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Prof.dr. F.G. Grosveld Persoon

Prof.dr. F.G. Grosveld

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  • Enhancers and silencers: An integrated and simple model for their function (2012)Open access

    Auteurs:Kolovos, P.; Knoch, T.A.; Grosveld, F.G.; Cook, P.R.; Papantonis, A.; Erasmus MC: University Medical Center Rotterdam
    In:Epigenetics & Chromatin, 5(1). ISSN 1756-8935.

    Samenvatting:

    Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share specific properties. Herein we discuss some examples and a parsimonious model for their function

  • A role for PML in innate immunity (2011)

    Auteurs:Lunardi, A. (Andrea); Gaboli, M. (Mirella); Giorgio, M. (Marco); Rivi, R. (Roberta); Bygrave, A. (Anne); Drabek, D.D. (Dubravka); Dzierzak, E.A. (Elaine); Fagioli, M. (Marta); Salmena, L. (Leonardo); Antoniou, M. (Michael); Botto, M. (Marina); Cordon-Cardo, C. (Carlos); Luzzatto, L. (Lucio); Pelicci, P.G.; Grosveld, F.G. (Frank); Pandolfi, P.P.
    In:Genes & Cancer, 2(1), 10 - 19. ISSN 1947-6019.

    Samenvatting:

    The promyelocytic leukemia gene (PML) of acute promyelocytic leukemia is an established tumor suppressor gene with critical functions in growth suppression, induction of apoptosis, and cellular senescence. Interestingly, although less studied, PML seems to play a key role also in immune response to

  • Approaching the internalization challenge of grid technologies into e-society by e-human "grid" ecology (2010)Open access

    Auteurs:Knoch, T.A. (Tobias); Baumgärtner, V. (Volkmar); Grosveld, F.G. (Frank); Egger, K.E. (Kurt)
    In:Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 6296 LNCS, 116 - 128. ISSN 0302-9743.

    Samenvatting:

    The amount of information is growing exponentially with ever-new technologies emerging and is believed to be always at the limit. In contrast, huge resources are obviously available, which are underused in the IT sector, similar as e.g. in the renewable energy sector. This is especially for grid wit

  • CTCF regulates the local epigenetic state of ribosomal DNA repeats (2010)Open access

    Auteurs:Nobelen, van de S. (Suzanne); Rosa-Garrido, M. (Manuel); Leers, J. (Joerg); Heath, H. (Helen); Soochit, W. (Widia); Joosen, L. (Linda); Jonkers, I. (Iris); Demmers, J.A. (Jeroen); Reijden, van der M. (Michael); Torrano, V. (Veránica); Grosveld, F.G. (Frank); Delgado, M.D. (Dolores); Renkawitz, R. (Rainer); Galjart, N.J. (Niels); Sleutels, F. (Frank)
    In:Epigenetics & Chromatin, 3(1). ISSN 1756-8935.

    Samenvatting:

    Background: CCCTC binding factor (CTCF) is a highly conserved zinc finger protein, which is involved in chromatin organization, local histone modifications, and RNA polymerase II-mediated gene transcription. CTCF may act by binding tightly to DNA and recruiting other proteins to mediate its various

  • The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons (2010)

    Auteurs:Tsarovina, K. (Konstantina); Reiff, T. (Tobias); Stubbusch, J. (Jutta); Kurek, D. (Dorota); Grosveld, F.G. (Frank); Parlato, R. (Rosanna); Schütz, G. (Günther); Rohrer, H. (Hermann)
    In:The Journal of Neuroscience, 30(32), 10833 - 10843. ISSN 0270-6474.

