KNAW

Dr. H.R. de Jonge Person

Dr. H.R. de Jonge

Expertise Intracellular signal transduction, in particular through nitric oxide (NO); Atriopeptines; Guanyline; Cyclic GMP; cGMP-dependent protein kinases (cGKs); Protein phosphorylation (proteomics); Regulation of ion transport in epithelial tissues, in particular chloride channels (CFTR) and Na/H exchangers (NHEs); PDZ domain adaptor proteins (NHERF, E3KARP); Pathophysiology of cystic fibrosis (CF) and diarrheal diseases (e.g. cholera); Generation of transgenic mouse models for CF and of KO mice for cGK, NHERF, E3KARP; Use of patch-clamp and Ussing chamber techniques
Expertise (NL) Intracellulaire signaaltransductie, i.h.b. via stikstofoxide (NO); Atriopeptines; Guanyline; Cyclisch GMP; cGMP-afhankelijke eiwitkinases; (cGKs); Eiwitfosforylering (proteomics); Regulatie van ionen transport in epitheelweefsels, i.h.b. chloride kanalen (CFTR); Na/H uitwisselaars (NHE) en anion uitwisselaars (DRA); PDZ domein adaptor eiwitten (NHERF, E3KARP); Pathofysiologie van cystische fibrose (CF) en diarreeziekten (o.a. cholera); Genereren van transgene muismodellen voor CF en van KO muizen voor cGK; NHERF, E3KARP; toepassing van patch-clamp en Ussing kamer technieken
Digital Author ID info:eu-repo/dai/nl/136468837
Addition Member Advisory Board, Flemish Science Organization (FWO), section Medical Biochemistry (Belgium); Member of the Board (treasurer), Dutch Biochemical Society (NVBMB); Editorial advisor, The Biochemical Journal; Editorial board member, J. Cystic Fibrosis; scientific advisor, Canadian Cystic Fibrosis Foundation

Active as

Associate professor
Organisation Department of Gastroenterology and Hepatology (EUR)
Email h. dejonge -at- erasmusmc. nl
URL http://www.erasmusmc.nl/gastrolab/Senior/h.dejonge/?lang=en

Publications

Current research

Completed research projects

(the most recent research is at the top)
Project leader Pathophysiology of biomembranes
Project leader Defect enterocytic ATP secretion in cystic fibrosis

Classification

D21300 Biochemistry

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