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Dr. H. van Dekken

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  • Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma (2011)Open access

    Authors:Winkel, van de A. (Anouk); Menke, V. (Vivianda); Capello, A. (Astrid); Moons, L.M.G. (Leon); Pot, R.G.J. (Raymond); Dekken, van H. (Herman); Siersema, P.D. (Peter); Kusters, J.G. (Johannes); Laan, van der L.J.W. (Luc); Kuipers, E.J. (Ernst)
    In:B M C Gastroenterology, 11. ISSN 1471-230x.

    Abstract:

    Background: The continuous exposure of esophageal epithelium to refluxate may induce ectopic expression of bile-responsive genes and contribute to the development of Barrett's esophagus (BE) and esophageal adenocarcinoma. In normal physiology of the gut and liver, the nuclear receptor Pregnane × Rec

  • Biomarker-based prediction of inflammatory bowel disease-related colorectal cancer: a case–control study (2011)Open access

    Authors:Gerrits, M.M. (Monique); Chen, M. (Min); Theeuwes, J.J.M. (Myrte); Dekken, van H. (Herman); Sikkema, M. (Marjolein); Steyerberg, E.W. (Ewout); Lingsma, H.F. (Hester); Siersema, P.D. (Peter); Xia, B. (Bing); Kusters, J.G. (Johannes); Woude, van der C.J. (Janneke); Kuipers, E.J. (Ernst)
    In:Cellular Oncology, 34(2), 107 - 117. ISSN 1570-5870.

    Abstract:

    Regular colonoscopic surveillance for detection of dysplasia is recommended in longstanding inflammatory bowel disease (IBD), however, its sensitivity is disputed. Screening accuracy may increase by using a biomarker-based surveillance strategy.A case-control study was performed to determine the pro

  • Narrow band imaging for the detection of gastric intestinal metaplasia and dysplasia during surveillance endoscopy (2010)Open access

    Authors:Capelle, L.G. (Lisette); Haringsma, J. (Jelle); Vries, de A.C. (Annemarie Charlotte); Steyerberg, E.W. (Ewout); Biermann, K. (Katharina); Dekken, van H. (Herman); Kuipers, E.J. (Ernst)
    In:Digestive Diseases and Sciences, 55(12), 3442 - 3448. ISSN 0163-2116.

    Abstract:

    Background: Surveillance of premalignant gastric lesions relies mainly on random biopsy sampling. Narrow band imaging (NBI) may enhance the accuracy of endoscopic surveillance of intestinal metaplasia (IM) and dysplasia. We aimed to compare the yield of NBI to white light endoscopy (WLE) in the surv

  • Verification and unmasking of widely used human esophageal adenocarcinoma cell lines (2010)

    Authors:Boonstra, J.J. (Jurjen); Marion, van R. (Ronald); Beer, D.G. (David); Lin, L. (Lily); Chaves, P. (Paula); Ribeiro, C. (Catarina); Pereira, A.D. (Dias); Roque, L. (Lúcia); Darnton, S.J. (Jane); Altorki, N.K. (Nasser); Schrump, D.S. (David); Klimstra, D.S. (David); Tang, L.H. (Laura); Eshleman, J.R. (James); Alvarez, H. (Hector); Shimada, Y. (Yutaka); Dekken, van H. (Herman); Tilanus, H.W. (Hugo); Dinjens, W.N.M. (Winand)
    In:National Cancer Institute. Journal (Print), 102(4), 271 - 274. ISSN 0027-8874.

    Abstract:

    For decades, hundreds of different human tumor type-specific cell lines have been used in experimental cancer research as models for their respective tumors. The veracity of experimental results for a specific tumor type relies on the correct derivation of the cell line. In a worldwide effort, we ve

  • Neoadjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinoma or squamous cell carcinoma of the esophagus (CROSS) (2008)Open access

    Authors:Heijl, van M. (Mark); Lanschot, van J.J.B. (Jan); Koppert, L.B. (Linetta); Berge Henegouwen, van M.I. (Mark); Muller, K.; Steyerberg, E.W. (Ewout); Dekken, van H. (Herman); Wijnhoven, B.P.L. (Bas); Tilanus, H.W. (Hugo); Richel, D.J. (Dirk); Busch, O.R.C. (Olivier); Bartelsman, J.F.; Koning, C.C.E. (Caro); Offerhaus, G.J. (Johan); Gaast, van der A. (Ate)
    In:BMC Surgery, 8. ISSN 1471-2482.

