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Person

Prof.dr. J.C. Clevers

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Expertise	Molecular biology; Transcription regulation; Oncogenetics; Genetics
Expertise (NL)	Moleculaire biologie; Transcriptieregulatie; Oncogenetica; Genetica
Digital Author ID	info:eu-repo/dai/nl/07164282X
KNAW member	Science Division
Addition	Buitengewoon hoogleraar Moleculaire genetica aan het Universitair Medisch Centrum Utrecht en aan de Faculteit Diergeneeskunde, Universiteit Utrecht \|Rabbi Shai Shacknai Memorial Prijs 2006
Grants/prizes	NWO - Spinozapremie 2001

Active as

Professor
Organisation	Department of Molecular Cancer Research (UU)
Chair (EN)	Molecular Genetics
Chair (NL)	Moleculaire Genetica
Phone	+31-30-2121831
Email	h. clevers -at- hubrecht. eu
URL	http://www.hubrecht.eu/research/clevers/

Management
Organisation	Hubrecht Institute (KNAW)
Email	h. clevers -at- hubrecht. eu
URL	http://www.hubrecht.eu/research/clevers/

Programm leader / Group leader
Organisation	Hubrecht Institute (KNAW)
Email	h. clevers -at- hubrecht. eu
URL	http://www.hubrecht.eu/research/clevers/

Publications

Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition
Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss
Coexistence of quiescent and active adult stem cells in mammals
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice

All publications..

Enhanced publications

Doctoral Thesis: Bmp signaling is at the heart of vertebrate left-right symmetry

Current research

(the most recent research is at the top)
Project leader	Wnt signaling and cancer
Project leader	Notch signaling in stem cell renewal and cancer of the intestine
Project leader	The TCF4 target gene program and the mesenchymal niche in intestinal crypts and colon cancer
Project leader	Unraveling CYLD (dys)function in the development of skin appendage tumors
Researcher	Cancer proteomics

All current research..

Completed research projects

(the most recent research is at the top)
Project leader	TCF factors, mediators of Wnt signaling in development and cancer
Supervisor	Bmp signaling is at the heart of vertebrate left-right asymmetry
Supervisor	The expression and function of microRNAs in vertebrate embryonic development
Project leader	The Peutz-Jeghers tumour suppressor kinase LKB1 is a master regulator of polarity
Project leader	Molecular manoeuvres in the Wnt cascade

All completed research..

Classification

C10000	Biotechnology
D21400	Genetics
D21800	Immunology, serology
D23120	Oncology

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