Dr. H.E. Smith

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Wageningen University & Research Centre (30)

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Extended-spectrum-β-lactamase- and AmpC-β-lactamase-producing Escherichia coli in Dutch broilers and broiler farms (2013)

Authors:	Dierikx, C.M.; Goot, van der J.A.; Fabri, T.; Essen-Zandbergen, van A.; Smith, H.E.; Mevius, D.J.
In:	Journal of Antimicrobial Chemotherapy, 68(1), 60 - 67. ISSN 0305-7453.

Abstract:

Objectives The aim of this study was to establish the prevalence of extended-spectrum β-lactamase (ESBL)- and AmpC β-lactamase-producing Escherichia coli at Dutch broiler farms and in farmers and to compare ESBL/AmpC-producing isolates from farmers and their animals. Methods Twenty-five to 41 cloac

Lysozyme Resistance in Streptococcus suis Is Highly Variable and Multifactorial (2012)Open access

Authors: Wichgers, P.J.; Weeghel, van C.; Rebel, J.M.J.; Smits, M.A.; Putten, van J.P.M.; Smith, H.E.
In: PLoS One, 7(4). ISSN 1932-6203.

Abstract:
Background Streptococcus suis is an important infectious agent for pigs and occasionally for humans. The host innate immune system plays a key role in preventing and eliminating S. suis infections. One important constituent of the innate immune system is the protein lysozyme, which is present in a
Immunomodulatory effects of streptococcus suis capsule type on human dendritic cell responses, phagocytosis and intracellular survival. (2012)Open access

Authors: Meijerink, M.; Ferrando, M.L.; Lammers, G.; Taverne, N.; Smith, H.E.; Wells, J.M.
In: PLoS One, 7(4). ISSN 1932-6203.

Abstract:
Streptococcus suis is a major porcine pathogen of significant commercial importance worldwide and an emerging zoonotic pathogen of humans. Given the important sentinel role of mucosal dendritic cells and their importance in induction of T cell responses we investigated the effect of different S. sui
Lgt processing is an essential step in Streptococcus suis lipoprotein mediated innate immune activation (2011)Open access

Authors: Wichgers, P.J.; Rebel, J.M.J.; Smits, M.A.; Putten, van J.P.; Smith, H.E.
In: PLoS One, 6(7). ISSN 1932-6203.

Abstract:
Background Streptococcus suis causes invasive infections in pigs and occasionally in humans. The host innate immune system plays a major role in counteracting S. suis infections. The main components of S. suis able to activate the innate immune system likely include cell wall constituents that may b

Authors:	Wichgers, P.J.; Weeghel, van C.; Rebel, J.M.J.; Smits, M.A.; Putten, van J.P.M.; Smith, H.E.
In:	PLoS One, 7(4). ISSN 1932-6203.

Authors:	Meijerink, M.; Ferrando, M.L.; Lammers, G.; Taverne, N.; Smith, H.E.; Wells, J.M.
In:	PLoS One, 7(4). ISSN 1932-6203.

Authors:	Wichgers, P.J.; Rebel, J.M.J.; Smits, M.A.; Putten, van J.P.; Smith, H.E.
In:	PLoS One, 6(7). ISSN 1932-6203.

Genetic diversity of Streptococcus suis isolates as determined by comparative genome hybridization (2011)Open access

Authors:	Greeff, de A.; Wisselink, H.J.; Bree, de F.M.; Schultsz, C.; Baums, C.G.; Ngo Thi, Hoa; Stockhofe-Zurwieden, N.; Smith, H.E.
In:	BMC Microbiology, 11. ISSN 1471-2180.

Abstract:

Background Streptococcus suis is a zoonotic pathogen that causes infections in young piglets. S. suis is a heterogeneous species. Thirty-three different capsular serotypes have been described, that differ in virulence between as well as within serotypes.Results In this study, the correlation between

Strengthening insights into host responses to mastitis infection in ruminants by combining heterogeneous microarray data sources (2011)Open access

Authors:	Genini, S.; Badaoui, B.; Sclep, G.; Bishop, S.C.; Waddington, D.; Pinard van der Laan, M.H.; Klopp, Ch.; Cabau, C.; Seyfert, H.M.; Petzl, W.; Jensen, K.; Glass, E.J.; Greeff, de A.; Smith, H.E.; Smits, M.A.; Olsaker, I.; Boman, G.M.; Pisoni, G.; Moroni, P.; Castiglioni, B.; Cremonesi, P.; Corvo, del M.; Foulon, E.; Foucras, G.; Rupp, R.; Giuffra, E.
In:	BMC Genomics, 12. ISSN 1471-2164.

