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Prof.dr. M.M.B. Breteler Persoon

Prof.dr. M.M.B. Breteler

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  • Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure (2011)Open access

    Auteurs:Wain, L.V.; Verwoert, G.C.; O'Reilly, P.F.; Shi, G.; Johnson, T.; Bochud, M.; Rice, K.; Henneman, P.; Smith, A.V.; Ehret, G.B.; Amin, N.; Larson, M.G.; Mooser, V.; Hadley, D.; Dörr, M.; Bis, J.C.; Aspelund, T.; Esko, T.; Janssens, A.C.J.W.; Zhao, J.H.; Heath, S.C.; Laan, M.; Fu, J.; Pistis, G.; Luan, J.; Lucas, G.; Pirastu, N.; Pichler, I.; Jackson, A.U.; Webster, R.J.; Zhang, F.F.; Peden, J.; Schmidt, R.; Tanaka, T.; Campbell, H.; Igl, W.; Milaneschi, Y.; Hottenga, J.J.; Vitart, V.; Chasman, D.I.; Trompet, S.; Bragg-Gresham, J.L.; Alizadeh, B.Z.; Chambers, J.C.; Guo, X.; Lehtimäki, T.; Kuhnel, B.; Lopez, L.M.; Polasek, O.; Boban, M.; Nelson, C.P.; Morrison, A.C.; Pihur, V.; Ganesh, S.K.; Hofman, A.; Kundu, S.; Mattace-Raso, F.U.S.; Rivadeneira Ramirez, F.; Sijbrands, E.J.G.; Uitterlinden, A.G.; Hwang, S.J.; Vasan, R.S.; Wang, Y.A.; Bergmann, S.; Vollenweider, P.; Waeber, G.; Laitinen, J.; Pouta, A.; Zitting, P.; McArdle, W.L.; Kroemer, H.K.; Völker, U.; Völzke, H.; Glazer, N.L.; Taylor, K.D.; Harris, T.B.; Alavere, H.; Haller, T.; Keis, A.; Tammesoo, M.L.; Aulchenko, Y.S.; Khaw, K-T.; Galan, P.; Hercberg, S.; Lathrop, G.M.; Eyheramendy, S.; Org, E.; Sõber, S.; Lu, X.; Nolte, I.M.; Penninx, B.W.J.H.; Corre, T.; Masciullo, C.; Sala, C.; Groop, L.; Voight, B.F.; Melander, O.; O'Donnell, C.J.; Salomaa, V.; D, A.P.; Fabretto, A.; Faletra, F.; Ulivi, S.; Del Greco M, F.; Facheris, M.F.; Collins, F.S.; Bergman, R.N.; Beilby, J.P.; Hung, J.; Musk, A.W.; Mangino, M.; Shin, S.Y.; Soranzo, N.; Watkins, H.; Goel, A.; Hamsten, A.; Gider, P.; Loitfelder, M.; Zeginigg, M.; Hernandez, D.G.; Najjar, S.S.; Navarro, P.; Wild, S.H.; Corsi, A.M.; Singleton, A.; Geus, E.J.C. de; Willemsen, G.A.H.M.; Parker, A.N.; Rose, L.M.; Buckley, B.M.; Stott, D.J.; Orrù, M.; Uda, M.; Klauw, M.M. van der; Li, X.; Scott, J.; Chen, Y.D.I.; Burke, G.L.; Kähönen, M.; Viikari, J.; Döring, A.; Meitinger, T.; Davis, G.S.; Starr, J.M.; Emilsson, V.; Plump, A.S.; Lindeman, J.H.; Hoen, P.A.C.T.; König, I.R.; Felix, J.F.; Clarke, R.; Hopewell, J.; Ongen, H.; Breteler, M.M.B.; Debette, S.; DeStefano, A.L.; Fornage, M.; Mitchell, G.F.; Holm, H.; Stefansson, K.; Thorleifsson, G.; Thorsteinsdottir, U.; Samani, N.J.; Preuss, M.; Rudan, I.; Hayward, C.; Deary, I.J.; Wichmann, H.E.; Raitakari, O.; Palmas, W.; Kooner, J.S.; Stolk, R.P.; Jukema, J.W.; Wright, A.F.; Boomsma, D.I.; Bandinelli, S.; Gyllensten, U.; Wilson, J.F.; Ferrucci, L.; Farrall, M.; Spector, T.D.; Palmer, L.J.; Tuomilehto, J.; Pfeufer, A.; Gasparini, P.; Siscovick, D.S.; Altshuler, D.; Loos, R.J.F.; Toniolo, D.; Snieder, H.; Gieger, C.; Meneton, P.; Wareham, N.J.; Oostra, B.A.; Metspalu, A.; Launer, L.J.; Rettig, R.; Strachan, D.P.; Beckmann, J.S.; Witteman, J.C.M.; Erdmann, J.; Willems van Dijk, J.A.P.; Boerwinkle, E.; Boehnke, M.; Ridker, P.M.; Järvelin, M.R.; Chakravarti, A.; Gudnason, V.; Newton-Cheh, C.; Levy, D.; Arora, P.; Munroe, P.; Psaty, B.M.; Caulfield, M.; Rao, D.C.; Elliott, P.; Tikka-Kleemola, P.; Abecasis, G.R.; Barroso, I.; Erasmus MC: University Medical Center Rotterdam
    In:Nature Genetics, 43(10), 1005 - 1012. ISSN 1061-4036.

