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Prof.dr. C.M. van Duijn Persoon

Prof.dr. C.M. van Duijn

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  • An R package "VariABEL" for genome-wide searching of potentially interacting loci by testing genotypic variance heterogeneity (2012)

    Auteurs:Struchalin, M.V. (Maksim); Amin, N. (Najaf); Eilers, P.H. (Paul); Duijn, van C.M. (Cock); Aulchenko, Y.S. (Yurii)
    In:BMC Genetics, 13. ISSN 1471-2156.

    Samenvatting:

    Background: Hundreds of new loci have been discovered by genome-wide association studies of human traits. These studies mostly focused on associations between single locus and a trait. Interactions between genes and between genes and environmental factors are of interest as they can improve our unde

  • Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking (2011)

    Auteurs:Terracciano, A.; Esko, T. (Tõnu); Sutin, A.R.; Moor, de M.H.M.; Meirelles, O.; Zhu, G.; Tanaka, T.; Giegling, I. (Ina); Nutile, T.; Realo, A.; Allik, J.; Hansell, N.K.; Wright, M.J.; Montgomery, G.W.; Willemsen, G.A.H.M. (Gonneke); Hottenga, J.J.; Friedl, M.; Ruggiero, D.; Sorice, R.; Sanna, S.; Cannas, A.; Räikkönen, K.; Widen, E. (Elisabeth); Palotie, A. (Aarno); Eriksson, J.G.; Cucca, F. (Francesco); Krueger, R.F.; Lahti, J.; Luciano, M. (Michelle); Smoller, J.W.; Duijn, van C.M. (Cock); Boomsma, D.I. (Dorret); Ciullo, M.; Costa Jr, P.T.; Ferrucci, L.; Martin, N.G. (Nicholas); Metspalu, A. (Andres); Rujescu, D. (Dan); Schlessinger, D.; Uda, M.; Abecasis, G.R. (Gonçalo)
    In:Translational Psychiatry, 1. ISSN 2158-3188.

    Samenvatting:

    The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures

  • The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data (2011)

    Auteurs:Middeldorp, C.M. (Christel); Moor, de M.H.M.; McGrath, L.M.; Gordon, S.D.; Blackwood, D.H.; Costa Jr, P.T.; Terracciano, A.; Krueger, R.F.; Geus, de E.J.C. (Eco); Nyholt, D.R. (Dale); Tanaka, T.; Esko, T. (Tõnu); Madden, P.A.F.; Derringer, J.; Amin, N. (Najaf); Willemsen, G.A.H.M. (Gonneke); Hottenga, J.J.; Distel, M.A. (Marijn); Uda, M.; Sanna, S.; Spinhoven, P.; Hartman, C.A.; Ripke, S. (Stephan); Sullivan, P.F.; Realo, A.; Allik, J.; Heath, A.C.; Pergadia, M.L. (Michele); Agrawal, A. (Arpana); Lin, P.; Grucza, R.; Widen, E. (Elisabeth); Cousminer, D.L. (Diana); Eriksson, J.G.; Palotie, A. (Aarno); Barnett, J.H.; Lee, P.H.; Luciano, M. (Michelle); Tenesa, A. (Albert); Davies, G.; Lopez, L.M.; Hansell, N.K.; Medland, S.E.; Ferrucci, L.; Schlessinger, D.; Montgomery, G.W.; Wright, M.J.; Janssens, A.C.J.W. (Cécile); Oostra, B.A. (Ben); Metspalu, A. (Andres); Deary, I.J.; Räikkönen, K.; Bierut, L.J. (Laura); Martin, N.G. (Nicholas); Wray, N.R. (Naomi); Duijn, van C.M. (Cock); Smoller, J.W.; Penninx, B.W.J.H. (Brenda); Boomsma, D.I. (Dorret); Abecasis, G.R. (Gonçalo); Aulchenko, Y.S. (Yurii)
    In:Translational Psychiatry, 1. ISSN 2158-3188.

