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Prof.dr. H.P.J. te Riele

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Update Persondata


Expertise Generation and study of mouse models for hereditary cancer; Genetic modification in mouse embryonic stem cells; Homologous recombination; DNA mismatch repair; Tumor suppressor genes; Cell cycle
Expertise (NL) Genereren en bestuderen van muismodellen voor erfelijke vormen van kanker; Genetische modificatie in embryonale stamcellen; Homologe recombinatie; DNA mismatch repair; Tumorsuppressor genen; Celcyclus
Addition Bijzonder hoogleraar vanwege het Nederlands Kanker Instituut Antoni van Leeuwenhoek Ziekenhuis (NKI/AvL); Bestuurslid Nederlandse Genetische Vereniging

Active as

Extraordinary professor
Organisation Department of Clinical Genetics and Anthropogenetics (VU)
Chair (EN) Genetic instability and carcinogenesis
Chair (NL) Genetische instabiliteit en carcinognese
Phone +31-20-5122084
Email h. t. riele -at- nki. nl
Researcher
Organisation The Netherlands Cancer Institute
Phone +31-20-5122084
Email h. t. riele -at- nki. nl

Current research

(the most recent research is at the top)
Project leader Modifiers of tumor development in Lynch syndrome
Project leader Role of the G2 restriction point in tumor development and behaviour

Completed research projects

(the most recent research is at the top)
Project leader Mitotic entry and exit: the rise and fall of cyclin-Cdk-Cks activity
Supervisor FANCM, the mouse that roared
Supervisor Gene targeting by single-stranded DNA oligonucleotides in mouse embryonic stem cells
Project leader Subtle gene modification to study the role of the mismatch repair complex MSH2/MSH6 in mutation avoidance and tumor suppression
Project leader The identification of oncogenic events collaborating with loss of function of the retinoblastoma gene family in tumor development and progression
All completed research..

Classification

D21400 Genetics
D23120 Oncology

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