    Samenvatting:

    Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we ident

  • Genome-wide association studies of cerebral white matter lesion burden (2011)

    Auteurs:Fornage, M. (Myriam); Debette, S. (Stéphanie); Bis, J.C. (Joshua); Schmidt, R. (Reinhold); Ikram, M.A. (Mohammed Arfan); Dufouil, C. (Carole); Sigurdsson, S. (Stefan); Lumley, T. (Thomas); DeStefano, A.L. (Anita); Fazekas, F. (Franz); Vrooman, H.A. (Henri); Shibata, D.K. (Dean); Maillard, P. (Pauline); Zijdenbos, A.P.; Smith, A.V. (Albert Vernon); Gudnason, H. (Haukur); Boer, de R. (Renske); Cushman, M. (Mary Ann); Mazoyer, B. (Bernard); Heiss, G. (Gerardo); Vernooij, M.W. (Meike); Enzinger, C. (Christian); Glazer, N.L. (Nicole); Beiser, A. (Alexa); Knopman, D.S. (David); Cavalieri, M. (Margherita); Niessen, W.J. (Wiro); Harris, T.B. (Tamara); Petrovic, K. (Katja); Lopez, O.L. (Oscar); Au, R. (Rhoda); Lambert, J.C. (Jean Charles); Hofman, A. (Albert); Gottesman, R.F. (Rebecca); Garcia, M. (Melissa); Heckbert, S.R. (Susan); Atwood, L.D. (Larry); Catellier, D.J. (Diane); Uitterlinden, A.G. (André); Yang, Q. (Qiong Fang); Aspelund, T. (Thor); Romero, J.R. (Jose Rafael); Rice, K. (Kenneth); Taylor, K.D. (Kent); Nalls, M.A. (Michael); Rotter, J.I. (Jerome); Sharrett, R. (Richey); Tikka-Kleemola, P. (Päivi); Amouyel, P. (Philippe); Wolf, P.A. (Philip); Lugt, van der A. (Aad); Boerwinkle, E. (Eric); Psaty, B.M. (Bruce); Seshadri, S. (Sudha); Tzourio, C. (Christophe); Breteler, M.M.B. (Monique); Mosley, T.H. (Thomas); Longstreth, W.T.; DeCarli, C. (Charles); Launer, L.J. (Lenore)
    In:Annals of Neurology, 69(6), 928 - 939. ISSN 0364-5134.

    Samenvatting:

    Objective: White matter hyperintensities (WMHs) detectable by magnetic resonance imaging are part of the spectrum of vascular injury associated with aging of the brain and are thought to reflect ischemic damage to the small deep cerebral vessels. WMHs are associated with an increased risk of cogniti

  • The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project (2010)Open access

    Auteurs:Combarros, O. (Onofre); Warden, D.R. (Donald); Hammond, N. (Naomi); Cortina-Borja, M. (Mario); Belbin, O. (Olivia); Lehmann, M.G. (Michael); Wilcock, G.K. (Gordon); Brown, K. (Kristelle); Kehoe, P.G. (Patrick); Barber, R. (Rachel); Coto, E. (Eliecer); Alvarez, V. (Victoria); Deloukas, P. (Panagiotis); Gwilliam, R. (Rhian); Heun, R. (Reinhard); Kölsch, H. (Heike); Mateo, I. (Ignacio); Oulhaj, A. (Abderrahim); Arias-Vásquez, A. (Alejandro); Schuur, M. (Maaike); Aulchenko, Y.S. (Yurii); Ikram, M.A. (Mohammed Arfan); Breteler, M.M.B. (Monique); Duijn, van C.M. (Cock); Morgan, K. (Kevin); Smith, A.D. (David)
    In:B M C Medical Genetics, 11(1). ISSN 1471-2350.

