Prof.dr. G.T.J. van der Horst

Update Persondata

• aging
• biological
• cancer
• chronobiology
• circadian
• clock
• health
• models
• mouse
• repair
• rhythms
• transgenesis

Active as

Publications

(the most recent at the top)

Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice

Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice

The potorous cpd photolyase rescues a cryptochrome-deficient mammalian circadian clock

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation

Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging

All publications..

Current research

(the most recent research is at the top)
Project leader	Circadian and cell cycle clock systems in cancer (C5Sys)
Project leader	The photolyase/cryptochrome protein family: delineating structures and functions

Completed research projects

(the most recent research is at the top)
Researcher	Mechanism-based toxicogenomics to develop an in vitro high throughput test for human cancer hazardassessment of (non)-genotoxic chemicals
Project leader	Development of an in vitro assay for the detection of substances capable of slowing down the ageing process
Project leader	Xenogen IVIS(tm)100 imaging system with fluorescence module: imaging of fundamental biological processes in the living mouse using bioluminescence and fluorescence
Project leader	Molecular basis and biological impact of the biological clock
Supervisor	Structural and Functional Analysis of Mammalian Cryptochromes -A Matter of Time

All completed research..

Classification

D21400	Genetics