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Person

Prof.dr. J.H.M. Schellens

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Digital Author ID	info:eu-repo/dai/nl/073926272
Addition	Oncoloog/klinisch farmacoloog Nederlands Kanker Instituut/Antoni van Leeuwenhoek Ziekenhuis, Amsterdam

Active as

Programm leader / Group leader
Organisation	The Netherlands Cancer Institute
Email	j. schellens -at- nki. nl
URL	http://www.nki.nl/ShowObject.asp?NodeID=2525

Professor
Organisation	Department of Pharmaco-epidemiology and Clinical Pharmacology (UU)
Chair (EN)	Clinical medicine toxicology
Chair (NL)	Klinische geneesmiddelentoxicologie
Phone	+31-30-2537324
Email	j. schellens -at- nki. nl

Publications

Specific Investigation of Sample Handling Effects on Protease Activities and Absolute Serum Concentrations of Various Putative Peptidome Cancer Biomarkers

Current research

(the most recent research is at the top)
Project leader	Prediction of pharmacokinetic interactions between complementary, alternative medicines and (new) anticancer drugs
Project leader	Preclinical validation of chemical inhibitors of poly(ADP-ribose) polymerase (PARP) in conditional mouse models for BRCA-associated breast cancer
Project leader	Biomedical Analysis : Functional and structural characterization

Completed research projects

(the most recent research is at the top)
Project leader	Preclinical and clinical pharmacology of oral drugs
Project leader	Prevention and therapy of tumors
Project leader	mTHPC-mediated photodynamic therapy (PDT): how do drug uptake and distribution influence tumour and normal tissue response?
Project leader	Modulation of cytochrome P450 (CYP) and P-glycoprotein (P-gp) and BCR activity in gut wall and liver as major determinants of poor oral bioavailability of anticancer drugs: preclinical and clinical studies
Project leader	The use of novel pharmacodynamic end-points in early clinical trials: focus on farnesyltransferase inhibitors

All completed research..

Classification

A34800	Drugs and pesticides
D23340	Biopharmacology, toxicology

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