	http://ruummc.med.uu.nl/

Publications

Specificity in Ras and Rap signaling
cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics

Current research

(the most recent research is at the top)
Project leader	Spatial and temporal regulation and function of Epac1
Project leader	Cancer Genomics and Developmental Biology
Researcher	Protein interactions at multiple scales
Project leader	The role of the small GTPase Ral in the control of FOXO transcription factors and cell transformation.
Project leader	Cancer proteomics

All current research..

Completed research projects

(the most recent research is at the top)
Project leader	Function and regulation of the Ras-like GTPase Rheb in tuberous sclerosis
Project leader	Epac: a novel cAMP
Project leader	cAMP-mediated regulation of cell proliferation by protein kinase A-independent pathways
Project leader	Intermediates in the signalling pathway from Ras-Ral to transcription factors
Project leader	Signal transduction by small GTPases of the Ras family

All completed research..

Classification

D21300	Biochemistry
D21700	Physiology

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