Dr. J. Heesakkers

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Radboud Universiteit Nijmegen (50)

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Adherence junctions and cadherin-11 in normal and overactive human detrusor smooth muscle cells (2011)

Auteurs: Kuijpers, K.A.J.; Heesakkers, J.P.F.A.; Hafmans, T.G.M.; Schalken, J.A.
In: Journal of Urology, 185, 1946 - 1951. ISSN 0022-5347.

Samenvatting:
PURPOSE: We investigated whether analysis of adherence junctions in human detrusor could be used as a diagnostic tool to determine detrusor overactivity. MATERIALS AND METHODS: We characterized the protein composition of adherence junctions in the human bladder using cadherin-11 since our group prev
Feasibility of noninvasive near-infrared spectroscopy to diagnose detrusor overactivity (2011)

Auteurs: Farag, F.; Martens, F.M.J.; Feitz, W.F.J.; Heesakkers, J.P.F.A.
In: Urologia Internationalis, 87, 330 - 335. ISSN 0042-1138.

Samenvatting:
Introduction: Near-infrared spectroscopy (NIRS) is an optical technology able to detect the hemodynamic changes in biological tissues. Our objective was to determine the feasibility of applying NIRS in the noninvasive diagnosis of detrusor overactivity (DO). Patients and Methods: Comparative analysi
Minimal invasive electrode implantation for conditional stimulation of the dorsal genital nerve in neurogenic detrusor overactivity (2011)

Auteurs: Martens, F.M.J.; Heesakkers, J.P.F.A.; Rijkhoff, N.J.M.
In: Spinal Cord, 49, 566 - 572. ISSN 1362-4393.

Samenvatting:
STUDY DESIGN: Experimental. OBJECTIVES: Electrical stimulation of the dorsal genital nerves (DGN) suppresses involuntary detrusor contractions (IDCs) in patients with neurogenic detrusor overactivity (DO). The feasibility of minimal invasive electrode implantation near the DGN and the effectiveness
Near-infrared spectroscopy: a novel, noninvasive, diagnostic method for detrusor overactivity in patients with overactive bladder symptoms--a preliminary and experimental study (2011)

Auteurs: Farag, F.; Martens, F.M.J.; Hauwers, K.W.M. d'; Feitz, W.F.J.; Heesakkers, J.P.F.A.
In: European Urology, 59, 757 - 762. ISSN 0302-2838.

Samenvatting:
BACKGROUND: Near-infrared spectroscopy (NIRS) is an optical technology. It detects the hemodynamic changes in tissues via noninvasive measurement of changes in the concentration of tissue chromophores such as oxyhemoglobin (O(2)Hb) and deoxyhemoglobin (HHb). Involuntary bladder contractions may caus
The mechanoreceptor TRPV4 is localized in adherence junctions of the human bladder urothelium: a morphological study (2011)

Auteurs: Janssen, D.A.W.; Hoenderop, J.G.J.; Jansen, K.C.; Kemp, A.W.; Heesakkers, J.P.F.A.; Schalken, J.A.
In: Journal of Urology, 186, 1121 - 1127. ISSN 0022-5347.

Samenvatting:
PURPOSE: TRPV4 (transient receptor potential vanilloid 4 channel) is a nonselective cation channel involved in different sensory functions that was recently implicated in bladder mechanosensation. We investigated the cellular site of TRPV4 in bladder urothelium and explored a molecular connection be

Auteurs:	Kuijpers, K.A.J.; Heesakkers, J.P.F.A.; Hafmans, T.G.M.; Schalken, J.A.
In:	Journal of Urology, 185, 1946 - 1951. ISSN 0022-5347.

Auteurs:	Farag, F.; Martens, F.M.J.; Feitz, W.F.J.; Heesakkers, J.P.F.A.
In:	Urologia Internationalis, 87, 330 - 335. ISSN 0042-1138.

