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Prof.dr. J. Schalkwijk Person

Prof.dr. J. Schalkwijk

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  • Wenn Stress unter die Haut geht : Cortisol und Stress in Psoriasis (2010)

    Authors:Evers, A.W.M.; Verhoeven, E.W.M.; Kraaimaat, F.W.; Jong, E.M.G.J. de; Brouwer, S.J.M. de; Schalkwijk, J.; Sweep, C.G.J.; Kerkhof, P.C.M. van de
    In:Haut, 21, 278 - 279. ISSN 0938-2216.

  • Keratinocytes drive melanoma invasion in a reconstructed skin model. (2010)

    Authors:Kilsdonk, J.W.J. van; Bergers, M.; Kempen, L.C.L.T. van; Schalkwijk, J.; Swart, G.W.
    In:Melanoma Research, 20, 372 - 380. ISSN 0960-8931.

    Abstract:

    Melanoma progression is a multistep progression from a common melanocytic nevus through the radial growth phase, the invasive vertical growth phase finally leading to metastatic spread into distant organs. Migration and invasion of tumor cells requires secretion of proteases to facilitate remodeling

  • Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis. (2010)

    Authors:Bergboer, J.G.M.; Zeeuwen, P.L.J.M.; Irvine, A.D.; Weidinger, S.; Giardina, E.; Novelli, G.; Heijer, M. den; Rodriguez, E.; Illig, T.; Riveira-Munoz, E.; Campbell, L.E.; Tyson, J.; Dannhauser, E.N.; O'Regan, G.M.; Galli, E.; Klopp, N.; Koppelman, G.H.; Novak, N.; Estivill, X.; McLean, W.H.I.; Postma, D.S.; Armour, J.A.; Schalkwijk, J.
    In:Journal of Investigative Dermatology, 130, 2057 - 2061. ISSN 0022-202x.

    Abstract:

    Atopic dermatitis (AD) and psoriasis are common skin diseases characterized by cutaneous inflammation and disturbed epidermal differentiation. Genome-wide analyses have shown overlapping susceptibility loci, such as the epidermal differentiation complex on chromosome 1q21. Recently, a deletion on 1q

  • How stress gets under the skin: cortisol and stress reactivity in psoriasis. (2010)

    Authors:Evers, A.W.M.; Verhoeven, E.W.M.; Kraaimaat, F.W.; Jong, E.M.G.J. de; Brouwer, S.J.M. de; Schalkwijk, J.; Sweep, F.C.; Kerkhof, P.C.M. van de
    In:British Journal of Dermatology, 163, 986 - 991. ISSN 0007-0963.

    Abstract:

    BACKGROUND: Psychological stressors might contribute to the severity of chronic inflammatory diseases such as psoriasis by dysregulating hypothalamic-pituitary-adrenal (HPA) axis activity. OBJECTIVES: To evaluate the role of cortisol, a key component of the HPA axis, in reaction to psychological str

  • The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea. (2010)

    Authors:Zeeuwen, P.L.J.M.; Vlijmen-Willems, I.M.J.J. van; Cheng, T.; Rodijk-Olthuis, D.; Hitomi, K.; Hara-Nishimura, I.; John, S.; Smyth, N.; Reinheckel, T.; Hendriks, W.J.A.J.; Schalkwijk, J.
    In:FASEB Journal, 24, 3744 - 3755. ISSN 0892-6638.

    Abstract:

    Cystatin M/E (CST6) is a nonredundant, epithelium-specific protease inhibitor with a presumed role in epidermal differentiation and tumor suppression. We have previously reported that cystatin M/E deficiency in Cst6(-/-) mice causes neonatal lethality because of excessive transepidermal water loss.

  • Tenascin-X deficiency and Ehlers-Danlos syndrome: a case report and review of the literature. (2010)

    Authors:O'Connell, M.; Burrows, N.P.; Vlijmen-Willems, I.M.J.J. van; Clark, S.M.; Schalkwijk, J.
    In:British Journal of Dermatology, 163, 1340 - 1345. ISSN 0007-0963.

