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Prof.dr. H.Th.M. Timmers

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Expertise Gene regulation; Molecular biology; Biochemistry; In vitro transcription; Protein expression (recombinant); Protein purification; RNA polymerase II transcription; Transcription factors; Chromatine; histone methylation
Expertise (NL) Genregulatie in het algemeen; Moleculaire biologie; Biochemie; In vitro transcriptie; Eiwit expressie (recombinant); Eiwit zuivering; RNA polymerase II transcriptie; Transcriptie factoren; Chromatine; histonmethylering
Digital Author ID info:eu-repo/dai/nl/074858432
Addition Afgevaardigde KNCV-ledenraad; Lid redactieraad CZW; Member of the Editorial Board of the Journal of Biological Chemistry; Theme leader of Netherlands Proteomics Centre

Active as

Professor
Organisation Department of Molecular Cancer Research (UU)
Chair (EN) Molecular Biology
Chair (NL) Moleculaire Biologie
Phone +31-88-7568537
Email h. t. m. timmers -at- umcutrecht. nl

Publications

E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system
Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3
Dynamics and metal exchange properties of C4C4 RING domains from CNOT4 and the p44 subunit of TFIIH .
Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex
All publications..

Enhanced publications

Doctoral Thesis: Nuclear Receptors and Multiple Endocrine Neoplasia type 1 (MEN1)
Doctoral Thesis: Genome-wide regulation of TATA-binding protein activity

Current research

(the most recent research is at the top)
Project leader Revealing CROSS-talk between epigenetic regulatory pathways
Project leader Linking the genomic dynamics of transcription complexes with mRNA output
Project leader Histone methylation and transcription: Writing and Reading of the code

Completed research projects

(the most recent research is at the top)
Project leader Nuclear action of mRNAs
Supervisor Genome-wide regulation of TATA-binding protein activity
Supervisor Nuclear Receptors and Multiple Endocrine Neoplasia type 1 (MEN1)
Project leader Regulation of transcription by RNA polymerase II

Classification

A70000 Public health and health care
D21300 Biochemistry
D21400 Genetics

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