11-20 out of 87 results
Intensive blood glucose lowering can significantly reduce the risk of micro- and macrovascular complications
in patients with diabetes mellitus. However, 30% of all treated patients do not achieve optimal blood glucose
levels. Genetic factors may influence the response to glucose-lowering medication
Objective: To assess patterns of restarting antihypertensive
drugs after a prolonged period of discontinuation.
Methods: We conducted a retrospective cohort study
among new users of blood pressure-lowering
medication in the PHARMO database in the Netherlands,
who had a period of at least 180 days wi
Angiotensinogen is an essential component of the renin-angiotensin system. ACE-inhibitors and b-blockers
both have a direct influence on this system. To investigate whether the association between use of
ACE-inhibitors or b-blockers and the risk of myocardial infarction (MI) or stroke is modified by
Background The aim of this study was to determine whether the angiotensin-converting enzyme (ACE) insertiondeletion
(ID) polymorphism interacts with pravastatin to modify the risk of coronary heart disease (CHD) and other
cardiovascular end points in a large clinical trial.
Methods GenHAT is an anci
The wide availability of economic evaluations and their increasing importance
for decision making emphasises the need for economic evaluations that are
methodologically sound. The aim of this review was to provide users of economic
evaluations of cholesterol-lowering drugs with an insight into the q
In a recent simulation study Austin et al. conclude that conditioning on the propensity score gives
biased estimates of the true conditional odds ratio of treatment effect in logistic regression analysis.
Although we generally agree with this conclusion, it can be easily misinterpreted because of th
To investigate whether the angiotensin-converting enzyme (ACE) insertion/deletion
(I/D), angiotensinogen M235T or angiotensin II receptor type 1 573C/T polymorphism
modify the risk of atherosclerosis associated with b-blocker or ACE-inhibitor therapy.
Data were used from the Rotterdam
Current regulations focus on the mandatory safety evaluation of functional foods before they come to market, but Nynke de Jong and colleagues argue that the effects of such foods should also be evaluated after they have been launched.
Objective: To determine if the association between the
level of community pharmacy diabetes services and six of
its reported determinants is influenced by the definition of
Method: Cross-sectional survey among 97% of all Dutch
community pharmacies (1,642) registered in 2004. Seven
To assess the potential annual savings due to generic and therapeutic substitution of
statin therapy for the general Dutch population, taking the patients medical history into
We conducted a population-based costing study using the PHARMO Record Linkage
System (RLS). PHARMO R
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