    Abstract:

    Tenascin-X is a large extracellular matrix glycoprotein that is widely distributed within connective tissues and is associated with an autosomal recessive type of Ehlers-Danlos syndrome (EDS). Tenascin-X represents the first EDS susceptibility gene that does not code for a fibrillar collagen or coll

  • Molecular diagnostics of psoriasis, atopic dermatitis, allergic contact dermatitis and irritant contact dermatitis. (2010)

    Authors:Kamsteeg, M.; Jansen, P.A.M.; Vlijmen-Willems, I.M.J.J. van; Erp, P.E.J. van; Rodijk-Olthuis, D.; Valk, P.G.M. van der; Feuth, T.; Zeeuwen, P.L.J.M.; Schalkwijk, J.
    In:British Journal of Dermatology, 162, 568 - 578. ISSN 0007-0963.

    Abstract:

    BACKGROUND: Microarray studies on the epidermal transcriptome in psoriasis and atopic dermatitis (AD) have revealed genes with disease-specific expression in keratinocytes of lesional epidermis. These genes are possible candidates for disease-specific pathogenetic changes, but could also provide a t

  • A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. (2010)

    Authors:Strange, A.; Capon, F.; Spencer, C.C.; Knight, J.; Weale, M.E.; Allen, M.H.; Barton, A.; Band, G.; Bellenguez, C.; Bergboer, J.G.M.; Blackwell, J.M.; Bramon, E.; Bumpstead, S.J.; Casas, J.P.; Cork, M.J.; Corvin, A.; Deloukas, P.; Dilthey, A.; Duncanson, A.; Edkins, S.; Estivill, X.; Fitzgerald, O.; Freeman, C.; Giardina, E.; Gray, E.; Hofer, A.; Huffmeier, U.; Hunt, S.E.; Irvine, A.D.; Jankowski, J.; Kirby, B.; Langford, C.; Lascorz, J.; Leman, J.; Leslie, S.; Mallbris, L.; Markus, H.S.; Mathew, C.G.; McLean, W.H.I.; McManus, R.; Mossner, R.; Moutsianas, L.; Naluai, A.T.; Nestle, F.O.; Novelli, G.; Onoufriadis, A.; Palmer, C.N.; Perricone, C.; Pirinen, M.; Plomin, R.; Potter, S.C.; Pujol, R.M.; Rautanen, A.; Riveira-Munoz, E.; Ryan, A.W.; Salmhofer, W.; Samuelsson, L.; Sawcer, S.J.; Schalkwijk, J.; Smith, C.H.; Stahle, M.; Su, Z.; Tazi-Ahnini, R.; Traupe, H.; Viswanathan, A.C.; Warren, R.B.; Weger, W.; Wolk, K.; Wood, N.; Worthington, J.; Young, H.S.; Zeeuwen, P.L.J.M.; Hayday, A.; Burden, A.D.; Griffiths, C.E.; Kere, J.; Reis, A.; McVean, G.; Evans, D.M.; Brown, M.A.; Barker, J.N.; Peltonen, L.; Donnelly, P.; Trembath, R.C.
    In:Nature Genetics, 42, 985 - 990. ISSN 1061-4036.

    Abstract:

    To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions (

  • A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis. (2010)

    Authors:Koning, H.D. de; Rodijk-Olthuis, D.; Vlijmen-Willems, I.M.J.J. van; Joosten, L.A.B.; Netea, M.G.; Schalkwijk, J.; Zeeuwen, P.L.J.M.
    In:Journal of Investigative Dermatology, 130, 2611 - 2620. ISSN 0022-202x.

    Abstract:

    Human epidermis plays an important role in host defense by acting as a physical barrier and signaling interface between the environment and the immune system. Pattern recognition receptors (PRRs) are crucial to maintain homeostasis and provide protection during infection, but are also causally invol

  • Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors. (2010)

    Authors:Huffmeier, U.; Bergboer, J.G.M.; Becker, T.; Armour, J.A.; Traupe, H.; Estivill, X.; Riveira-Munoz, E.; Mossner, R.; Reich, K.; Kurrat, W.; Wienker, T.F.; Schalkwijk, J.; Zeeuwen, P.L.J.M.; Reis, A.
    In:Journal of Investigative Dermatology, 130, 979 - 984. ISSN 0022-202x.

    Abstract:

    Recently, a deletion of two late cornified envelope (LCE) genes within the epidermal differentiation complex on chromosome 1 was shown to be overrepresented in 1,426 psoriasis vulgaris (PsV) patients of European ancestry. In this study, we report a confirmation of this finding in 1,354 PsV patients

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