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Prof.dr. R. Pieters

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  • Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia (2011)Open access

    Authors:Balgobind, B.V. (Brian); Hollink, I.H.I.M. (Iris); Arentsen-Peters, S.T.C.J.M. (Susan); Zimmermann, M. (Martin); Harbott, J. (Jochen); Beverloo, H.B. (Berna); Bergh, von A.R.M. (Anne); Cloos, J. (Jacqueline); Kaspers, G.J. (Gertjan); Haas, de V. (Valerie); Zemanová, Z. (Zuzana); Stary, J. (Jan); Cayuela, J.M. (Jean Michel); Baruchel, A. (André); Creutzig, U. (Ursula); Reinhardt, D. (Dirk); Pieters, R.A. (Rob); Michel Zwaan, C.; Heuvel-Eibrink, van den M.M. (Marry)
    In:Haematologica, 96(10), 1478 - 1487. ISSN 0390-6078.

    Abstract:

    Background Several studies of pediatric acute myeloid leukemia have described the various type-I or type- II aberrations and their relationship with clinical outcome. However, there has been no recent comprehensive overview of these genetic berrations in one large pediatric acute myeloid leukemia co

  • In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia (2011)

    Authors:Homminga, I. (Irene); Zwaan, C.M. (Christian Michel); Manz, C.Y. (Chantal); Parker, C. (Cynthia); Bantia, S. (Shanta); Smits, W.K.; Higginbotham, F. (Fiona); Pieters, R.A. (Rob); Meijerink, J.P.P. (Jules)
    In:Blood, 118(8), 2184 - 2190. ISSN 0006-4971.

    Abstract:

    Forodesine and nelarabine (the pro-drug of ara-G) are 2 nucleoside analogues with promising anti-leukemic activity. To better understand which pediatric patients might benefit from forodesine or nelarabine (ara-G) therapy, we investigated the in vitro sensitivity to these drugs in 96 diagnostic pedi

  • Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: Results of an international study (2011)

    Authors:Coenen, E.A. (Eva); Raimondi, S. (Susana); Harbott, J. (Jochen); Zimmermann, M. (Martin); Beverloo, H.B. (Berna); Chang, M. (Myron); Creutzig, U. (Ursula); Dworzak, M.N. (Michael); Forestier, E. (Erik); Gibson, B. (Brenda); Hasle, H. (Henrik); Harrison, C.J. (Christine); Heerema, N.A. (Nyla); Kaspers, G.J. (Gertjan); Leszl, A. (Anna); Litvinko, N. (Nathalia); Nigro, L.L. (Luca); Morimoto, A. (Akira); Perot, C. (Christine); Auvrignon, A. (Anne); Reinhardt, D. (Dirk); Rubnitz, J.E. (Jeffrey); Smith, F.O. (Franklin); Stary, J. (Jan); Stasevich, I. (Irina); Strehl, S. (Sabine); Taga, T. (Takashi); Tomizawa, D. (Daisuke); Webb, D. (David); Zemanová, Z. (Zuzana); Alonzo, T.A. (Todd); Pieters, R.A. (Rob); Zwaan, C.M. (Christian Michel); Heuvel-Eibrink, van den M.M. (Marry)
    In:Blood, 117(26), 7102 - 7111. ISSN 0006-4971.

    Abstract:

    We previously demonstrated that outcome of pediatric 11q23/MLL-rearranged AML depends on the translocation partner (TP). In this multicenter international study on 733 children with 11q23/MLL-rearranged AML, we further analyzed which additional cytogenetic aberrations (ACA) had prognostic significan

  • MicroRNA characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia (2011)Open access

    Authors:Schotte, D. (Diana); Menezes, de R.X. (Renee); Moqadam, F.A. (Farhad Akbari); Khankahdani, L.M. (Leila Mohammadi); Lange-Turenhout, E.A.M. (Ellen); Chen, C. (Caifu); Pieters, R.A. (Rob); Boer, den M.L. (Monique)
    In:Haematologica, 96(5), 703 - 711. ISSN 0390-6078.

