Prof.dr. R.H. Medema

Update Persondata

• apoptosis
• cell
• checkpoints
• cycle
• cyclins
• damage
• hemato
• inhibiotors
• mitosis
• oncogenesis
• regulation

Active as

Publications

(the most recent at the top)

Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody

Exploiting the compromised spindle assembly checkpoint function of tumor cells: dawn on the horizon?

CLIP-170 facilitates the formation of kinetochore-microtubule attachments

Uncoupling the Central Spindle-associated Function of the Chromosomal Passenger Complex from Its Role at Centromeres

FoxM1 is required for execution of the mitotic programme and chromosome stability

All publications..

Enhanced publications

(the most recent at the top)

Doctoral Thesis: Molecular control of bipolar spindle assembly

Current research

(the most recent research is at the top)
Project leader	Motor proteins in spindle assembly: targets for cancer therapy?
Project leader	A phosphoproteomic approach to uncover regulators of checkpoint recovery
Supervisor	The role of tumor-initiating cells in cancer metastasis and drug resistance

Completed research projects

(the most recent research is at the top)
Supervisor	Molecular control of bipolar spindle assembly
Project leader	Contribution of FoxM1 to tumorigenesis
Project leader	Signal Transduction by the Mitotic Checkpoint Kinase BubR1
Project leader	Checkpoint recovery and adaptation following genotoxic therapies
Project leader	Biosynthesis and function of base J, a new base in the nuclear DNA of kinetoplastid parasites

All completed research..

Classification

A70000	Public health and health care
D21400	Genetics
D21500	Histology, cell biology
D23120	Oncology