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Prof.dr. W.L. de Laat Persoon

Prof.dr. W.L. de Laat

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  • Interactions among Polycomb Domains Are Guided by Chromosome Architecture (2011)Open access

    Auteurs:Tolhuis, B.; Blom, M.; Kerkhoven, R.M.; Pagie, L.; Teunissen, H.; Nieuwland, M.; Simonis, M.; Laat, de W.; Lohuizen, van M.; Steensel, van B.
    In:PLoS Genetics, 7, e1001343. ISSN 1553-7390.

    Samenvatting:

    Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes. Here, we adapted the Chromosome Conformation Capture on Chip (4C) assay to systematically map chromosomal in

  • Genome organization influences partner selection for chromosomal rearrangements (2010)

    Auteurs:Wijchers, P. J.; Laat, de W.
    In:Trends in Genetics. ISSN 0168-9525.

    Samenvatting:

    Chromosomal rearrangements occur as a consequence of the erroneous repair of DNA double-stranded breaks, and often underlie disease. The recurrent detection of specific tumorigenic rearrangements suggests that there is a mechanism behind chromosomal partner selection involving the shape of the genom

  • Transcription and chromatin organization of a housekeeping gene cluster containing an integrated β-globin locus control region (2008)

    Auteurs:Noordermeer, D. (Daan); Branco, M.R. (Miguel); Splinter, D. (Daniël); Klous, P. (Petra); IJcken, van W.F.J. (Wilfred); Swagemakers, S.M.A. (Sigrid); Koutsourakis, M. (Manousos); Spek, van der P.J. (Peter); Pombo, A. (Ana); Laat, de W.L. (Wouter)
    In:P L o S Genetics (Print), 4(3). ISSN 1553-7390.

    Samenvatting:

    The activity of locus control regions (LCR) has been correlated with chromatin decondensation, spreading of active chromatin marks, locus repositioning away from its chromosome territory (CT), increased association with transcription factories, and long-range interactions via chromatin looping. To i

  • Maintenane of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription (2008)Open access

    Auteurs:Palstra, R.J.T.S.; Simonis, M. (Marieke); Klous, P. (Petra); Brasset, E. (Emilie); Eijkelkamp, B. (Bart); Laat, de W.L. (Wouter)
    In:PLoS ONE, 3(2). ISSN 1932-6203.

    Samenvatting:

    A relationship exists between nuclear architecture and gene activity and it has been proposed that the activity of ongoing RNA polymerase II transcription determines genome organization in the mammalian cell nucleus. Recently developed 3C and 4C technology allowed us to test the importance of transc

  • Multiple interactions between regulatory regions are required to stabilize an active chromatin hub. (2004)Open access

    Auteurs:Patrinos, G.P. (George); Krom, de M. (Mariken); Boer, de E. (Ernie); Langeveld, A. (An); Imam, A.M.A. (Ali); Strouboulis, J. (John); Laat, de W.L. (Wouter); Grosveld, F.G. (Frank)
    In:Genes & Development, 18(12), 1495 - 1509. ISSN 0890-9369.

    Samenvatting:

    The human beta-globin locus control region (LCR) is required for the maintenance of an open chromatin configuration of the locus. It interacts with the genes and the hypersensitive regions flanking the locus to form an active chromatin hub (ACH) transcribing the genes. Proper developmental control o

  • Molecular mechanism of nucleotide excision repair (1999)Open access

    Auteurs:Laat, de W.L. (Wouter); Hoeijmakers, J.H.J. (Jan); Jaspers, N.G.J. (Nicolaas)
    In:Genes & Development. ISSN 0890-9369.

  • Mapping of the interaction domains between human repair proteins ERCC1 and XPF. (1998)Open access

    Auteurs:Laat, de W.L. (Wouter); Sijbers, A.M. (Anneke); Odijk, H. (Hanny); Appeldoorn, E. (Esther); Jaspers, N.G.J. (Nicolaas); Hoeijmakers, J.H.J. (Jan)
    In:Nucleic Acids Research, 26(18), 4146 - 4152. ISSN 0305-1048.

    Samenvatting:

    ERCC1-XPF is a heterodimeric protein complexinvolved in nucleotide excision repair and recombinational processes. Like its homologous complex in Saccharomyces cerevisiae , Rad10-Rad1, it acts as a structure-specific DNA endonuclease, cleaving at duplex-single-stranded DNA junctions. In repair, ERCC1

  • Incision Coordination in Nucleotide Excision Repair (1998)Open access

    Auteur:Laat, de W.L. (Wouter)

    Samenvatting:

    This thesis aims to contribute to the understanding of the molecular mechanism that underlies one of the main DNA repair pathways in mammals, nucleotide excision rcpair. In chapter 1 the relevance of DNA repair in general is outlined. An overview of mammalian strategies to counteract DNA damage is p

  • DNA structural elements required for ERCC1-XPF endonuclease activity (1998)Open access

    Auteurs:Laat, de W.L. (Wouter); Appeldoorn, E. (Esther); Hoeijmakers, J.H.J. (Jan); Jaspers, N.G.J. (Nicolaas)
    In:Journal of Biological Chemistry. ISSN 0021-9258.

    Samenvatting:

    The heterodimeric complex ERCC1-XPF is a structure-specific endonuclease responsible for the 5' incision during mammalian nucleotide excision repair (NER). Additionally, ERCC1-XPF is thought to function in the repair of interstrand DNA cross-links and, by analogy to the homologous

  • DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair (1998)Open access

    Auteurs:Laat, de W.L. (Wouter); Appeldoorn, E. (Esther); Sugasawa, K. (Kaoru); Weterings, E. (Eric); Hoeijmakers, J.H.J. (Jan); Jaspers, N.G.J. (Nicolaas)
    In:Genes & Development. ISSN 0890-9369.

    Samenvatting:

    The human single-stranded DNA-binding replication A protein (RPA) is involved in various DNA-processing events. By comparing the affinity of hRPA for artificial DNA hairpin structures with 3'- or 5'-protruding single-stranded arms, we found that hRPA binds ssDNA with a defined

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