Dr. D.C. van Gent

Update Persondata

• biochemistry
• homologous
• integration
• interactions
• joining
• protein
• recombination
• repair
• retroviral
• transposition

Active as

Publications

(the most recent at the top)

The DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress response

A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen

A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation

Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining

Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends

All publications..

Current research

(the most recent research is at the top)
Project leader	Dynamic Interactions of Non-Homologous End-Joining Proteins with DNA breaks

Completed research projects

(the most recent research is at the top)
Project leader	Identificaton of DNA double-strand break repair genes that are important for maintaining chromosomal stability and ionizing radiation resistance
Project leader	The role of the RAG proteins in chromosomal translocations and the development of lymphoid malignancies
Researcher	Repair of double strand breaks and cross-links in DNA
Project leader	Genetics and biochemistry of DNA double-strand break in mammals.

Classification

A70000	Public health and health care
C10000	Biotechnology
D21300	Biochemistry
D21400	Genetics
D21500	Histology, cell biology
D23120	Oncology