Prof.dr.ir. I.M.C.M. Rietjens

Update Persondata

• antioxidants
• biochemical
• biotransformation
• computer
• enzymes
• enzymology
• modeling
• molecular
• redox
• toxicology
• xenobiotics

Active as

Publications

(the most recent at the top)

Surface charge-specific cytotoxicity and cellular uptake of tri-block copolymer nanoparticles

Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

Cytotoxicity of surface-functionalized silicon and germanium nanoparticles: the dominant role of surface charges

Characterisation of exposure and effects of silver nanoparticles to the earthworm Lumbricus rubellus

Interference of flavonoids with enzymatic assays for the determination of free fatty acid and triglyceride levels

All publications..

Enhanced publications

(the most recent at the top)

Doctoral Thesis: Unravelling the mechanism of differential biological responses induced by food-borne xeno- and phyto-estrogenic compounds

Doctoral Thesis: The potential of computer-based quantitative structure activity approaches for predicting acute toxicity of chemicals

Doctoral Thesis: The analysis of lipophilic marine toxins : development of an alternative method

Doctoral Thesis: Increasing hesperetin bioavailability by modulating intestinal metabolism and transport

Current research

(the most recent research is at the top)
Supervisor	Toxicity assays for prioritization and risk assessment of nanoparticles
Supervisor	Mode of action-based new bioassays of marine biotoxins
Supervisor	The transfer of chemical residues into eggs.
Supervisor	Quantification and Characterization of External and Internal Exposure of soil organisms to Nanoparticles and related Toxicity
Supervisor	Physiologically based kinetic (PBK) of the oral systematic availability of quercetin and its metabolites in rats and humans

All current research..

Completed research projects

(the most recent research is at the top)
Supervisor	Development of aquatic biomonitoring models for surface waters used for drinking water supply specific attention for genotoxicity
Supervisor	Development of improved and new in vitro assays for detecting genotoxic and non-genotoxic carcinogenic potential of chemicals in the discovery phase of drug development.
Supervisor	Risk-benefit analysis of flavonoids
Supervisor	Biochemoprevention of colorectal neoplasia:interactions between planfoods and polymorphisms in coding as well as regulatory DNA sequences - 2
Supervisor	Zebrafish as an alternative model for (developmental) toxicitytesting.

All completed research..

Classification

A34600	Foods and stimulants
A70000	Public health and health care
C10000	Biotechnology
D21300	Biochemistry
D23340	Biopharmacology, toxicology