    Samenvatting:

    Background: The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD). Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and poly

  • Heart failure and the risk of stroke: the Rotterdam Study (2010)Open access

    Auteurs:Alberts, V.P.; Bos, M.J. (Michiel); Koudstaal, P.J. (Peter); Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline); Stricker, B.H.Ch. (Bruno); Breteler, M.M.B. (Monique)
    In:European Journal of Epidemiology, 25(11), 807 - 812. ISSN 0393-2990.

    Samenvatting:

    Patients with heart failure used to have an increased risk of stroke, but this may have changed with current treatment regimens. We assessed the association between heart failure and the risk of stroke in a population-based cohort that was followed since 1990. The study uses the cohort of the Rotter

  • A prospective analysis of elevated fasting glucose levels and cognitive function in older people: Results from PROSPER and the Rotterdam Study (2010)

    Auteurs:Euser, S.M. (Sjoerd); Sattar, N. (Naveed); Witteman, J.C.M. (Jacqueline); Bollen, E.L.E.M. (Eduard); Sijbrands, E.J.G. (Eric); Hofman, A. (Albert); Perry, I.J. (Ivan); Breteler, M.M.B. (Monique); Westendorp, R.G.J. (Rudi)
    In:Diabetes, 59(7), 1601 - 1607. ISSN 0012-1797.

    Samenvatting:

    OBJECTIVE - To investigate the relationship between fasting glucose levels, insulin resistance, and cognitive impairment in old age. Diabetes is associated with cognitive impairment in older people. However, the link between elevated fasting glucose levels and insulin resistance in nondiabetic indiv

  • A 10-year follow-up of hippocampal volume on magnetic resonance imaging in early dementia and cognitive decline (2010)

    Auteurs:Heijer, den T. (Tom); Lijn, van der F. (Fedde); Koudstaal, P.J. (Peter); Hofman, A. (Albert); Lugt, van der A. (Aad); Krestin, G.P. (Gabriel); Niessen, W.J. (Wiro); Breteler, M.M.B. (Monique)
    In:Brain: a journal of neurology, 133(4), 1163 - 1172. ISSN 0006-8950.

    Samenvatting:

    Hippocampal atrophy is frequently observed on magnetic resonance images from patients with Alzheimer's disease and persons with mild cognitive impairment. Even in asymptomatic elderly, a small hippocampal volume on magnetic resonance imaging is a risk factor for developing Alzheimer's disease. Howev

  • Genome-wide association studies of mri-defined brain infarcts: Meta-analysis from the charge consortium (2010)Open access

    Auteurs:Debette, S. (Stéphanie); Bis, J.C. (Joshua); Fornage, M. (Myriam); Schmid, H.A. (Herbert); Ikram, M.A. (Mohammed Arfan); Sigurdsson, S. (Stefan); Heiss, G. (Gerardo); Struchalin, M.V. (Maksim); Smith, A.V. (Albert Vernon); Lugt, van der A. (Aad); DeCarli, C. (Charles); Lumley, T. (Thomas); Knopman, D.S. (David); Enzinger, C. (Christian); Eiriksdottir, G. (Gudny); Koudstaal, P.J. (Peter); DeStefano, A.L. (Anita); Psaty, B.M. (Bruce); Dufouil, C. (Carole); Catellier, D.J. (Diane); Fazekas, F. (Franz); Aspelund, T. (Thor); Aulchenko, Y.S. (Yurii); Beiser, A. (Alexa); Rotter, J.I. (Jerome); Tzourio, C. (Christophe); Shibata, D.K. (Dean); Tscherner, M. (Maria); Harris, T.B. (Tamara); Rivadeneira Ramirez, F. (Fernando); Atwood, L.D. (Larry); Rice, K. (Kenneth); Gottesman, R.F. (Rebecca); Buchem, van M.A. (Mark); Uitterlinden, A.G. (André); Kelly-Hayes, M. (Margaret); Cushman, M. (Mary Ann); Zhu, Y. (Yicheng); Boerwinkle, E. (Eric); Gudnason, V. (Vilmundur); Hofman, A. (Albert); Romero, J.R. (Jose Rafael); Breteler, M.M.B. (Monique); Schmidt, R. (Reinhold); Launer, L.J. (Lenore); Longstreth, W.T.
    In:Stroke, 41(2), 210 - 217. ISSN 0039-2499.

