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Prof.dr. J.L. Bos

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Expertise	Molecular biology; Signal transduction; Molecular mechanisms of carcinogenesis
Expertise (NL)	Moleculaire biologie; Signaal transductie; Moleculaire mechanismen van het ontstaan van kanker
Digital Author ID	info:eu-repo/dai/nl/067853323
KNAW member	Science Division

Active as

Professor
Organisation	Department of Molecular Cancer Research (UU)
Chair (EN)	Molecular biology
Chair (NL)	Moleculaire biologie
Phone	+31-88-7568977
Email	J. L. Bos -at- umcutrecht. nl
URL	http://groups.mcr.umcutrecht.nl/bos/

Management
Organisation	Centre for Biomedical Genetics (CBG) (CBG)
Email	J. L. Bos -at- umcutrecht. nl

Publications

(the most recent at the top)
Structural dynamics in the activation of Epac
The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner
Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP
Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

All publications..

Current research

(the most recent research is at the top)
Project leader	Personalized Cancer Care
Project leader	Spatial and temporal regulation and function of Epac1
Project leader	Cancer Genomics and Developmental Biology
Researcher	Functional screens

Completed research projects

(the most recent research is at the top)
Researcher	Protein interactions at multiple scales
Project leader	The role of the small GTPase Ral in the control of FOXO transcription factors and cell transformation.
Project leader	Cancer proteomics
Project leader	Function and regulation of the Ras-like GTPase Rheb in tuberous sclerosis
Project leader	Epac: a novel cAMP

All completed research..

Classification

D21300	Biochemistry
D21700	Physiology

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