    Samenvatting:

    The transcription factor Gata3 is essential for the development of sympathetic neurons and adrenal chromaffin cells. As Gata3 expression is maintained up to the adult stage, we addressed its function in differentiated sympathoadrenal cells at embryonic and adult stages by conditional Gata3 eliminati

  • Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin (2010)

    Auteurs:Borg, J. (Joseph); Papadopoulos, P. (Petros); Georgitsi, M. (Marianthi); Gutiérrez, L. (Laura); Grech, G. (Godfrey); Fanis, P. (Pavlos); Phylactides, M. (Marios); Verkerk, J.H.M. (Annemieke); Spek, van der P.J. (Peter); Scerri, C.A. (Christian); Cassar, W. (Wilhelmina); Galdies, R. (Ruth); IJcken, van W.F.J. (Wilfred); Özgür, Z. (Zeliha); Gillemans, N. (Nynke); Hou, J. (Jun); Bugeja, M. (Marisa); Grosveld, F.G. (Frank); Lindern, von M.M. (Marieke); Felice, A.E. (Alex); Patrinos, G.P. (George); Philipsen, S. (Sjaak)
    In:Nature Genetics. ISSN 1061-4036.

    Samenvatting:

    Hereditary persistence of fetal hemoglobin (HPFH) is characterized by persistent high levels of fetal hemoglobin (HbF) in adults. Several contributory factors, both genetic and environmental, have been identified but others remain elusive. HPFH was found in 10 of 27 members from a Maltese family. We

  • Visualization, analysis, and design of COMBO-FISH probes in the grid-based GLOBE 3D genome platform (2010)Open access

    Auteurs:Kepper, F.N. (Nick); Schmitt, E. (Eberhard); Lesnussa, M. (Michael); Weiland, Y. (Yanina); Eussen, B.H.J. (Bert); Grosveld, F.G. (Frank); Hausmann, M. (Michael); Knoch, T.A. (Tobias)
    In:Studies in Health Technology and Informatics, 159, 171 - 180. ISSN 0926-9630.

    Samenvatting:

    The genome architecture in cell nuclei plays an important role in modern microscopy for the monitoring of medical diagnosis and therapy since changes of function and dynamics of genes are interlinked with changing geometrical parameters. The planning of corresponding diagnostic experiments and their

  • Parallel high-performance grid computing: Capabilities and opportunities of a novel demanding service and business class allowing highest resource efficiency (2010)Open access

    Auteurs:Kepper, F.N. (Nick); Ettig, R. (Ramona); Dickmann, F. (Frank); Stehr, R. (Rene); Grosveld, F.G. (Frank); Wedemann, G. (Gero); Knoch, T.A. (Tobias)
    In:Studies in Health Technology and Informatics, 159, 264 - 271. ISSN 0926-9630.

    Samenvatting:

    Especially in the life-science and the health-care sectors the huge IT requirements are imminent due to the large and complex systems to be analysed and simulated. Grid infrastructures play here a rapidly increasing role for research, diagnostics, and treatment, since they provide the necessary larg

  • The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation (2010)

    Auteurs:Soler, E. (Eric); Andrieu-Soler, C. (Charlotte); Boer, de E. (Ernie); Bryne, J.C.; Thongjuea, S. (Supat); Stadhouders, R. (Ralph); Palstra, R.J.T.S.; Stevens, M. (Martijn); Kockx, C. (Christel); IJcken, van W.F.J. (Wilfred); Hou, J. (Jun); Steinhoff, C. (Christine); Rijkers, E.J.; Lenhard, B. (Boris); Grosveld, F.G. (Frank)
    In:Genes & Development, 24(3), 277 - 289. ISSN 0890-9369.

    Samenvatting:

    One of the complexes formed by the hematopoietic transcription factor Gata1 is a complex with the Ldb1 (LIM domain-binding protein 1) and Tal1 proteins. It is known to be important for the development and differentiation of the erythroid cell lineage and is thought to be implicated in long-range int

  • Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases (2010)

    Auteurs:Dijk, van T.B. (Thamar); Gillemans, N. (Nynke); Stein, C. (Claudia); Fanis, P. (Pavlos); Demmers, J.A. (Jeroen); Corput, van de M. (Mariëtte); Essers, J. (Jeroen); Grosveld, F.G. (Frank); Bauer, U.M.; Philipsen, S. (Sjaak)
    In:Molecular and Cellular Biology, 30(1), 260 - 272. ISSN 0270-7306.

    Samenvatting:

    We describe the isolation and characterization of Friend of Prmt1 (Fop), a novel chromatin target of protein arginine methyltransferases. Human Fop is encoded by C1orf77, a gene of previously unknown function. We show that Fop is tightly associated with chromatin, and that it is modified by both asy

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