    Samenvatting:

    Background and Purpose-Previous studies examining genetic associations with MRI-defined brain infarct have yielded inconsistent findings. We investigated genetic variation underlying covert MRI infarct in persons without histories of transient ischemic attack or stroke. We performed meta-analysis of

  • Genomewide association studies of stroke (2009)Open access

    Auteurs:Ikram, M.A. (Mohammed Arfan); Seshadri, S. (Sudha); Bis, J.C. (Joshua); Fornage, M. (Myriam); DeStefano, A.L. (Anita); Aulchenko, Y.S. (Yurii); Debette, S. (Stéphanie); Lumley, T. (Thomas); Folsom, A.R. (Aaron); Herik, van den E.G. (Evita); Bos, M.J. (Michiel); Beiser, A. (Alexa); Cushman, M. (Mary Ann); Launer, L.J. (Lenore); Shahar, E. (Eyal); Struchalin, M.V. (Maksim); Du, Y. (Yangchun); Glazer, N.L. (Nicole); Rosamond, W.D. (Wayne); Rivadeneira Ramirez, F. (Fernando); Kelly-Hayes, M. (Margaret); Lopez, O.L. (Oscar); Coresh, J. (Josef); Hofman, A. (Albert); DeCarli, C. (Charles); Heckbert, S.R. (Susan); Koudstaal, P.J. (Peter); Yang, Q. (Qiong Fang); Smith, N.L. (Nicholas); Kase, C.S. (Carlos); Rice, K. (Kenneth); Haritunians, T. (Talin); Forey, F.; Kort, de P.L.M.; Taylor, K.D. (Kent); Lau, de L.M.L. (Lonneke); Oostra, B.A. (Ben); Uitterlinden, A.G. (André); Rotter, J.I. (Jerome); Boerwinkle, E. (Eric); Psaty, B.M. (Bruce); Mosley, T.H. (Thomas); Duijn, van C.M. (Cock); Breteler, M.M.B. (Monique); Longstreth, W.T.; Wolf, P.A. (Philip)
    In:New England Journal of Medicine, 360(17), 1718 - 1728. ISSN 0028-4793.

    Samenvatting:

    BACKGROUND: The genes underlying the risk of stroke in the general population remain undetermined. METHODS: We carried out an analysis of genomewide association data generated from four large cohorts composing the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, including 19,

  • Orthostatic hypotension and risk of cardiovascular disease in elderly people: The Rotterdam study (2008)Open access

    Auteurs:Verwoert, G.C. (Germaine); Mattace Raso, F.U.S. (Francesco); Heeringa, J. (Jan); Stricker, B.H.Ch. (Bruno); Breteler, M.M.B. (Monique); Witteman, J.C.M. (Jacqueline); Hofman, A. (Albert)
    In:American Geriatrics Society. Journal, 56(10), 1816 - 1820. ISSN 0002-8614.

    Samenvatting:

    OBJECTIVES: To determine the prognostic role of orthostatic hypotension for cardiovascular disease (CVD) and all-cause mortality in elderly people. DESIGN: Prospective study. SETTING: Community based. PARTICIPANTS: Five thousand sixty-four subjects from the Rotterdam study aged 55 and older. MEASURE

  • Cerebral microbleeds: Accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection (2008)

    Auteurs:Vernooij, M.W. (Meike); Ikram, M.A. (Mohammed Arfan); Wielopolski, P.A. (Piotr); Krestin, G.P. (Gabriel); Breteler, M.M.B. (Monique); Lugt, van der A. (Aad)
    In:Radiology, 248(1), 272 - 277. ISSN 0033-8419.

    Samenvatting:

    The purpose of this study was to prospectively compare high-spatial- resolution accelerated three-dimensional (3D) T2*-weighted gradient-recalled-echo (GRE) magnetic resonance (MR) images with conventional two-dimensional (2D) T2*-weighted GRE MR images for the depiction of cerebral microbleeds. Aft

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