Prof.dr. J.A.M. Smeitink

Update Persondata

• biochemistry
• diseases
• errors
• genetics
• inborn
• medicine
• metabolism
• mitochondrial
• paediatrics

Active as

Publications

(the most recent at the top)

Impaired ubiquitin-proteasome-mediated PGC-1alpha protein turnover and induced mitochondrial biogenesis secondary to complex-I deficiency.

Metabolic consequences of NDUFS4 gene deletion in immortalized mouse embryonic fibroblasts.

Mitochondrial ATP synthase: architecture, function and pathology.

Mitochondrial DNA m.3242G > A mutation, an under diagnosed cause of hypertrophic cardiomyopathy and renal tubular dysfunction?

Mitochondrial complex III stabilizes complex I in the absence of NDUFS4 to provide partial activity.

All publications..

Enhanced publications

(the most recent at the top)

Doctoral Thesis: The assembly of mitochondrial Complex I : A product of nuclear-mitochondrial synergy

Current research

(the most recent research is at the top)
Project leader	Nutraceuticals as potential modulators of Mitochondrial Energy Metabolism: a Translational Study
Project leader	Modelling therapeutic interventions in mitochondrial bioenergetics

Completed research projects

(the most recent research is at the top)
Project leader	New tools for the identification of nutritional modulators of mitochondrial activity: small molecules that promote health and combat disease
Supervisor	The assembly of Mitochondrial Complex I: A product of nuclear-mitochondrial synergy
Project leader	Identification of non-structural complex I genes which are responsible for isolated mitochondrial complex I deficiency

Classification

D21400	Genetics
D21700	Physiology
D23362	Pediatrics