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Prof.dr. R. Fodde

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Expertise Hereditary colorectal cancer; Molecular cancer genetics; Adenomatous polyposis coli (APC); beta-catenin; Familial adenomatous polyposis (FAP); Hereditary nonpolyposis colorectal cancer (HNPCC); MSH2; MLH1; Mouse models for intestinal cancer; Mismatch repair; Microsatellite instability (MSI); intestinal stem cells; cancer stem cells
Expertise (NL) Erfelijke dikke darm kanker; moleculaire genetica van kanker; APC; HNPCC; FAP; MSH2; MLH1; beta-catenine; muismodellen voor darmkanker; Mismatch repair; MSI; kanker stamcellen; darm stamcellen
Digital Author ID info:eu-repo/dai/nl/078404363
Addition Hoofd onderzoeksgroep; Projectleider
Grants/prizes NWO-Vici 2002

Active as

Professor
Organisation Department of Pathology (EUR)
Chair (EN) Experimental Pathology
Chair (NL) Experimentele Pathologie
Email r. fodde -at- erasmusmc. nl
URL http://www.erasmusmc.nl/pathologie/research/fodde/

Publications

(the most recent at the top)
Familial adenomatous polyposis-associated desmoids display significantly more genetic changes than sporadic desmoids
β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
Wnt/Β-Catenin and Sex Hormone Signaling in Endometrial Homeostasis and Cancer
A new conditional Apc-mutant mouse model for colorectal cancer
Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome
All publications..

Current research

(the most recent research is at the top)
Project leader Paneth cells in intestinal cancer: supporting act or main feature?
Project leader Neoplastic lesions and chronic inflammation of the gastrointestinal tract
Project leader Carcinomas of the digestive tract

Completed research projects

(the most recent research is at the top)
Project leader Cross-talk of sexhormones and Wnt/ß-catenin signaling in endometrial cancer
Project leader Distinct dosages of Wnt/beta-catenin signaling levels underlie colon and breast cancer stemness
Project leader Cross-talk between receptor tyrosine kinases and ß-catenin signaling during tumor initiation and progression
Project leader Microarray analysis of factors determining apoptosis in human rectal cancers
Project leader Hereditary intestinal tumours
All completed research..

Classification

A70000 Public health and health care
C10000 Biotechnology
D21400 Genetics
D23120 Oncology
D23223 Gastrointestinal system

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