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Prof.dr. I. Joosten

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Expertise Transplantation immunology; MHC; HLA typing; T cell activation; Costimulation blocking; MHC-peptide binding; Regulatory T cells; Reproductive immunology; Natural killer cells; HLA-G
Expertise (NL) Transplantatie-immunologie; MHC; HLA typering; T cel aktivering; Costimulering blokkade; MHC-peptide binding; Regulerende T cellen; Voortplantingsimmunologie; Natural killer cellen; HLA-G
Digital Author ID info:eu-repo/dai/nl/075051877
Addition Wetenschappelijk medewerker|Lid HLA werkgroep Nederland; Lid Coördinatiecommissie Europdonor Nijmegen; Secretaris Werkgroep medische immunologie UMC StRadboud

Active as

Professor
Organisation Department Laboratory Medicine (RU)
Chair (EN) Medical Immunology, in particular Transplantation and Transfusion Immunology
Chair (NL) Medische Immunologie, in het bijzonder de Transplantatie- en Transfusie Immunologie
Phone +31-24-3615335
Email I. Joosten -at- abti. umcn. nl

Publications

De kracht van het verschil
Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation.
DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells.
CD3+/CD19+-depleted grafts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A.
High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy.
All publications..

Enhanced publications

Doctoral Thesis: Allo-specific immunosuppression by relatory T cells

Current research

(the most recent research is at the top)
Project leader The effects of rituximab on the composition of the peripheral T cell population in renal transplant patients

Completed research projects

(the most recent research is at the top)
Project leader Selection and functional characterization of alloantigen-specific regulatory T cell subsets for clinical use in organ transplantation
Co-supervisor Facilitation of CD4+ CD 25+ Regulatory T-Cell function in transplantation
Co-supervisor Induction of donor-specific T cell tolerance in transplantation
Project leader Ex vivo induction of regulatory donor-specific T cells in transplantation

Classification

A70000 Public health and health care
D21800 Immunology, serology

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