    Abstract:

    Background. A surgical resection is currently the preferred treatment for esophageal cancer if the tumor is considered to be resectable without evidence of distant metastases (cT1-3 N0-1 M0). A high percentage of irradical resections is reported in studies using neoadjuvant chemotherapy followed by

  • Immunohistochemical evaluation of a panel of tumor cell markers during malignant progression in Barrett esophagus (2008)

    Authors:Dekken, van H. (Herman); Hop, W.C.J. (Wim); Tilanus, H.W. (Hugo); Haringsma, J. (Jelle); Valk, van der H.; Wink, J.C. (Josiane); Vissers, K.J. (Kees)
    In:American Journal of Clinical Pathology, 130(5), 745 - 753. ISSN 0002-9173.

    Abstract:

    Histopathologic grading of dysplasia in Barrett esophagus (BE) shows substantial interobserver and intraobserver variation. We used immunohistochemical analysis with a set of tumor cell markers, ie, epidermal growth factor receptor (EGFR), ERBB2 (HER2/neu), MYC, CDKN2A (p16), SMAD4, MET, CCND1 (cycl

  • Pancreatic fibrosis correlates with exocrine pancreatic insufficiency after pancreatoduodenectomy (2008)Open access

    Authors:Tran, T.C.; Hof, van 't G.; Kazemier, G. (Geert); Hop, W.C.J. (Wim); Pek, C.J. (Chulja); Toorenenbergen, van A.W. (Albert); Dekken, van H. (Herman); Eijck, van C.H.J. (Casper)
    In:Digestive Surgery, 25(4), 311 - 318. ISSN 0253-4886.

    Abstract:

    Background: Obstruction of the pancreatic duct can lead to pancreatic fibrosis. We investigated the correlation between the extent of pancreatic fibrosis and the postoperative exocrine and endocrine pancreatic function. Methods: Fifty-five patients who were treated for pancreatic and periampullary c

  • Somatostatin receptor in human hepatocellular carcinomas: Biological, patient and tumor characteristics (2008)Open access

    Authors:Verhoef, C. (Cornelis); Dekken, van H. (Herman); Hofland, L.J. (Leo); Zondervan, P.E. (Pieter); Wilt, de J.H.W. (Johannes); Marion, van R. (Ronald); Man, de R.A. (Robert); IJzermans, J.N.M. (Jan); Eijck, van C.H.J. (Casper)
    In:Digestive Surgery, 25(1), 21 - 26. ISSN 0253-4886.

    Abstract:

    Background/Aim: The evidence on the efficacy of somatostatin analogues in the treatment of hepatocellular carcinoma (HCC) in humans is conflicting. A variety of human tumors demonstrate somatostatin receptors. All subtypes bind human somatostatin with high affinity, while somatostatin analogues bind

  • The role of EXT1 in nonhereditary osteochondroma: Identification of homozygous deletions (2007)

    Authors:Hameetman, L. (Liesbeth); Szuhai, K. (Karoly); Yavas, A. (Ayse); Knijnenburg, J. (Jeroen); Duin, van M. (Mark); Dekken, van H. (Herman); Taminiau, A.H.M. (Antonie); Cleton-Jansen, A.; Bovée, J.V.M.G. (Judith V. M. G.); Hogendoorn, P.C.W. (Pancras)
    In:National Cancer Institute. Journal (Print), 99(5), 396 - 406. ISSN 0027-8874.

    Abstract:

    Background: Multiple osteochondromas is a hereditary syndrome that is characterized by the formation of cartilagecapped bony neoplasms (osteochondromas), for which exostosis (multiple)-1 (EXT1) has been identified as a causative gene. However, 85% of all osteochondromas present as solitary (nonhered

  • Expression of apoptosis related proteins during malignant progression in chronic ulcerative colitis (2005)Open access

    Authors:Woude, van der C.J. (Janneke); Moshage, H.; Homan, M.; Kleibeuker, J.H.; Jansen, P.L.M. (Peter); Dekken, van H. (Herman)
    In:Journal of Clinical Pathology: an international peer-reviewed journal for health professionals and researchers in clinical pathology. ISSN 0021-9746.

    Abstract:

    BACKGROUND: Chronic ulcerative colitis (CUC) is associated with increased risk of developing colon cancer through a dysplasia (intraepithelial neoplasia)-carcinoma sequence. AIMS: To investigate the expression of apoptosis and inflammatory related proteins in CUC. METHODS: The

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