    Abstract:

    Background MicroRNA regulate the activity of protein-coding genes including those involved in hematopoietic cancers. The aim of the current study was to explore which microRNA are unique for seven different subtypes of pediatric acute lymphoblastic leukemia. Design and Methods Expression levels of 3

  • Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia (2011)Open access

    Authors:Hollink, I.H.I.M. (Iris); Heuvel-Eibrink, van den M.M. (Marry); Arentsen-Peters, S.T.C.J.M. (Susan); Zimmermann, M. (Martin); Peeters, J. (Justine); Valk, P.J.M. (Peter); Balgobind, B.V. (Brian); Sonneveld, E. (Edwin); Kaspers, G.J. (Gertjan); Bont, de E.S.J.M. (Evelien); Trka, J.; Baruchel, A. (André); Creutzig, U. (Ursula); Pieters, R.A. (Rob); Reinhardt, D. (Dirk); Zwaan, C.M. (Christian Michel)
    In:Haematologica, 96(3), 384 - 392. ISSN 0390-6078.

    Abstract:

    Background Dysfunctioning of CCAAT/enhancer binding protein α (C/EBP α) in acute myeloid leukemia can be caused, amongst others, by mutations in the encoding gene (CEBPA) and by promoter hypermethylation. CEBPA-mutated acute myeloid leukemia is associated with a favorable outcome, but this may be re

  • Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia (2011)Open access

    Authors:Balgobind, B.V. (Brian); Heuvel-Eibrink, van den M.M. (Marry); Menezes, de R.X. (Renee); Reinhardt, D. (Dirk); Hollink, I.H.I.M. (Iris); Arentsen-Peters, S.T.C.J.M. (Susan); Wering, van E.R. (Elisabeth); Kaspers, G.J. (Gertjan); Cloos, J. (Jacqueline); Bont, de E.S.J.M. (Evelien); Cayuela, J.M. (Jean Michel); Baruchel, A. (André); Meyer, C. (Claus); Marschalek, R. (Rolf); Trka, J.; Stary, J. (Jan); Beverloo, H.B. (Berna); Pieters, R.A. (Rob); Zwaan, C.M. (Christian Michel); Boer, den M.L. (Monique)
    In:Haematologica, 96(2), 221 - 230. ISSN 0390-6078.

    Abstract:

    Background Pediatric acute myeloid leukemia is a heterogeneous disease characterized by non-random genetic aberrations related to outcome. The genetic subtype is currently detected by different diagnostic procedures which differ in success rate and/or specificity. Design and Methods We examined the

  • CD73 (5 '-nucleotidase) expression has no prognostic value in children with acute lymphoblastic leukemia (2011)

    Authors:Wieten, E.; Linden-Schrever, van der B.; Sonneveld, E.; Veerman, A.J.P.; Pieters, R.

  • Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale (2011)

    Authors:Stumpel, D.J.P.M.; Schotte, D.; Lange-Turenhout, E.; Schneider, P.; Seslija, L.; Xavier Menezes, de R.; Marquez, V.E.; Pieters, R.; Boer, den M.L.; Stam, R.W.

  • Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia (2011)Open access

    Authors:Balgobind, B.V.; Heuvel-Eibrink, van den M.; Xavier Menezes, de R.; Reinhardt, D; Hollink, I.H.I.M.; Arentsen-Peters, S.T.C.J.M.; Wering, van E.R.; Kaspers, G.J.L.; Cloos, J.; Bont, E.S.J.M. De; Cayuela, J.M.; Baruchel, A.; Meyer, C.; Marschalek, R.; Trka, J.; Stary, J; Beverloo, B.H.; Pieters, R.; Zwaan, C.M.; Boer, den M.L.

  • Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia (2011)Open access

    Authors:Balgobind, B.V.; Hollink, I.H.I.M.; Arentsen-Peters, S.T.C.J.M.; Zimmermann, M; Harbott, J; Beverloo, HB; Bergh, A.R.M. von; Cloos, J.; Kaspers, G.J.L.; Haas, de V.; Zemanova, Z.; Stary, J; Cayuela, J.M.; Baruchel, A.; Creutzig, U.; Reinhardt, D; Pieters, R.; Zwaan, C.M.; Heuvel-Eibrink, van den M.

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