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Prof.dr. N.S. Macklon

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  • Risk of borderline and invasive ovarian tumours after ovarian stimulation for in vitro fertilization in a large Dutch cohort (2011)Open access

    Auteurs:Leeuwen, van F.E.; Klip, H.; Mooij, T.M.; Swaluw, van de A.M.G.; Lambalk, C.B.; Kortman, M.; Laven, J.S.E. (Joop); Jansen, C.A.M.; Helmerhorst, F.M.; Cohlen, B.J.; Willemsen, W.N.P. (Wim); Smeenk, J.M.J.; Simons, A.H.M.; Veen, van der F.; Evers, J.L.H. (Johannes); Dop, van P.A.; Macklon, N.S. (Nick); Burger, C.W. (Curt)
    In:Human Reproduction, 26(12), 3456 - 3465. ISSN 0268-1161.

    Samenvatting:

    Background: Long-term effects of ovarian stimulation for IVF on the risk of ovarian malignancies are unknown.Methods: We identified a nationwide historic cohort of 19 146 women who received IVF treatment in the Netherlands between 1983 and 1995, and a comparison group of 6006 subfertile women not tr

  • The fate of the mosaic embryo: Chromosomal constitution and development of Day 4, 5 and 8 human embryos (2010)

    Auteurs:Santos, M.A.; Teklenburg, G. (Gijs); Macklon, N.S. (Nick); Opstal, van D. (Diane); Schuring-Blom, G.H. (Heleen); Krijtenburg, P.J.; Vreeden-Elbertse, de J. (Johanna); Fauser, B.C.J.M. (Bart); Baart, E.B. (Esther)
    In:Human Reproduction, 25(8), 1916 - 1926. ISSN 0268-1161.

    Samenvatting:

    Background: Post-zygotic chromosome segregation errors are very common in human embryos after in vitro fertilization, resulting in mosaic embryos. However, the significance of mosaicism for the developmental potential of early embryos is unknown. We assessed chromosomal constitution and development

  • The different shades of mammalian pluripotent stem cells (2010)Open access

    Auteurs:Kuijk, E.W.; Lopes, S.M.; Geijsen, N.; Macklon, N.S.; Roelen, B.A.J.
    In:Human Reproduction Update, 17, 254 - 271. ISSN 1355-4786.

    Samenvatting:

    BACKGROUND Pluripotent stem cells have been derived from a variety of sources such as from the inner cell mass of preimplantation embryos, from primordial germ cells, from teratocarcinomas and from male germ cells. The recent development of induced pluripotent stem cells demonstrates that somatic ce

  • Homocysteine metabolism in the pre-ovulatory follicle during ovarian stimulation (2008)Open access

    Auteurs:Boxmeer, J.C. (Jolanda); Steegers-Theunissen, R.P.M. (Regine); Lindemans, J. (Jan); Wildhagen, M.F. (Mark); Martini, E. (Elena); Steegers, E.A.P. (Eric); Macklon, N.S. (Nick)
    In:Human Reproduction, 23(11), 2570 - 2576. ISSN 0268-1161.

    Samenvatting:

    BACKGROUND: Ovarian stimulation gives rise to supraphysiological estradiol levels, which may affect oocyte quality. This study aims to investigate whether ovarian stimulation deranges the homocysteine pathway thereby affecting the pre-ovulatory follicle. METHODS: Blood samples were collected on cycl

  • Why do couples drop-out from IVF treatment? A prospective cohort study (2008)

    Auteurs:Verberg, M.F.G.; Eijkemans, M.J.C. (René); Heijnen, E.M.; Broekmans, F.J.M. (Frank); Klerk, de C. (Cora); Fauser, B.C.J.M. (Bart); Macklon, N.S. (Nick)
    In:Human Reproduction, 23(9), 2050 - 2055. ISSN 0268-1161.

