Prof.dr. J. Schalkwijk

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Radboud Universiteit Nijmegen (95)

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A proteomics platform combining depletion, multi-lectin affinity chromatography (M-LAC), and isoelectric focusing to study the breast cancer proteome (2011)

Auteurs: Zeng, Z.; Hincapie, M.; Pitteri, S.J.; Hanash, S.; Schalkwijk, J.; Hogan, J.M.; Wang, H.; Hancock, W.S.
In: Analytical Chemistry, 83, 4845 - 4854. ISSN 0003-2700.

Samenvatting:
The discovery of breast cancer associated plasma/serum biomarkers is important for early diagnosis, disease mechanism elucidation, and determination of treatment strategy for the disease. In this study of serum samples, a multidimensional fractionation platform combined with mass spectrometric analy

Auteurs:	Zeng, Z.; Hincapie, M.; Pitteri, S.J.; Hanash, S.; Schalkwijk, J.; Hogan, J.M.; Wang, H.; Hancock, W.S.
In:	Analytical Chemistry, 83, 4845 - 4854. ISSN 0003-2700.

An overview of methods for the in vivo evaluation of tissue-engineered skin constructs (2011)

Auteurs:	Lammers, G.; Verhaegen, P.D.; Ulrich, M.M.; Schalkwijk, J.; Middelkoop, E.; Weiland, D.; Nillesen, S.T.M.; Kuppevelt, A.H.M.S.M. van; Daamen, W.F.
In:	Tissue Engineering Part B Reviews, 17, 33 - 55. ISSN 1937-3368.

Samenvatting:

Cutaneous wounding often leads to contraction and scarring, which may result in a range of functional, cosmetic, and psychological complications. Tissue-engineered skin substitutes are being developed to enhance restoration of the skin and improve the quality of wound healing. The aim of this review

Mild muscular features in tenascin-x knockout mice, a model of ehlers-danlos syndrome (2011)

Auteurs:	Voermans, N.C.; Verrijp, K.; Eshuis, L.; Balemans, M.C.M.; Egging, D.F.; Sterrenburg, E.; Rooij, I.A. van; Laak, J.A.W.M. van der; Schalkwijk, J.; Maarel, S. van der; Lammens, M.M.Y.; Engelen, B.G. van
In:	Connective Tissue Research, 52, 422 - 432. ISSN 0300-8207.

Samenvatting:

INTRODUCTION: Tenascin-X (TNX) is an extracellular matrix (ECM) glycoprotein, the absence of which in humans leads to a recessive form of Ehlers-Danlos syndrome (EDS), a group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility

Accuracy and differential bias in copy number measurement of CCL3L1 in association studies with three auto-immune disorders (2011)

Auteurs: Carpenter, D.; Walker, S.; Prescott, N.; Schalkwijk, J.; Armour, J.A.
In: BMC Genomics, 12, 418 - 418. ISSN 1471-2164.

Samenvatting:
BACKGROUND: Copy number variation (CNV) contributes to the variation observed between individuals and can influence human disease progression, but the accurate measurement of individual copy numbers is technically challenging. In the work presented here we describe a modification to a previously des

Auteurs:	Carpenter, D.; Walker, S.; Prescott, N.; Schalkwijk, J.; Armour, J.A.
In:	BMC Genomics, 12, 418 - 418. ISSN 1471-2164.

Design and in vivo evaluation of a molecularly defined acellular skin construct: reduction of early contraction and increase in early blood vessel formation (2011)

Auteurs:	Nillesen, S.T.M.; Lammers, G.; Wismans, R.; Ulrich, M.M.; Middelkoop, E.; Spauwen, P.H.M.; Faraj, K.A.; Schalkwijk, J.; Daamen, W.F.; Kuppevelt, A.H.M.S.M. van
In:	Acta Biomaterialia, 7, 1063 - 1071. ISSN 1742-7061.

Samenvatting:

Skin substitutes are of great benefit in the treatment of patients with full thickness wounds, but there is a need for improvement with respect to wound closure with minimal contraction, early vascularisation, and elastin formation. In this study we designed and developed an acellular double-layered

Epidermal expression of host response genes upon skin barrier disruption in normal skin and uninvolved skin of psoriasis and atopic dermatitis patients (2011)

Auteurs:	de Koning, H.D.; Kamsteeg, M.; Rodijk-Olthuis, D.; Vlijmen-Willems, I.M.J.J. van; Erp, P.E.J. van; Schalkwijk, J.; Zeeuwen, P.L.J.M.
In:	Journal of Investigative Dermatology, 131, 263 - 266. ISSN 0022-202x.

Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6 (2011)

Auteurs:	Riveira-Munoz, E.; He, S.M.; Escaramis, G.; Stuart, P.E.; Huffmeier, U.; Lee, C.; Kirby, B.; Oka, A.; Giardina, E.; Liao, W.; Bergboer, J.G.M.; Kainu, K.; Cid, R. de; Munkhbat, B.; Zeeuwen, P.L.J.M.; Armour, J.A.; Poon, A.; Mabuchi, T.; Ozawa, A.; Zawirska, A.; Burden, A.D.; Barker, J.N.; Capon, F.; Traupe, H.; Sun, L.D.; Cui, Y.; Yin, X.Y.; Chen, G.; Lim, H.W.; Nair, R.P.; Voorhees, J.J.; Tejasvi, T.; Pujol, R.; Munkhtuvshin, N.; Fischer, J.; Kere, J.; Schalkwijk, J.; Bowcock, A.; Kwok, P.Y.; Novelli, G.; Inoko, H.; Ryan, A.W.; Trembath, R.C.; Reis, A.; Zhang, X.J.; Elder, J.T.; Estivill, X.
In:	Journal of Investigative Dermatology, 131, 1105 - 1109. ISSN 0022-202x.

Auteurs:

Riveira-Munoz, E.; He, S.M.; Escaramis, G.; Stuart, P.E.; Huffmeier, U.; Lee, C.; Kirby, B.; Oka, A.; Giardina, E.; Liao, W.; Bergboer, J.G.M.; Kainu, K.; Cid, R. de; Munkhbat, B.; Zeeuwen, P.L.J.M.; Armour, J.A.; Poon, A.; Mabuchi, T.; Ozawa, A.; Zawirska, A.; Burden, A.D.; Barker, J.N.; Capon, F.; Traupe, H.; Sun, L.D.; Cui, Y.; Yin, X.Y.; Chen, G.; Lim, H.W.; Nair, R.P.; Voorhees, J.J.; Tejasvi, T.; Pujol, R.; Munkhtuvshin, N.; Fischer, J.; Kere, J.; Schalkwijk, J.; Bowcock, A.; Kwok, P.Y.; Novelli, G.; Inoko, H.; Ryan, A.W.; Trembath, R.C.; Reis, A.; Zhang, X.J.; Elder, J.T.; Estivill, X.

In:

Journal of Investigative Dermatology, 131, 1105 - 1109. ISSN 0022-202x.

Samenvatting:

A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that

Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups (2011)

Auteurs:	Bergboer, J.G.M.; Tjabringa, G.S.; Kamsteeg, M.; Vlijmen-Willems, I.M. van; Rodijk-Olthuis, D.; Jansen, P.A.M.; Thuret, J.Y.; Narita, M.; Ishida-Yamamoto, A.; Zeeuwen, P.L.J.M.; Schalkwijk, J.
In:	American Journal of Pathology, 178, 1470 - 1477. ISSN 0002-9440.

Samenvatting:

Deletion of the late cornified envelope (LCE) genes LCE3B and LCE3C has recently been identified as a risk factor for psoriasis. Expression of 16 LCE genes of LCE groups 1, 2, 3, 5, and 6 was examined in vivo and in vitro. Quantitative PCR demonstrated that moderate to high LCE expression was largel

Successful canakinumab treatment identifies IL-1beta as a pivotal mediator in Schnitzler syndrome. (2011)

Auteurs: Koning, H.D. de; Schalkwijk, J.; Meer, J.W.M. van der; Simon, A.
In: Journal of Allergy and Clinical Immunology, 128, 1352 - 1354. ISSN 0091-6749.

Auteurs:	Koning, H.D. de; Schalkwijk, J.; Meer, J.W.M. van der; Simon, A.
In:	Journal of Allergy and Clinical Immunology, 128, 1352 - 1354. ISSN 0091-6749.

Type 2 helper T-cell cytokines induce morphologic and molecular characteristics of atopic dermatitis in human skin equivalent (2011)

Auteurs:	Kamsteeg, M.; Bergers, M.; Boer, R.T. de; Zeeuwen, P.L.J.M.; Hato, S.V.; Schalkwijk, J.; Tjabringa, G.S.
In:	American Journal of Pathology, 178, 2091 - 2099. ISSN 0002-9440.

Samenvatting:

Both the immune system and the epidermis likely have an important role in the pathogenesis of atopic dermatitis (AD). The objective of the present study was to develop a human skin equivalent model exhibiting morphologic and molecular characteristics of AD in a controlled manner. Skin equivalents ge

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