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Prof.dr. J.J.M. van Dongen

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Expertise Hemato-oncology; Immunodiagnostics; Lymphoid malignancies; Immunophenotyping; Flow cytometry; Classification of leukemias and lymphomas; Clonality diagnostics; DNA diagnostics; Detection of minimal residual disease (MRD) in leukemia patients; Immunoglobulin genes and T cell receptor genes; Lymphoid differentiation; Primary immunodeficiencies; gene defects; Agammaglobulinemia; Severe combined immunodeficiencies
Expertise (NL) Hemato-oncologie; Immunodiagnostiek; Lymfatische maligniteiten; Immunofenotyperen; Flowcytometrie; Klassificatie van leukemieën en maligne lymfomen; Klonaliteitsdiagnostiek; DNA diagnostiek; Opsporen van kleine aantallen leukemiecellen ("minimal residual disease"); Immunoglobuline genen en T-celreceptorgenen; Lymfatische differentiatie; Primaire immunodeficiënties; Gendefecten; Agammaglobulinemie; Ernstige gecombineerde immunodeficiënties
Digital Author ID info:eu-repo/dai/nl/075056976
Addition Lid Editorial Board van Leukemia en British Journal of Haematology; Referent voor Blood, Bone Marrow Transplantation, Leukemia Research Fund; Voorzitter/coördinator van de PCR-gebaseerde "minimal residual disease"(MRD) studie bij acute lymfatische leukemie (ALL) op de kinderleeftijd van de International BFM Study Group (1992-1997); Voorzitter/coördinator van de moleculaire MRD studies van de BIOMED-1 Concerted Action "Investigation of minimal residual disease (MRD) in acute leukemia: internation

Active as

Professor
Organisation Department of Immunology (EUR)
Chair (EN) Molecular Immunology
Chair (NL) Moleculaire immunologie
Email j. j. m. vandongen -at- erasmusmc. nl

Publications

(the most recent at the top)
IL-7R expression and IL-7 signaling confer a distinct phenotype on developing human B-lineage cells
Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways
Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: Results of the AIEOP-BFM-ALL 2000 study
Automated pattern-guided principal component analysis vs expert-based immunophenotypic classification of B-cell chronic lymphoproliferative disorders: A step forward in the standardization of clinical immunophenotyping
Human peripheral blood B-Cell compartments: A crossroad in B-cell traffic
All publications..

Current research

(the most recent research is at the top)
Project leader Definition of risk groups in infant acute lymphoblastic leukemia by prospective analysis of immunobiological characteristics, genetic abnormalities, drug resistance and minimal residual disease
Project leader Prediction of treatment outcome in infant acute lymphoblastic leukemia
Project leader Diagnosis, classification and treatment evaluation of leukemias and malignant lymphomas
Project leader Lymphoid differentiation and immunodeficiencies

Completed research projects

(the most recent research is at the top)
Project leader Can multi-color flowcytometric immunophenotyping replace PCR-based detection of minimal residual disease in childhood acute lymphoblastic leukemia?
Project leader Identificaton of DNA double-strand break repair genes that are important for maintaining chromosomal stability and ionizing radiation resistance
Project leader Transcription factors and their role in V(D)J recombination processes in normal and malignant T-cell differentiation
Project leader Diagnosis and classification of leukemias and malignant lymphomas and detection of "minimal residual disease"
Project leader Interactions between the immune and (neuro)endocrine systems under physiological conditions and during endocrine or organ-specific autoimmune diseases (immuno-neuroendocrinology')
All completed research..

Classification

A70000 Public health and health care
D21400 Genetics
D21800 Immunology, serology
D23120 Oncology
D23221 Blood and lymphatic diseases

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