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Prof.dr. T.K. Sixma Person

Prof.dr. T.K. Sixma

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Expertise Protein crystallography
Expertise (NL) Eiwit structuur-functie relaties door middel van röntgendiffraktie
KNAW member Science Division
Addition Bijzonder hoogleraar vanwege Het Nederlands Kanker Instituut; Stafmedewerker; Lid bestuur Nederlandse Vereniging voor Kristallografie; Lid KNAW commissie voor Biochemie en Biofysica

Active as

Programm leader / Group leader
Organisation The Netherlands Cancer Institute
Phone +31-20-5121959
Email t. sixma -at- nki. nl
URL http://xtal.nki.nl/Titia_group/
Extraordinary professor
Organisation Department of Genetics (EUR)
Chair (EN) Protein structure and function
Chair (NL) Structuur en functie van eiwitten
Email t. sixma -at- nki. nl
Management
Organisation Oncology Graduate School Amsterdam (VU)
Email t. sixma -at- nki. nl

Current research

(the most recent research is at the top)
Project leader The regulatory role of Ubl domains in ubiquitin specific protease function
Project leader Initiation of DNA mismatch repair
Project leader Comparative study of Ubiqutin-specific proteases
Project leader Structural and functional analysis of a novel E3 ubiquitin ligase consisting of the polycomb proteins Bmi1 and Ring1b (RNF2)
Project leader Biosynthesis and function of base J, a new base in the nuclear DNA of kinetoplastid parasites

Completed research projects

(the most recent research is at the top)
Project leader Exploring new uses of AChBP as model for ligand-gated ion channel research
Project leader L1 and Alu elements: structural and functional analysis of human non-LTR retrotransposons
Project leader Subtle gene modification to study the role of the mismatch repair complex MSH2/MSH6 in mutation avoidance and tumor suppression
Project leader Purchase of X-ray diffraction equipment (X-ray mirrors, image plate, nitrogen cryo-stream)
Supervisor Structural and functional analysis of the human L1/Alu retroposition machinery
All completed research..

Classification

A70000 Public health and health care
D12300 Electromagnetism, optics, acoustics
D13500 Physical chemistry
D23120 Oncology

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