Dr. M.L. den Boer

Wijzig persoonsdata

• acute
• classificatie
• drugs
• expressie
• farmacodynamiek
• genetica
• kinderoncologie
• kinomics
• leukemie
• medicijn
• microrna
• patienten
• profilering
• proteomics
• resistentie
• targeted
• therapy

Werkzaam als

Publicaties

(de meest recente is bovenaan geplaatst)

MicroRNA characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia

Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia

High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia

Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia

The SWI/SNF chromatin-remodeling complex and glucocorticoid resistance in acute lymphoblastic leukemia

Alle publicaties

Lopende onderzoeksactiviteiten

(de meest recente activiteit is bovenaan geplaatst)
Projectleider	Challenging old dogmas: improved diagnostics and tailored therapy by unraveling biology of acute leukemia in children
Projectleider	Biology of TELAML1-positive ALL in children: role of microenvironment / stromal interaction
Projectleider	Genetic characterization of high risk childhood leukemias for the development of new targeted therapies: focus on MLL gene rearranged ALL
Projectleider	Definition of risk groups in infant acute lymphoblastic leukemia by prospective analysis of immunobiological characteristics, genetic abnormalities, drug resistance and minimal residual disease
Projectleider	Prediction of treatment outcome in infant acute lymphoblastic leukemia

Alle lopende onderzoeksactiviteiten..

Afgesloten onderzoeksactiviteiten

(de meest recente activiteit is bovenaan geplaatst)
Projectleider	Characterization of a novel BCRABL-like subtype with high relapse-risk in pediatric acute lymphoblastic leukemia
Projectleider	Molecular determinants of asparaginase resistance in childhood leukemia
Projectleider	Polymorphism in the glucocorticoid receptor genes and abnormal receptors as determinants of resistance to glucocorticoid induced apoptosis
Projectleider	Clinical application of genome-wide gene expression profiling in pediatric ALL; sub-classification, relapse prediction and causes of drug resistance

Classificatie

A73200	Tweedelijnsgezondheidszorg
D23120	Kanker
D23362	Kindergeneeskunde