    Samenvatting:

    The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as predisposing personality traits. For example, high neuroticism is related to both disorders, w

  • The Rotterdam Study: 2012 objectives and design update (2011)Open access

    Auteurs:Hofman, A. (Albert); Duijn, van C.M. (Cock); Franco, O.H. (Oscar); Ikram, M.A. (Mohammed Arfan); Janssen, H.L.A. (Harry); Klaver, C.C.W. (Caroline); Kuipers, E.J. (Ernst); Nijsten, T.E.C. (Tamar); Stricker, B.H.Ch. (Bruno); Tiemeier, H. (Henning); Uitterlinden, A.G. (André); Vernooij, M.W. (Meike); Witteman, J.C.M. (Jacqueline)
    In:European Journal of Epidemiology, 2011, 1 - 30. ISSN 0393-2990.

    Samenvatting:

    Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, oncological, and respiratory diseases. As of 2008, 14,926 subjects a

  • Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM (2011)

    Auteurs:Amin, N. (Najaf); Byrne, E.M. (Elaine); Johnson, J.L. (Joel L.); Chenevix-Trench, G. (Georgia); Walter, S. (Stefan); Nolte, I.M. (Ilja); Vink, J. (Jaap); Rawal, R. (R.); Mangino, M. (Massimo); Teumer, A. (Alexander); Keers, J.C. (J. C.); Verwoert, G.C. (Germaine); Baumeister, S. (S.); Biffar, R. (Reiner); Petersmann, A. (Astrid); Dahmen, N. (N.); Doering, A. (Angela); Isaacs, A. (Aaron); Broer, L. (Linda); Wray, N.R. (Naomi); Montgomery, G.W.; Levy, D. (Daniel); Psaty, B.M. (Bruce); Gudnason, V. (Vilmundur); Chakravarti, A. (Aravinda); Sulem, P. (Patrick); Gudbjartsson, D.F. (Daniel); Kiemeney, L.A. (Lambertus); Thorsteinsdottir, U. (Unnur); Stefansson, K. (Kari); Rooij, van F.J.A. (Frank); Aulchenko, Y.S. (Yurii); Hottenga, J.J.; Rivadeneira Ramirez, F. (Fernando); Hofman, B.; Uitterlinden, A.G. (André); Hammond, C.J. (Christopher); Shin, S.Y. (So Youn); Ikram, M.A. (Mohammed Arfan); Witteman, J.C.M. (Jacqueline); Janssens, A.C.J.W. (Cécile); Snieder, H. (Harold); Tiemeier, H. (Henning); Wolfenbuttel, B.H.R.; Oostra, B.A. (Ben); Heath, A.C.; Wichmann, E.; Spector, T.D. (Timothy); Grabe, H.J. (H. J.); Boomsma, D.I. (Dorret); Martin, N.G.; Duijn, van C.M. (Cock)
    In:Molecular Psychiatry. ISSN 1359-4184.

    Samenvatting:

    Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N=18 176) and sought replication of our top findings in a further 7929 individuals. We also performed a gene expression analysis tr

  • Strengthening the reporting of genetic risk prediction studies: The GRIPS statement (2011)Open access

    Auteurs:Janssens, A.C.J.W. (Cécile); Duijn, van C.M. (Cock); Ioannidis, J.P.A. (John); Tikka-Kleemola, P. (Päivi); Little, J. (Julian); Khoury, M.J. (Muin Joseph)
    In:European Journal of Epidemiology, 26(4), 255 - 259. ISSN 0393-2990.

    Samenvatting:

    The rapid and continuing progress in gene discovery for complex diseases is fueling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but the quality and completeness of

  • Association of an APOC3 promoter variant with type 2 diabetes risk and need for insulin treatment in lean persons (2011)Open access

    Auteurs:Hoek, M. van; Herpt, T.W. van; Dehghan, A.; Hofman, A.; Lieverse, A.; Duijn, C.M. van; Witteman, J.C.M.; Sijbrands, E.J.G.
    In:Diabetologia: clinical and experimental diabetes and metabolism, 1 - 8. ISSN 0012-186x.

