Person
The development of new drugs is increasingly costly and ineffective. Most time and money is accounted for by late-stage clinical trials that aim to confirm the safety and efficacy of the investigated drug. To assure the continued arrival of new and affordable therapies, it is therefore essential to
Cardiovascular disease (CVD) is the leading cause of death worldwide. Although the disease becomes apparent later in life, atherosclerosis already begins early in life. Currently it remains largely unknown whether CVD risk factors impact the vascular walls already early in childhood. Moreover, CVD r
Safety surveillance is important during the entire life cycle of a drug. Pre-marketing trials have been shown to be ineffective in establishing the full safety profile of the drug, mainly due to their relatively small sample size and characteristics of the patients, which are usually younger and hea
Cardiovascular disease is still the leading cause of morbidity and mortality worldwide.1 The majority of cardiovascular disease events is caused by atherosclerosis. Atherosclerosis is a slow and progressive disease of the arterial wall that is on the pathway between the effects of exposure to risk f
For drugs that are registered on the market, efficacy was proven on a population level. However, on an individual level, most drugs have a different effect in different patients. They may fail to work in some patients or cause serious side effects. Pharmacogenetic research studies the contribution
The aim of this thesis is to assess diagnostic strategies in patients suspected of heart failure (defined as a syndrome in which patients suffer from the inability of the heart to supply sufficient blood flow to meet the needs of the body) in primary care. B-type Natriuretic Peptide (BNP or NT-proBN
Honger en chronische ziekten zijn belangrijke wereldwijde gezondheidsproblemen. Eerder onderzoek leverde aanwijzingen op dat deze problemen met elkaar samenhangen: kortdurende extreme honger tijdens belangrijke perioden van groei en ontwikkeling kan nadelige effecten op de gezondheid later in het le
Carla Zomer behandelt de noodzaak van chirurgie en andere interventies bij volwassenen met een aangeboren hartaandoening. Zomer zag dat mannen vaker chirurgie ondergaan en lagere overlevingskansen hebben na heroperaties dan vrouwen. Ze keek ook naar het sociaal functioneren van volwassenen met een a
The co-existence of high blood pressure and diabetes dramatically and synergistically increases the risk of microvascular and macrovascular complications. In order to reduce morbidity and mortality in these high risk patients, optimal blood pressure goals should be achieved. Angiotensin-converting e
This thesis focuses on the disorder we know as schizophrenia. Although there is treatment for schizophrenia in the form of anti-psychotic drugs, not all patients respond well to this treatment. A large part of patients will have remaining symptoms for the rest of their lives. A number of hypotheses
Go to page top
Go back to contents
Go back to site navigation