Abstract:

Background - Gene expression profiling studies of mastitis in ruminants have provided key but fragmented knowledge for the understanding of the disease. A systematic combination of different expression profiling studies via meta-analysis techniques has the potential to test the extensibility of conc

TroA of Streptococcus suis is required for manganese acquisition and full virulence (2011)

Authors: Wichgers Schreur, P.J.; Rebel, J.M.J.; Smits, M.A.; Putten, van J.P.M.; Smith, H.E.
In: Journal of Bacteriology, 193(19), 5073 - 5080. ISSN 0021-9193.

Abstract:
Streptococcus suis causes infections in pigs and occasionally in humans resulting in 23 manifestations as meningitis, sepsis, arthritis and septic shock. For survival within the 24 host, S. suis requires numerous nutrients including trace metals. Little is known about 25 the specific proteins involv
Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis (2011)

Authors: Willenborg, J.; Fulde, M.; De Greeff, A.; Rohde, M.; Smith, H.E.; Valentin-Weigand, P.; Goethe, R.
In: Microbiology, 157(6), 1823 - 1833. ISSN 1350-0872.

Abstract:
Streptococcus suis is one of the most important pathogens in pigs and is also an emerging zoonotic agent. After crossing the epithelial barrier, S. suis causes bacteraemia, resulting in meningitis, endocarditis and bronchopneumonia. Since the host environment seems to be an important regulatory comp
ArgR is an essential local transcriptional regulator of the arcABC-operon in Streptococcus suis and crucial for biological fitness in acidic environment (2011)

Authors: Fulde, M.; Willenborg, J.; Greeff, de A.; Benga, L.; Smith, H.E.; Valentin-Weigand, P.; Goethe, R.
In: Microbiology, 157(2), 572 - 582. ISSN 1350-0872.

Abstract:
Streptococcus suis is one of the most important pathogens in pigs and can also cause severe infections in humans. Despite its clinical relevance very little is known about the factors contributing to its virulence. Recently, we identified a new putative virulence factor in Streptococcus suis, the ar
Differential activation of the Toll-like receptor 2/6 complex by lipoproteins of Streptococcus suis serotypes 2 and 9 (2010)

Authors: Wichgers, P.J.; Rebel, J.M.J.; Smits, M.A.; Putten, van J.P.; Smith, H.E.
In: Veterinary Microbiology, 143(2-4), 363 - 370. ISSN 0378-1135.

Abstract:
Streptococcus suis causes invasive infections in pigs and occasionally in humans. Worldwide, S. suis serotype 2 is most frequently isolated from diseased piglets, but the less virulent serotype 9 is emerging, at least in Europe. We compared the activation of human Toll-like receptors (hTLRs) by S. s

Authors:	Wichgers Schreur, P.J.; Rebel, J.M.J.; Smits, M.A.; Putten, van J.P.M.; Smith, H.E.
In:	Journal of Bacteriology, 193(19), 5073 - 5080. ISSN 0021-9193.

Authors:	Willenborg, J.; Fulde, M.; De Greeff, A.; Rohde, M.; Smith, H.E.; Valentin-Weigand, P.; Goethe, R.
In:	Microbiology, 157(6), 1823 - 1833. ISSN 1350-0872.

Authors:	Fulde, M.; Willenborg, J.; Greeff, de A.; Benga, L.; Smith, H.E.; Valentin-Weigand, P.; Goethe, R.
In:	Microbiology, 157(2), 572 - 582. ISSN 1350-0872.

Authors:	Wichgers, P.J.; Rebel, J.M.J.; Smits, M.A.; Putten, van J.P.; Smith, H.E.
In:	Veterinary Microbiology, 143(2-4), 363 - 370. ISSN 0378-1135.

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