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Prof.dr. F.R. Rosendaal Person

Prof.dr. F.R. Rosendaal

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  • Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design (2009)Open access

    Authors:Schie, van R.F.M. (Rianne); Wadelius, M. (Mia); Kamali, F. (Farhad); Daly, A.K. (Ann); Manolopoulos, V.G. (Vangelis); Boer, de A. (Anthonius); Barallon, R. (Rita); Verhoef, T.I. (Talitha); Kirchheiner, J. (Julia); Haschke-Becher, E. (Elisabeth); Briz, M. (Montserrat); Rosendaal, F.R. (Frits); Redekop, W.K. (Ken); Pirmohamed, M. (Munir); Maitland-van der Zee, A-H. (Anke-Hilse)
    In:Pharmacogenomics, 10(10), 1687 - 1695. ISSN 1462-2416.

    Abstract:

    The narrow therapeutic range and wide interpatient variability in dose requirement make anticoagulation response to coumarin derivatives unpredictable. As a result, patients require frequent monitoring to avert adverse effects and maintain therapeutic efficacy. Polymorphisms in VKORC1 and CYP2C9 joi

  • Etiology, management, and outcome of the Budd-Chiari syndrome (2009)Open access

    Authors:Murad, S.D. (Sarwa Darwish); Plessier, A. (Aurelie); Hernandez-Guerra, M. (Manuel); Fabris, F. (Federica Margherita); Eapen, C.E. (Chundamannil Eapen); Bahr, M.J. (Matthias); Trebicka, J. (Jonel); Morard, I. (Isabelle); Lasser, L. (Luc); Heller, J. (Jörg); Hadengue, A. (Antoine); Langlet, P. (Philippe); Miranda, H. (Helena Pessegueiro); Primignani, M. (Massimo); Elias, E. (Elwyn); Leebeek, F.W.G. (Frank); Rosendaal, F.R. (Frits); Garcia-Pagan, J.C. (Juan Carlos); Valla, D.C. (Dominique Charle); Janssen, H.L.A. (Harry)
    In:Annals of Internal Medicine, 151(3), 167 - 175. ISSN 0003-4819.

    Abstract:

    Background: The Budd-Chiari syndrome (BCS) is hepatic venous outflow obstruction. What is known about the syndrome is based on small studies of prevalent cases. Objective: To characterize the causes and treatment of incident BCS. Design: Consecutive case series of patients with incident BCS, enrolle

  • Extrahepatic portal vein thrombosis: aetiology and determinants of survival (2001)Open access

    Authors:Janssen, H.L.A. (Harry); Hansen, B.E. (Bettina); Hoek, van B. (Bart); Rosendaal, F.R. (Frits); Haagsma, E.B. (Els); Uum, van S.H.; Nieuwkerk, van C.M.; Adang, R.P.; Chamuleau, R.A.; Hattum, van J. (Jan); Vleggaar, F.P. (Frank); Wijnhoud, A.D. (Annemarie)
    In:Gut (English Edition): an international journal of gastroenterology & hepatology. ISSN 0017-5749.

    Abstract:

    BACKGROUND: Malignancy, hypercoagulability, and conditions leading to decreased portal flow have been reported to contribute to the aetiology of extrahepatic portal vein thrombosis (EPVT). Mortality of patients with EPVT may be associated with these concurrent medical conditions or

  • Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: results of a case-control study (2000)Open access

    Authors:Janssen, H.L.A. (Harry); Vandenbroucke, J.P.; Rosendaal, F.R. (Frits); Hoek, van B. (Bart); Meinardi, J.R.; Vleggaar, F.P. (Frank); Uum, van S.H.; Haagsma, E.B. (Els); Meer, van der F.J.; Hattum, van J. (Jan); Chamuleau, R.A.; Adang, R.P.
    In:Blood. ISSN 0006-4971.

    Abstract:

    In a collaborative multicenter case-control study, we investigated the effect of factor V Leiden mutation, prothrombin gene mutation, and inherited deficiencies of protein C, protein S, and antithrombin on the risk of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). We

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