Dr. H.R. de Jonge

Dr. H.R. de Jonge

Expertise Intracellular signal transduction, in particular through nitric oxide (NO); Atriopeptines; Guanyline; Cyclic GMP; cGMP-dependent protein kinases (cGKs); Protein phosphorylation (proteomics); Regulation of ion transport in epithelial tissues, in particular chloride channels (CFTR) and Na/H exchangers (NHEs); PDZ domain adaptor proteins (NHERF, E3KARP); Pathophysiology of cystic fibrosis (CF) and diarrheal diseases (e.g. cholera); Generation of transgenic mouse models for CF and of KO mice for cGK, NHERF, E3KARP; Use of patch-clamp and Ussing chamber techniques
Expertise (NL) Intracellulaire signaaltransductie, i.h.b. via stikstofoxide (NO); Atriopeptines; Guanyline; Cyclisch GMP; cGMP-afhankelijke eiwitkinases; (cGKs); Eiwitfosforylering (proteomics); Regulatie van ionen transport in epitheelweefsels, i.h.b. chloride kanalen (CFTR); Na/H uitwisselaars (NHE) en anion uitwisselaars (DRA); PDZ domein adaptor eiwitten (NHERF, E3KARP); Pathofysiologie van cystische fibrose (CF) en diarreeziekten (o.a. cholera); Genereren van transgene muismodellen voor CF en van KO muizen voor cGK; NHERF, E3KARP; toepassing van patch-clamp en Ussing kamer technieken
Digital Author ID info:eu-repo/dai/nl/136468837
ISNI ISNI 0000 0003 9553 9756
Addition Member Advisory Board, Flemish Science Organization (FWO), section Medical Biochemistry (Belgium); Member of the Board (treasurer), Dutch Biochemical Society (NVBMB); Editorial advisor, The Biochemical Journal; Editorial board member, J. Cystic Fibrosis; scientific advisor, Canadian Cystic Fibrosis Foundation

Active as

Associate professor
Organisation Department of Gastroenterology and Hepatology (EUR)
Email h. dejonge -at- erasmusmc. nl


Current research

Completed research projects

(the most recent research is at the top)
Project leader Pathophysiology of biomembranes
Project leader Defect enterocytic ATP secretion in cystic fibrosis


D21300 Biochemistry

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