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Prof.dr. M. den Heijer

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  • Usefulness of intraoperative parathyroid hormone measurements in patients with renal hyperparathyroidism. (2010)

    Authors:Freriks, K.; Hermus, A.R.M.M.; Sevaux, R.G.L. de; Bonenkamp, J.J.; Biert, J.; Heijer, M. den; Sweep, F.C.; Hamersvelt, H.W. van
    In:Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 32, 1328 - 1335. ISSN 1043-3074.

    Abstract:

    BACKGROUND: In renal hyperparathyroidism, it remains unclear whether intraoperative parathyroid hormone (PTH) measurements can predict postoperative outcome and guide the extent of surgical exploration. METHODS: In 42 parathyroidectomies for renal hyperparathyroidism, we analyzed the predictive valu

  • Maternal homocysteine and related B vitamins as risk factors for low birthweight. (2010)

    Authors:Hogeveen, M.; Blom, H.J.; Heijden, E.H.M. van der; Semmekrot, B.A.; Sporken, J.M.J.; Ueland, P.M.; Heijer, M. den
    In:American Journal of Obstetrics and Gynecology, 202, 572.e1 - 572.e6. ISSN 0002-9378.

    Abstract:

    OBJECTIVE: We designed a large prospective study to explore the relationship between maternal homocysteine concentrations and related B vitamins and birthweight. STUDY DESIGN: Blood was sampled from pregnant women at 30-34 weeks of gestation and their newborn infants (n = 366). RESULTS: Concentratio

  • Impact of waist circumference versus adiponectin level on subclinical atherosclerosis: a cross-sectional analysis in a sample from the general population. (2010)

    Authors:Holewijn, S.; Heijer, M. den; Tits, L.J.H. van; Swinkels, D.W.; Stalenhoef, A.F.H.; Graaf, J. de
    In:Journal of Internal Medicine, 267, 588 - 598. ISSN 0954-6820.

    Abstract:

    OBJECTIVE: Waist circumference is a clinical marker of obesity and an established risk factor for cardiovascular (CV) disease. Adiponectin, an adipocyte-derived hormone and new biomarker of obesity, was recently proposed as the missing link between obesity and increased cardiovascular risk. We evalu

  • Androgenic alopecia is not useful as an indicator of men at high risk of prostate cancer. (2010)

    Authors:Cremers, R.G.H.M.; Aben, K.K.H.; Vermeulen, S.; Heijer, M. den; Oort, I.M. van; Kiemeney, L.A.L.M.
    In:European Journal of Cancer, 46, 3294 - 3299. ISSN 0959-8049.

    Abstract:

    BACKGROUND: Androgens are assumed to play a central role in the pathophysiology of both prostate cancer (PC) and androgenic alopecia (AA). A correlation between the two phenotypes may be relevant for identification of men at high risk of PC. We evaluated the association between AA at different ages

  • Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis. (2010)

    Authors:Bergboer, J.G.M.; Zeeuwen, P.L.J.M.; Irvine, A.D.; Weidinger, S.; Giardina, E.; Novelli, G.; Heijer, M. den; Rodriguez, E.; Illig, T.; Riveira-Munoz, E.; Campbell, L.E.; Tyson, J.; Dannhauser, E.N.; O'Regan, G.M.; Galli, E.; Klopp, N.; Koppelman, G.H.; Novak, N.; Estivill, X.; McLean, W.H.I.; Postma, D.S.; Armour, J.A.; Schalkwijk, J.
    In:Journal of Investigative Dermatology, 130, 2057 - 2061. ISSN 0022-202x.

    Abstract:

    Atopic dermatitis (AD) and psoriasis are common skin diseases characterized by cutaneous inflammation and disturbed epidermal differentiation. Genome-wide analyses have shown overlapping susceptibility loci, such as the epidermal differentiation complex on chromosome 1q21. Recently, a deletion on 1q

  • Apolipoprotein B, non-HDL cholesterol and LDL cholesterol for identifying individuals at increased cardiovascular risk. (2010)

    Authors:Holewijn, S.; Heijer, M. den; Swinkels, D.W.; Stalenhoef, A.F.H.; Graaf, J. de
    In:Journal of Internal Medicine, 268, 567 - 577. ISSN 0954-6820.

    Abstract:

    BACKGROUND: To compare apolipoprotein B (apoB), non-high-density lipoprotein-cholesterol (non-HDL-c) and low-density lipoprotein-cholesterol (LDL-c) for identifying individuals with a deteriorated cardiovascular (CV) risk profile, including a panel of subclinical atherosclerosis measurements and pre

  • Hundreds of variants clustered in genomic loci and biological pathways affect human height. (2010)

