Noninferiority (NI) trials in drug research are used for the purpose of demonstrating that a new treatment is not worse than a proven active comparator, thereby indirectly showing that the treatment is effective. This article explains and addresses the complications in the interpretation of NI trial
Background and aims. Clinical inertia is considered a major barrier to better care. We assessed its prevalence, predictors and associations with the intermediate outcomes of diabetes care. Materials and methods. Baseline and follow-up data of a Dutch randomized controlled trial on the implementation
Despite initial enthusiasm,1–3 the use of pharmacogenetics has remained limited to investigation in only a few clinical fields such as oncology and psychiatry.4–8 The main reason is the paucity of scientific evidence to show that pharmacogenetic testing leads to improved clinical outcomes.9,10 Moreo
Background: Use of inhaled corticosteroids may reduce the risk of acute myocardial infarction (MI) through reductions in systemic inflammation and C-reactive protein. Objectives: To examine the association between the use of inhaled corticosteroids and the risk of non-fatal acute MI. Methods: In t
Aims To investigate if patients’ perceptions of their diabetes status is related to blood glucose self-monitoring (SMBG) behaviour, independent of self-reported disease severity. Methods The setting of this study was a cross-sectional study among 1561 patients, 18 years or older, who filled at leas
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Use of β2 agonists has been associated with tachycardia, an abnormal ECG and atrial fibrillation. • Previous observational studies of the association between use of β2 agonists and the risk of acute myocardial infarction (MI) have demonstrated conflictin
Purpose To compare adjusted effects of drug treatment for hypertension on the risk of stroke from propensity score (PS) methods with a multivariable Cox proportional hazards (Cox PH) regression in an observational study with censored data. Methods From two prospective population-based cohort studies
Little is known about cross-national comparisons of the persistence of antihypertensive medication treatment, trends in persistence, and factors associated with persistence. The aim of this study was to describe and compare patterns of use of antihypertensive drugs in a population of elderly patient
Background: Treatment with vitamin K antagonists (coumarins) is associated with an increased risk of bleeding. Because use of selective serotonin reuptake inhibitors (SSRIs) is also associated with an increased risk of bleeding, we assessed the odds ratio (OR) of abnormal bleeding associated with SS
Objective: To investigate if disturbed glucose homeostasis or known diagnosis of diabetes was associated with depressive symptoms. The reason for the increased prevalence of depression in patients with Type 2 diabetes mellitus (DM2) is unknown. Methods: Within the Utrecht Health Project, an ongoing
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