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Prof.dr. W.M. de Vos Persoon

Prof.dr. W.M. de Vos

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  • Microbiota conservation and BMI signatures in adult monozygotic twins (2013)

    Auteurs:Tims, S.; Derom, C.; Jonkers, D.M.A.E.; Vlietinck, R.; Saris, W.H.; Kleerebezem, M.; Vos, de W.M.; Zoetendal, E.G.
    In:ISME Journal, 7, 707 - 717. ISSN 1751-7362.

    Samenvatting:

    The human gastrointestinal (GI) tract microbiota acts like a virtual organ and is suggested to be of great importance in human energy balance and weight control. This study included 40 monozygotic (MZ) twin pairs to investigate the influence of the human genotype on GI microbiota structure as well a

  • Comparative Genomic and Functional Analysis of Lactobacillus casei and Lactobacillus rhamnosus Strains Marketed as Probiotics (2013)

    Auteurs:Douillard, F.P.; Ribbera, A.; Järvinen, H.M.; Kant, R.; Pietilä, T.E.; Randazzo, C.L.; Paulin, L.; Laine, P.K.; Caggia, C.; Ossowski, von I.; Reunanen, J.; Satokari, R.; Salminen, S.; Palva, A.; Vos, de W.M.
    In:Applied and Enviromental Microbiology, 79(6), 1923 - 1933. ISSN 0099-2240.

    Samenvatting:

    Four Lactobacillus strains were isolated from marketed probiotic products, including L. rhamnosus strains from Vifit (Friesland Campina) and Idoform (Ferrosan) and L. casei strains from Actimel (Danone) and Yakult (Yakult Honsa Co.). Their genomes and phenotypes were characterized and compared in de

  • Phylogenetic Analysis of Dysbiosis in Ulcerative Colitis During Remission (2013)

    Auteurs:Rajilic-Stojanovic, M.; Shanahan, F.; Guarner, F.; Vos, de W.M.
    In:Inflammatory Bowel Diseases, 19(3), 481 - 488. ISSN 1078-0998.

    Samenvatting:

    BACKGROUND:: Presence of intestinal microbes is a prerequisite for the development of ulcerative colitis (UC), although deviation of the normal intestinal microbiota composition, dysbiosis, is presumably implicated in the etiology of UC. METHODS:: The fecal microbiota of 30 UC samples obtained from

  • Towards metagenome-scale models for industrial applications-the case of Lactic Acid Bacteria (2013)

    Auteurs:Branco Dos Santos, F.; Vos, de W.M.; Teusink, B.
    In:Current Opinion in Biotechnology, 24(2), 200 - 206. ISSN 0958-1669.

    Samenvatting:

    We review the uses and limitations of modelling approaches that are in use in the field of Lactic Acid Bacteria (LAB). We describe recent developments in model construction and computational methods, starting from application of such models to monocultures. However, since most applications in food b

  • Microarray analysis reveals marked intestinal microbiota aberrancy in infants having eczema compared to healthy children in at-risk for atopic disease (2013)Open access

    Auteurs:Nylund, L.; Satokari, R.; Nikkilä, J.; Rajilic-Stojanovic, M.; Kalliomäki, M.; Isolauri, E.; Salminen, S.; Vos, de W.M.
    In:BMC Microbiology, 13(12). ISSN 1471-2180.

    Samenvatting:

    BACKGROUND: Deviations in composition and diversity of intestinal microbiota in infancy have been associated with both the development and recurrence of atopic eczema. Thus, we decided to use a deep and global microarray-based method to characterize the diversity and temporal changes of the intesti

  • Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile (2013)

    Auteurs:Nood, van E.; Vrieze, A.; Nieuwdorp, M.; Fuentes Enriquez de Salamanca, S.; Zoetendal, E.G.; Vos, de W.M.; Visser, C.E.; Kuijper, E.J.; Bartelsman, J.F.; Tijssen, J.G.; Speelman, P.; Dijkgraaf, M.G.; Keller, J.J.
    In:New England Journal of Medicine, 368(5), 407 - 415. ISSN 0028-4793.

    Samenvatting:

    Background Recurrent Clostridium difficile infection is difficult to treat, and failure rates for antibiotic therapy are high. We studied the effect of duodenal infusion of donor feces in patients with recurrent C. difficile infection. Methods We randomly assigned patients to receive one of three th

  • Contribution of the Intestinal Microbiota to Human Health: From Birth to 100 Years of Age (2013)

    Auteurs:Cheng, J.; Palva, A.M.; Vos, de W.M.; Satokari, R.
    In:Current Topics in Microbiology and Immunology, 358, 323 - 346. ISSN 0070-217x.

    Samenvatting:

    Our intestinal tract is colonized since birth by multiple microbial species that show a characteristic succession in time. Notably the establishment of the microbiota in early life is important as it appears to impact later health. While apparently stable in healthy adults, the intestinal microbiota

  • Long-term monitoring of the human intestinal microbiota composition (2013)

    Auteurs:Rajilic-Stojanovic, M.; Heilig, G.H.J.; Tims, S.; Zoetendal, E.G.; Vos, de W.M.
    In:Applied and Enviromental Microbiology, 15(4), 1146 - 1159. ISSN 0099-2240.

    Samenvatting:

    The microbiota that colonizes the human intestinal tract is complex and its structure is specific for each of us. In this study we expand the knowledge about the stability of the subject-specific microbiota and show that this ecosystem is stable in short-term intervals (< 1 year) but also during lon

  • Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model (2013)

    Auteurs:Abbeele, van den P.; Belzer, C.; Goossens, M.; Kleerebezem, M.; Vos, de W.M.; Thas, O.; Weirdt, de R.; Kerckhoffs, D.M.F.J.; Wiele, van der T.
    In:ISME Journal, 7, 949 - 961. ISSN 1751-7362.

    Samenvatting:

    The human gut is colonized by a complex microbiota with multiple benefits. Although the surface-attached, mucosal microbiota has a unique composition and potential to influence human health, it remains difficult to study in vivo. Therefore, we performed an in-depth microbial characterization (human

  • Intestinal Microbiota of Infants With Colic: Development and Specific Signatures (2013)

    Auteurs:Weerth, de C.; Fuentes Enriquez de Salamanca, S.; Puylaert, P.G.B.; Vos, de W.M.
    In:Pediatrics, 131(2), e550 - e558. ISSN 0031-4005.

    Samenvatting:

    OBJECTIVES:To provide a comprehensive analysis of the fecal microbiota in infants with colic, as compared with control infants, during their first 100 days of life.METHODS:Microbial DNA of >200 samples from 12 infants with colic and 12 age-matched control infants was extracted and hybridized to a ph

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