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Noninferiority (NI) trials in drug research are used for the
purpose of demonstrating that a new treatment is not worse
than a proven active comparator, thereby indirectly showing
that the treatment is effective. This article explains and
addresses the complications in the interpretation of NI trial
Background and aims. Clinical inertia is considered a major barrier to better care. We assessed
its prevalence, predictors and associations with the intermediate outcomes of diabetes care.
Materials and methods. Baseline and follow-up data of a Dutch randomized controlled trial on
Despite initial enthusiasm,1–3 the use of pharmacogenetics has
remained limited to investigation in only a few clinical fields
such as oncology and psychiatry.4–8 The main reason is the
paucity of scientific evidence to show that pharmacogenetic
testing leads to improved clinical outcomes.9,10 Moreo
Background: Use of inhaled corticosteroids may reduce the risk of acute myocardial infarction (MI) through reductions in systemic inflammation and C-reactive protein.
Objectives: To examine the association between the use of inhaled corticosteroids and the risk of non-fatal acute MI.
Methods: In t
To investigate if patients’ perceptions of their diabetes status is related to blood glucose self-monitoring (SMBG) behaviour, independent of self-reported disease severity.
The setting of this study was a cross-sectional study among 1561 patients, 18 years or older, who filled at leas
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
• Use of β2 agonists has been associated with tachycardia, an abnormal ECG and atrial fibrillation.
• Previous observational studies of the association between use of β2 agonists and the risk of acute myocardial infarction (MI) have demonstrated conflictin
Purpose To compare adjusted effects of drug treatment for hypertension on the risk of stroke from propensity score (PS)
methods with a multivariable Cox proportional hazards (Cox PH) regression in an observational study with censored data.
Methods From two prospective population-based cohort studies
Little is known about cross-national
comparisons of the persistence of antihypertensive
medication treatment, trends in persistence, and factors
associated with persistence. The aim of this study was to
describe and compare patterns of use of antihypertensive
drugs in a population of elderly patient
Background: Treatment with vitamin K antagonists
(coumarins) is associated with an increased risk of bleeding.
Because use of selective serotonin reuptake inhibitors
(SSRIs) is also associated with an increased risk of
bleeding, we assessed the odds ratio (OR) of abnormal
bleeding associated with SS
Objective: To investigate if disturbed glucose homeostasis or known diagnosis of diabetes was associated with depressive
symptoms. The reason for the increased prevalence of depression in patients with Type 2 diabetes mellitus (DM2) is unknown.
Methods: Within the Utrecht Health Project, an ongoing
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