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Prof.dr. G.J.L. Kaspers

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Update Persondata


Expertise Cellular drug resistance; MTT assay; DiSC assay; multidrug resistance; Apoptosis; Caspases; BCL-2 family members; Cell death regulators; Glucocorticoids; Prednisolone; Dexamethasone; Methotrexate; Antifolates; Cytarabine; Cladribine; Fludarabine; Nucleoside analogues; CMA-676 (Mylotarg); Leukemia; Retinoblastoma; Brain tumors; Relapsed and refractory acute myeloid leukemia
Expertise (NL) Cellulaire cytostatica-resistentie; MTT test; DISC test; Multi-drug resistentie; Apoptose; Glucocorticoiden: Prednisolon; Dexamethason; Methotrexaat; Antifolaten; Cytarabine; Cladribine; Fludarabine; Nucleoside analoga; CMA-676 (mylotarg); Leukemie; Retinoblastoom; Hersentumoren; Recidief en refractaire acute myeloide leukemie; Caspases; Celdoodregulatoren; Bcl-2 familieleden
Addition Member Dutch Society of Oncology, Dutch Pediatric Association, Royal Dutch Society of Medicine, American Society of Hematology, American Association of Cancer research, European Haematology Association, International Society of Pediatric Oncology; Member Dutch Childhood Leukemia Study Group committees on acute Lymphoblastic Leukemia-10"and "Relapsed Acute Myeloid Leukemia-1999"; Chairman of the "AML Committee"of the International BFM Study Group; Member of the "Committee of Scientific Research"

Active as

Professor
Organisation Department of Pediatrics (VU)
Chair (EN) Pediatric oncology
Chair (NL) Kindergeneeskunde i.h.b. de hemato-oncologie
Phone +31-20-4442420
Email gjl. kaspers -at- vumc. nl

Current research

(the most recent research is at the top)
Project leader Application of bortezomib in pediatric acute lymphoblastic leukemiaChildhood relapsed ALL remains a significant problem in pediatric oncology, therefore novel drugs with a new mechanism of action are needed to improve prognosis. The proteasome inhibitor bortezomib (PS341, Velcade®, BTZ) represents a
Project leader Glucocorticoid induced HPA axis suppression in childhood acute lymphoblastic leukemia and lymphoma

Completed research projects

(the most recent research is at the top)
Project leader ALL treatment in acute lymphoblastic leukemia in children: a study into adjustment, quality of life, and costs
Project leader Cell biological characteristics, drug resistance and clinical studies in pediatric oncology
Supervisor Experimental treatment modalities for osteosarcoma. Preclinical studies on virotherapy, chemotherapy and small molecule therapy
Project leader Receptor tyrosine kinases as new targets in the treatment of childhood acute myeloid leukaemia
Researcher Characterization of relapsed acute myeloid leukemia
All completed research..

Classification

A70000 Public health and health care
D21800 Immunology, serology
D23120 Oncology
D23221 Blood and lymphatic diseases
D23362 Pediatrics

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