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Prof.dr. E.M. Hol Person

Prof.dr. E.M. Hol

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Expertise Neural stem cells; glia; Ubiquitin proteasome system; GFAP; astrocytes; adult neurogenesis; neurodegenerative diseases; Alzheimer; Parkinson
Expertise (NL) Neurale stamcellen; glia; Ubiquitine proteasoom systeem; GFAP; astrocyten; Neurodegeneratieve ziekten; Alzheimer; Parkinson
Digital Author ID info:eu-repo/dai/nl/126317097
Addition Bijzonder hoogleraar vanwege het NIN-KNAW
Grants/prizes NWO-Vici 2008

Active as

Programm leader / Group leader
Organisation Netherlands Institute for Neuroscience NIN (KNAW)
Chair (EN) Biology of Glia and Neural Stem cells
Chair (NL) Biolgie van Glia en Neurale Stamcellen
Phone +31-20-5665498
Email e. hol -at- nin. knaw. nl
URL http://www.nin.knaw.nl/research_groups/hol_group/
Extraordinary professor
Organisation Swammerdam Institute for Life Sciences - SILS (UvA)
Chair (EN) Biology of Glial and Neural Stem Cells
Chair (NL) Biologie van glia en neurale stamcellen
Email E. M. Hol -at- uva. nl
URL http://www.nin.knaw.nl/research_groups/hol_group/

Publications

The endogenous repair capacity of the parkinsonian brain
Astrocytes in development, aging and disease: starring GFAP
Dynamics of ataxin-1 in spinocerebellar ataxia type 1
GFAPdelta immunostaining improves visualization of normal and pathologic astrocytic heterogeneity.
Hand motor activity, cognition, mood, the rest-activity rhythm in dementia. A clustered RCT.
All publications..

Current research

(the most recent research is at the top)
Project leader Proteasomal inhibition by Aβ in astrocytes in Alzheimer?s
Project leader Grasping adult neurogenic astrocytes: towards their recruitment for brain repair
Project leader Astrocyte Biology & Neurodegeneration

Completed research projects

(the most recent research is at the top)
Project leader Protein clearance and protein quality control
Project leader RNA processing and RNA quality control
Project leader Glial-specific proteins in neurons of Alzheimer patients
Co-supervisor Towards gene therapy in amyotrophic lateral sclerosis
Project leader Molecular misreading, transcript stability and +1 protein accumulation in Alzheimer's disease

Classification

A70000 Public health and health care
D21500 Histology, cell biology
D23231 Neurology

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