    Samenvatting:

    BACKGROUND: Cumulative IVF pregnancy rates are compromised by the large number of couples who drop-out of treatment before achieving pregnancy. The aim of this study was to identify the role of the treatment strategy applied, and potential other factors that influence the decision of couples to disc

  • Does confined placental mosaicism account for adverse perinatal outcomes in IVF pregnancies? (2008)

    Auteurs:Jacod, B.C.; Lichtenbelt, K.D. (Klaske); Schuring-Blom, G.H. (Heleen); Laven, J.S.E. (Joop); Opstal, van D. (Diane); Eijkemans, M.J.C. (René); Macklon, N.S. (Nick)
    In:Human Reproduction, 23(5), 1107 - 1112. ISSN 0268-1161.

    Samenvatting:

    BACKGROUND: IVF singletons have poorer perinatal outcomes than singletons from spontaneous conceptions. This may be due to the influence of ovarian stimulation on the chromosomal constitution of the embryos which could be translated into localized chromosomal anomalies in the placenta. The aim of th

  • Cost-effectiveness of a mild compared with a standard strategy for IVF: A randomized comparison using cumulative term live birth as the primary endpoint (2008)

    Auteurs:Polinder, S. (Suzanne); Heijnen, E.M.; Macklon, N.S. (Nick); Habbema, J.D.F. (Dik); Fauser, B.C.J.M. (Bart); Eijkemans, M.J.C. (René)
    In:Human Reproduction, 23(2), 316 - 323. ISSN 0268-1161.

    Samenvatting:

    BACKGROUND: Conventional ovarian stimulation and the transfer of two embryos in IVF exhibits an inherent high probability of multiple pregnancies, resulting in high costs. We evaluated the cost-effectiveness of a mild compared with a conventional strategy for IVF. METHODS: Four hundred and four pati

  • Low negative affect prior to treatment is associated with a decreased chance of live birth from a first IVF cycle (2008)

    Auteurs:Klerk, de C. (Cora); Hunfeld, J.A.M. (Joke); Heijnen, E.M.; Eijkemans, M.J.C. (René); Fauser, B.C.J.M. (Bart); Passchier, J. (Jan); Macklon, N.S. (Nick)
    In:Human Reproduction, 23(1), 112 - 116. ISSN 0268-1161.

    Samenvatting:

    BACKGROUND: Psychological variables, such as anxiety and depression, may have a negative impact on IVF outcomes, but the evidence remains inconclusive. Previous studies have usually measured a single psychological parameter with clinical pregnancy as the outcome. The objective of the current study w

  • The psychological impact of IVF failure after two or more cycles of IVF with a mild versus standard treatment strategy (2007)

    Auteurs:Klerk, de C. (Cora); Macklon, N.S. (Nick); Heijnen, E.M.; Eijkemans, M.J.C. (René); Fauser, B.C.J.M. (Bart); Passchier, J. (Jan); Hunfeld, J.A.M. (Joke)
    In:Human Reproduction, 22(9), 2554 - 2558. ISSN 0268-1161.

    Samenvatting:

    Background: Failure of IVF treatment after a number of cycles can be devastating for couples. Although mild IVF strategies reduce the psychological burden of treatment, failure may cause feelings of regret that a more aggressive approach, including the transfer of two embryos, was not employed. In t

  • Predictors of low response to mild ovarian stimulation initiated on cycle day 5 for IVF (2007)

    Auteurs:Verberg, M.F.G.; Eijkemans, M.J.C. (René); Macklon, N.S. (Nick); Heijnen, E.M.; Fauser, B.C.J.M. (Bart); Broekmans, F.J.M. (Frank)
    In:Human Reproduction, 22(7), 1919 - 1924. ISSN 0268-1161.

    Samenvatting:

    Background: Milder stimulation protocols are being developed to minimize adverse effects of ovarian stimulation in in vitro fertilization (IVF) programs. A drawback is the possibility of an increased rate of insufficient ovarian response. This study aimed to develop a prognostic model for the predic

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