    Authors:Lango Allen, H.; Estrada, K.; Lettre, G.; Berndt, S.I.; Weedon, M.N.; Rivadeneira, F.; Willer, C.J.; Jackson, A.U.; Vedantam, S.; Raychaudhuri, S.; Ferreira, T.; Wood, A.R.; Weyant, R.J.; Segrè, A.V.; Speliotes, E.K.; Wheeler, E.; Soranzo, N.; Park, J.H.; Yang, J.; Gudbjartsson, D.F.; Heard-Costa, N.L.; Randall, J.; Vernon Smith, A.; Mägi, R.; Pastinen, T.; Liang, L.; Heid, I.M.; Luan, J.; Thorleifsson, G.; Winkler, T.W.; Goddard, M.E.; Sin Lo, K.; Palmer, C.N.; Workalemahu, T.; Aulchenko, Y.S.; Johansson, A.; Zillikens, M.C.; Feitosa, M.F.; Esko, T.; Johnson, T.; Ketkar, S.; Kraft, P.; Mangino, M.; Prokopenko, I.; Absher, D.; Albrecht, E.; Ernst, F.; Glazer, N.L.; Hayward, C.; Hottenga, J.J.; Jacobs, K.B.; Knowles, J.W.; Kutalik, Z.; Monda, K.L.; Polasek, O.; Preuss, M.; Rayner, N.W.; Robertson, N.R.; Steinthorsdottir, V.; Tyrer, J.P.; Voight, B.F.; Wiklund, F.; Xu, J.; Hua Zhao, J.; Nyholt, D.R.; Pellikka, N.; Perola, M.; Perry, J.R.; Surakka, I.; Tammesoo, M.L.; Altmaier, E.L.; Aben, K.K.H.; Kiemeney, L.A.L.M.; Heijer, M. den
    In:Nature, 467, 832 - 838. ISSN 0028-0836.

  • Association of variants at UMOD with chronic kidney disease and kidney stones : role of age and comorbid diseases (2010)Open access

    Authors:Gudbjartsson, D.F.; Holm, H.; Indridason, O.S.; Thorleifsson, G.; Edvardsson, V.; Sulem, P.; Vegt, F. de; D'Ancona, F.C.H.; Heijer, M. den; Franzson, L.; Rafnar, T.; Kristjansson, K.; Bjornsdottir, U.S.; Eyjolfsson, G.I.; Kiemeney, L.A.L.M.; Kong, A.; Palsson, R.; Thorsteinsdottir, U.; Stefansson, K.
    In:PLoS Genetics, 6, e1001039 - e1001039. ISSN 1553-7390.

    Abstract:

    Chronic kidney disease (CKD) is a worldwide public health problem that is associated with substantial morbidity and mortality. To search for sequence variants that associate with CKD, we conducted a genome-wide association study (GWAS) that included a total of 3,203 Icelandic cases and 38,782 contro

  • Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. (2010)

    Authors:Gretarsdottir, S.; Baas, A.F.; Thorleifsson, G.; Holm, H.; Heijer, M. den; Vries, J.P. de; Kranendonk, S.E.; Zeebregts, C.J.A.; Sterkenburg, S.M. van; Geelkerken, R.H.; Rij, A.M. van; Williams, M.J.; Boll, A.P.M.; Kostic, J.; Jonasdottir, A.; Jonasdottir, A.; Walters, G.B.; Masson, G.; Sulem, P.; Saemundsdottir, J.; Mouy, M.; Magnusson, K.P.; Tromp, G.; Elmore, J.B.; Sakalihasan, N.; Limet, R.; Defraigne, J.O.; Ferrell, R.E.; Ronkainen, A.; Ruigrok, Y.M.; Wijmenga, C.; Grobbee, D.E.; Shah, S.H.; Granger, C.B.; Quyyumi, A.A.; Vaccarino, V.; Patel, R.; Zafari, A.M.; Levey, A.I.; Austin, H.; Girelli, D.; Pignatti, P.F.; Olivieri, O.; Martinelli, N.; Malerba, G.; Trabetti, E.; Becker, L.C.; Becker, D.M.; Reilly, M.P.; Rader, D.J.; Mueller, T.; Dieplinger, B.; Haltmayer, M.; Urbonavicius, S.; Lindblad, B.; Gottsäter, A.; Gaetani, E.; Pola, R.; Wells, P.; Rodger, M.; Forgie, M.; Langlois, N.; Corral, J.; Vicente, V.; Fontcuberta, J.; España, F.; Grarup, N.; Jørgensen, T.; Witte, D.R.; Hansen, T.; Pedersen, O.; Aben, K.K.H.; Graaf, J. de; Holewijn, S.; Folkersen, L.; Franco-Cereceda, A.; Eriksson, P.; Collier, D.A.; Stefansson, H.; Steinthorsdottir, V.; Rafnar, T.; Valdimarsson, E.M.; Magnadottir, H.B.; Sveinbjornsdottir, S.; Olafsson, I.; Magnusson, M.K.; Palmason, R.; Haraldsdottir, V.; Andersen, K.; Onundarson, P.T.; Thorgeirsson, G.; Kiemeney, L.A.L.M.; Powell, J.T.; Carey, D.J.; Kuivaniemi, H.; Lindholt, J.S.; Jones, G.T.; Blankensteijn, J.D.
    In:Nature Genetics, 42, 692 - 697. ISSN 1061-4036.

  • The effect of folinic acid supplementation on homocysteine concentrations in newborns. (2010)

    Authors:Hogeveen, M.; Heijer, M. den; Schonbeck, Y.; IJland, M.M.; Oppenraaij, D. van; Klein Gunnewiek, J.M.T.; Blom, H.J.
    In:European Journal of Clinical Nutrition, 64, 1266 - 1271. ISSN 0954-3007.

    Abstract:

    OBJECTIVE: The incidence of cerebrovascular accidents (CVA) occurring perinatally is relatively high and aspects of the multifactorial pathophysiology remain unclear. Elevated homocysteine concentrations have been shown to be associated with an increased risk for CVA in children and even in newborns

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