    Samenvatting:

    Aims/hypothesis: An APOC3 promoter haplotype has been previously associated with type 1 diabetes. In this population-based study, we investigated whether APOC3 polymorphisms increase type 2 diabetes risk and need for insulin treatment in lean participants. Methods: In the Rotterdam Study, a populati

  • Strengthening the reporting of genetic risk prediction studies: The GRIPS statement (2011)Open access

    Auteurs:Janssens, A.C.J.W. (Cécile); Ioannidis, J.P.A. (John); Duijn, van C.M. (Cock); Little, J. (Julian); Khoury, M.J. (Muin Joseph)
    In:PLoS Medicine, 8(3), 1 - 4. ISSN 1549-1277.

    Samenvatting:

    Summary Points * The rapid and continuing progress in gene discovery for complex diseases is fueling interest in the potential application of genetic risk models for clinical and public health practice. * The number of studies assessing the predictive ability is steadily increasing, but the qu

  • Meta-analysis of genome-wide association studies for personality (2010)

    Auteurs:Moor, de M.H.M.; Costa Jr, P.T.; Terracciano, A.; Krueger, R.F.; Geus, de E.J.C. (Eco); Toshiko, T.; Penninx, B.W.J.H. (Brenda); Esko, T.; Madden, P.A.F.; Derringer, J.; Amin, N. (Najaf); Willemsen, G.A.H.M. (Gonneke); Hottenga, J.J.; Distel, M.A. (Marijn); Uda, M.; Sanna, S.; Spinhoven, P.; Hartman, C.A.; Sullivan, P.F. (Patrick); Realo, A.; Allik, J.; Heath, A.C.; Pergadia, M.L.; Lin, P.; Grucza, R.; Nutile, T.; Ciullo, M.; Rujescu, D. (Dan); Giegling, I. (Ina); Konte, B.; Widen, E. (Elisabeth); Cousminer, D.L. (Diana); Eriksson, J.G.; Palotie, A.; Peltonen, L.; Luciano, M. (Michelle); Tenesa, A. (Albert); Davies, G.; Lopez, L.M.; Hansell, N.K.; Medland, S.E.; Ferrucci, L.; Schlessinger, D.; Montgomery, G.W.; Wright, M.J.; Aulchenko, Y.S. (Yurii); Janssens, A.C.J.W. (Cécile); Oostra, B.A. (Ben); Metspalu, A. (Andres); Deary, I.J.; Räikkönen, K.; Bierut, L.J. (Laura); Martin, N.G.; Duijn, van C.M. (Cock); Boomsma, D.I. (Dorret); Abecasis, G.R. (Gonçalo); Agrawal, A. (Arpana)
    In:Molecular Psychiatry. ISSN 1359-4184.

    Samenvatting:

    Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA)

  • The ERCC6 Gene and Age-Related Macular Degeneration (2010)Open access

    Auteurs:Baas, D.C. (Dominique); Despriet, D.D.G. (Dominique); Gorgels, T.G.M.F. (Theo); Bergeron-Sawitzke, J. (Julie); Uitterlinden, A.G. (André); Hofman, A. (Albert); Duijn, van C.M. (Cock); Merriam, J.E. (Joanna); Smith, R.T. (Theodore); Barile, G.R. (Gaetano); Brink, ten J.B. (Jacoline); Vingerling, J.R. (Hans); Klaver, C.C.W. (Caroline); Allikmets, R. (Rando); Dean, M. (Michael Emmans); Bergen, A.A.B. (Arthur)
    In:PLoS ONE, 5(11), 1 - 9. ISSN 1932-6203.

    Samenvatting:

    Background: Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the developed countries and is caused by both environmental and genetic factors. A recent study (Tuo et al., PNAS) reported an association between AMD and a single nucleotide polymorphism (SNP) (rs

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