Auteurs:	Martens, F.M.J.; Heesakkers, J.P.F.A.; Rijkhoff, N.J.M.
In:	Spinal Cord, 49, 566 - 572. ISSN 1362-4393.

Auteurs:	Farag, F.; Martens, F.M.J.; Hauwers, K.W.M. d'; Feitz, W.F.J.; Heesakkers, J.P.F.A.
In:	European Urology, 59, 757 - 762. ISSN 0302-2838.

Auteurs:	Janssen, D.A.W.; Hoenderop, J.G.J.; Jansen, K.C.; Kemp, A.W.; Heesakkers, J.P.F.A.; Schalken, J.A.
In:	Journal of Urology, 186, 1121 - 1127. ISSN 0022-5347.

Efficacy and safety of onabotulinumtoxinA in patients with urinary incontinence due to neurogenic detrusor overactivity: a randomised, double-blind, placebo-controlled trial. (2011)

Auteurs:	Cruz, F.; Herschon, S.; Aliotta, P.; Brin, M.; Thompson, C.; Lam, W.; Daniell, G.; Heesakkers, J.P.F.A.; Haag-Molkenteller, C.
In:	European Urology, 60, 742 - 750. ISSN 0302-2838.

Non-invasive techniques in the diagnosis of bladder storage disorders (2011)

Auteurs: Farag, F.; Heesakkers, J.P.F.A.
In: Neurourology and Urodynamics, 30, 1422 - 1428. ISSN 0733-2467.

Samenvatting:
AIMS: To review clinical studies thus have been conducted to develop non-invasive diagnostic tools in the storage phase of the micturition cycle. METHODS: Pub Med and Web of Science searches were carried out. The search covered the published data of non-invasive diagnostic techniques for detrusor ov
Re: Jürgen Pannek. Mozart, the brain, and the bladder: clinical usefulness of near-infrared spectroscopy for the detection of detrusor overactivity. Eur Urol 2011;59:763-4. (2011)

Auteurs: Heesakkers, J.P.; Farag, F.
In: European Urology, 60, e49 - e49. ISSN 0302-2838.
Surgical access for electrical stimulation of the pudendal and dorsal genital nerves in the overactive bladder: a review (2011)

Auteurs: Martens, F.M.J.; Heesakkers, J.P.F.A.; Rijkhoff, N.J.M.
In: Journal of Urology, 186, 798 - 804. ISSN 0022-5347.

Samenvatting:
PURPOSE: The anatomy of the pudendal nerve and its nerve branches, especially the dorsal nerve of the penis and clitoris (dorsal genital nerves), and the clinical application of electrical stimulation of these nerves in patients with overactive bladder syndrome and detrusor overactivity are reviewed
Clinical results of a brindley procedure: sacral anterior root stimulation in combination with a rhizotomy of the dorsal roots (2011)

Auteurs: Martens, F.M.J.; Heesakkers, J.P.F.A.
In: Advances in Urology, 2011, 709708 - 709708. ISSN 1687-6369.

Samenvatting:
The Brindley procedure consists of a stimulator for sacral anterior-root stimulation and a rhizotomy of the dorsal sacral roots to abolish neurogenic detrusor overactivity. Stimulation of the sacral anterior roots enables micturition, defecation, and erections. This overview discusses the technique,

Auteurs:	Farag, F.; Heesakkers, J.P.F.A.
In:	Neurourology and Urodynamics, 30, 1422 - 1428. ISSN 0733-2467.

Auteurs:	Heesakkers, J.P.; Farag, F.
In:	European Urology, 60, e49 - e49. ISSN 0302-2838.

Auteurs:	Martens, F.M.J.; Heesakkers, J.P.F.A.; Rijkhoff, N.J.M.
In:	Journal of Urology, 186, 798 - 804. ISSN 0022-5347.

Auteurs:	Martens, F.M.J.; Heesakkers, J.P.F.A.
In:	Advances in Urology, 2011, 709708 - 709708. ISSN 1687-6369.

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