KNAW

Back to search results
Person

Dr. A.H. Schinkel

Pagina-navigatie:


Update Persondata


Expertise P-glycoprotein; Multidrug resistance; Drug transporters; Pharmacokinetics; Knockout mice; Drug metabolism
Expertise (NL) P-glycoproteine; Multidrug resistentie; Drug transporters; Farmacokinetiek; Knockout muizen; Drug metabolisme

Active as

Researcher
Organisation The Netherlands Cancer Institute
Phone +31-20-5122046
Email alfred -at- nki. nl

Current research

(the most recent research is at the top)
Project leader OATP1A/1B (SLCO1A/1B) drug uptake transporters in anticancer drug pharmacokinetics and toxicity risks; possible strategies for therapy optimization

Completed research projects

(the most recent research is at the top)
Project leader Impact of the multidrug transporters p-glycoprot., MRP2 and BCRP on the behaviour of anti-cancer drugs
Project leader Generation and validation of cytochrome P450 3A knockout and transgenic mice as tools for improved drug development and research
Project leader Modulation of cytochrome P450 (CYP) and P-glycoprotein (P-gp) and BCR activity in gut wall and liver as major determinants of poor oral bioavailability of anticancer drugs: preclinical and clinical studies
Project leader Compound Mrp2 (Abcc2) and other drug transporter knockout mice to study determinants of pharmacokinetics, toxicity risks and possible therapy optimization for anticancer drugs
Project leader Physiological and pharmacological analysis of the novel multidrug resistance gene Bcrp (breast cancer resistance protein) using Brcp knockout mice
All completed research..

Classification

A34800 Drugs and pesticides
A70000 Public health and health care
C10000 Biotechnology
D21300 Biochemistry
D21400 Genetics
D23120 Oncology
D23340 Biopharmacology, toxicology

Go to page top
Go back to contents
Go back to site navigation