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Prof.dr. D. Tibboel

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  • Etiology of esophageal atresia and tracheoesophageal fistula: "Mind the gap" (2010)

    Auteurs:Jong, de E.M. (Elisabeth); Felix, J.F. (Janine); Klein, de J.E.M.M. (Annelies); Tibboel, D. (Dick)
    In:Current Gastroenterology Reports (Print), 12(3), 215 - 222. ISSN 1522-8037.

    Samenvatting:

    Esophageal atresia and tracheoesophageal fistula (EA/TEF) are major congenitalmalformations affecting 1:3500 live births. Current research efforts are focused on understanding the etiology of these defects. We describe well-known animal models, human syndromes, and associations involving EA/TEF, ind

  • Mortality in very long-stay pediatric intensive care unit patients and incidence of withdrawal of treatment (2010)Open access

    Auteurs:Naghib, S. (Sara); Starre, van der C. (Cynthia); Gischler, S.J. (Saskia); Joosten, K.F.M. (Koen); Tibboel, D. (Dick)
    In:Intensive Care Medicine, 36(1), 131 - 136. ISSN 0342-4642.

    Samenvatting:

    Background: The mortality for children with prolonged stay in pediatric intensive care units (PICU) is much higher than overall mortality. The incidence of withdrawal or limitation of therapy in this group is unknown. Purpose: To assess mortality and characteristics of children admitted for ≥28 days

  • The use of the behavioral pain scale to assess pain in conscious sedated patients (2010)

    Auteurs:Ahlers, S.J.G.M. (Sabine); Veen, van der A.M. (Aletta); Dijk, van M. (Monique); Tibboel, D. (Dick); Knibbe, C.A.
    In:Anesthesia and Analgesia, 110(1), 127 - 133. ISSN 0003-2999.

    Samenvatting:

    Background: Assessing pain in mechanically ventilated critically ill patients is a great challenge. There is a need for an adequate pain measurement tool for use in conscious sedated patients because of their questionable communicative abilities. In this study, we evaluated the use of the Behavioral

  • Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors (2009)

    Auteurs:Gontan, C. (Cristina); Guttler, T. (Thomas); Engelen, E. (Erik); Demmers, J.A. (Jeroen); Fornerod, M.W.J. (Maarten); Grosveld, F.G. (Frank); Tibboel, D. (Dick); Görlich, D. (Dirk); Poot, R.A. (Raymond); Rottier, R. (Robbert)
    In:The Journal of Cell Biology, 185(1), 27 - 34. ISSN 0021-9525.

    Samenvatting:

    SRY and other Sox-type transcription factors are important developmental regulators with various implications in human disease. In this study, we identified Exp4 (exportin 4) as an interaction partner of Sox2 in mouse embryonic stem cells and neural progenitors. We show that, besides its established

  • Motor performance in five-year-old extracorporeal membrane oxygenation survivors: A population-based study (2009)Open access

    Auteurs:Nijhuis-van der Sanden, M.W.G. (Maria); Cammen-van Zijp, van der M.H.M. (Monica); Janssen, A.J.W.M. (Anjo); Reuser, J.J.C.M. (Jolanda); Mazer, P. (Petronella); Heijst, van A.F.J. (Arno); Gischler, S.J. (Saskia); Tibboel, D. (Dick); Kollee, L.A.
    In:Critical Care (Print), 13(2). ISSN 1364-8535.

    Samenvatting:

    Introduction: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a cardio-pulmonary bypass technique to provide life support in acute reversible cardio-respiratory failure when conventional management is not successful. Most neonates receiving ECMO suffer from meconium aspiration syndrom

  • The Rotterdam Elderly Pain Observation Scale (REPOS): A New Behavioral Pain Scale for Non-Communicative Adults and Cognitively Impaired Elderly Persons (2009)Open access

    Auteurs:Herk, van R. (Rhodee); Dijk, van M. (Monique); Tibboel, D. (Dick); Baar, F.P.M. (Frans); Wit, de R. (Rianne)
    In:Journal of Pain Management, 1(4), 367 - 378. ISSN 1939-5914.

    Samenvatting:

    Abstract: Several observation scales have been developed to measure pain in elderly persons with cognitive impairments. Most scales, however, do not provide cut-off scores for pain, and previous studies do not include data on non-verbal patients with diagnoses other than dementia. Objective: The de

  • Isolated or non-isolated duodenal obstruction: Perinatal outcome following prenatal or postnatal diagnosis (2008)

    Auteurs:Cohen-Overbeek, T.E. (Titia); Grijseels, E.W.M. (Els); Niemeijer, N.D.; Hop, W.C.J. (Wim); Wladimiroff, J.W. (Juriy); Tibboel, D. (Dick)
    In:Ultrasound in Obstetrics and Gynecology, 32(6), 784 - 792. ISSN 0960-7692.

    Samenvatting:

    Objectives To determine whether the pre- or postnatal diagnosis of either isolated or non-isolated duodenal obstruction (DO) is associated with different outcomes. Methods A single-center retrospective analysis was carried out of 91 cases diagnosed with a DO between January 1991 and June 2003. Data

  • Comparison of bispectral index and composite auditory evoked potential index for monitoring depth of hypnosis in children (2008)

    Auteurs:Oud-Alblas, van H.J.B.; Peters, J.W.B. (Jeroen); Leeuw, de T.G. (Tom); Tibboel, D. (Dick); Klein, J. (Jan); Weber, F. (Frank)
    In:Anesthesiology, 108(5), 851 - 857. ISSN 0003-3022.

    Samenvatting:

    BACKGROUND: In pediatric patients, the Bispectral Index (BIS), derived from the electroencephalogram, and the composite A-Line autoregressive index (cAAI), derived from auditory evoked potentials and the electroencephalogram, have been used as measurements of depth of hypnosis during anesthesia. The

  • Covariates of tramadol disposition in the first months of life (2008)

    Auteurs:Allegaert, K.; Anker, van den J.N. (John); Hoon, de J.N.; Schaik, van R.H.N. (Ron); Debeer, A. (Anne); Tibboel, D. (Dick); Naulaers, G.; Anderson, B.J.
    In:British Journal of Anaesthesia, 100(4), 525 - 532. ISSN 0007-0912.

    Samenvatting:

    Background. Data on contributors to between-individual variability in overall tramadol clearance and O-demethyl tramadol (M1) formation in preterm neonates and young infants are limited. Methods. A population pharmacokinetic analysis of tramadol and M1 was undertaken using non-linear mixed effects m

  • Comparison of different pain scoring systems in critically ill patients in a general ICU (2008)

    Auteurs:Ahlers, S.J.G.M. (Sabine); Gulik, van L. (Laura); Veen, van der A.M. (Aletta); Dongen, van H.P.A. (Hendricus); Bruins, P. (Peter); Belitser, S.V.; Boer, de A. (Anthonius); Tibboel, D. (Dick); Knibbe, C.A.
    In:Critical Care (Print), 12(1). ISSN 1364-8535.

    Samenvatting:

    Background: Pain in critically ill patients in the intensive care unit (ICU) is common. However, pain assessment in critically ill patients often is complicated because these patients are unable to communicate effectively. Therefore, we designed a study (a) to determine the inter-rater reliability o

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