Dr.habil. F.J. van der Staay

Pagina-navigatie:

Main
Current research (1)
Publications (44)

filter results

Type

Date

Accessibility

Institution

31-40 out of 44 results by:date

Save search results

Time dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors (2007)

Authors: Rutten, K.; Prickaerts, J.; Hendrix, M.; Staay, van der F.J.; Sik, A.; Blokland, A.
In: European Journal of Pharmacology, 558(1-3), 107 - 112. ISSN 0014-2999.

Abstract:
The present study investigated the time-dependent memory enhancing properties of three selective phosphodiesterase inhibitors (PDE-I) vardenafil (PDE5-I), rolipram (PDE4-I) and BAY 60-7550 (PDE2-I) in the object recognition task. In particular, the time-dependent involvement of cAMP and cGMP in memo
Long-term effects of immunotoxic cholinergic lesions in the septum on acquisition of the cone-field task and noncognitive measures in rats (2006)

Authors: Staay, van der F.J.; Bouger, P.; Lehmann, O.; Lazarus, C.; Cosquer, B.; Koenig, J.; Stump, V.; Cassel, J.C.
In: Hippocampus, 16(12), 1061 - 1079. ISSN 1050-9631.

Abstract:
In rats, nonspecific mechanical or neurotoxic lesions of the septum impair spatial memory in, e.g., Morris water- and radial-maze tasks. Unfortunately, the lack of specificity of such lesions limits inferences about the role of the cholinergic hippocampal projections in spatial cognition. We therefo
Animal models of behavioral dysfunctions: basic concepts and classifications, and an evaluation strategy (2006)

Author: Staay, van der F.J.
In: Brain Research Reviews, 52(1), 131 - 159. ISSN 0165-0173.

Abstract:
In behavioral neurosciences, such as neurobiology and biopsychology, animal models make it possible to investigate brain-behavior relations, with the aim of gaining insight into normal and abnormal human behavior and its underlying neuronal and neuroendocrinological processes. Different types of ani
Two months make a difference in spatial orientation learning in very old hybrid Fischer 344 X Brown Norway (FBNF1) rats (2006)

Author: Staay, van der F.J.
In: Physiology and Behavior, 87(4), 659 - 665. ISSN 0031-9384.

Abstract:
Age-related changes in cognitive performance may be more pronounced in the period near or exceeding the median life span. Therefore, we compared the acquisition of a Morris water escape task by two groups of very old Fischer344 × Brown Norway hybrid rats. The mean age difference between the two grou
Dissociable effects of acetylcholinesterase inhibitors and phosphodiesterase type 5 inhibitors on object recognition memory: acquisition versus consolidation (2005)Open access

Authors: Prickaerts, L.; Sik, A.; Staay, van der F.J.; Vente, de J.; Blokland, A.
In: Psychopharmacology, 177(4), 381 - 390. ISSN 0033-3158.

Abstract:
Rationale Phosphodiesterase enzyme type 5 (PDE5) inhibitors and acetylcholinesterase (AChE) inhibitors have cognition-enhancing properties. However, it is not known whether these drug classes affect the same memory processes. Objective We investigated the memory-enhancing effects of the PDE5 inhib
Absence of long-term behavioral effects after sub-chronic administration of low doses of Methamidophos in male and female rats (2005)

Authors: Temerowski, M.; Staay, van der F.J.
In: Neurotoxicology and Teratology, 27(2), 279 - 297. ISSN 0892-0362.

Abstract:
Putative long-term learning and memory effects of low-dose exposure to the cholinesterase inhibitor organophosphate methamidophos (Tamaron®) early in life were studied in two parallel studies in middle-aged rats. Methamidophos was administered via the drinking water to female and male Wistar rats us
Effects of the cholinestrerase inhibitors donepezil and metrifonate on scopolamine-induced impairments in the spatial cone field orientation task in rats (2005)

Authors: Staay, van der F.J.; Bouger, P.C.
In: Behavioural Brain Research, 156(1), 1 - 10. ISSN 0166-4328.

Abstract:
The aim of these experiments was to assess whether the clinically validated cognition enhancers donepezil (Aricept™, E2020) and metrifonate antagonize scopolamine-induced deficits in the cone field, a complex spatial discrimination task. The cone field task allows measurement of the effects of exper
Spatial discrimination deficits by excitotoxic lesions in the MORRIS WATER ESCAPE TASK (2005)

Authors: Spowart-Manning, L.; Staay, van der F.J.
In: Behavioural Brain Research, 156(2), 269 - 279. ISSN 0166-4328.

Abstract:
The effects of the cholinesterase inhibitors (ChEI) metrifonate and donepezil were assessed on spatial performance of rats with bilateral lesions of the entorhinal cortex (EC), which is thought to model early changes in the brains of patients suffering from Alzheimer's disease. In the present study,
Rats with scopolamine- or MK-801-induced spatial discrimination deficits in the cone field task: animal models for impaired spatial orientation performance (2005)

Authors: Bouger, P.C.; Staay, van der F.J.
In: European Neuropsychopharmacology, 15(3), 331 - 346. ISSN 0924-977x.

Abstract:
Spatial cognition appears to be compromised in elderly and in patients suffering from dementia. These deficits are believed to be modelled, at least partly, by the administration of scopolamine or MK-801 in normal adult animals. In order to establish an animal model suited for the evaluation of puta

Authors:	Rutten, K.; Prickaerts, J.; Hendrix, M.; Staay, van der F.J.; Sik, A.; Blokland, A.
In:	European Journal of Pharmacology, 558(1-3), 107 - 112. ISSN 0014-2999.

Authors:	Staay, van der F.J.; Bouger, P.; Lehmann, O.; Lazarus, C.; Cosquer, B.; Koenig, J.; Stump, V.; Cassel, J.C.
In:	Hippocampus, 16(12), 1061 - 1079. ISSN 1050-9631.

Author:	Staay, van der F.J.
In:	Brain Research Reviews, 52(1), 131 - 159. ISSN 0165-0173.

Author:	Staay, van der F.J.
In:	Physiology and Behavior, 87(4), 659 - 665. ISSN 0031-9384.

Authors:	Prickaerts, L.; Sik, A.; Staay, van der F.J.; Vente, de J.; Blokland, A.
In:	Psychopharmacology, 177(4), 381 - 390. ISSN 0033-3158.

Authors:	Temerowski, M.; Staay, van der F.J.
In:	Neurotoxicology and Teratology, 27(2), 279 - 297. ISSN 0892-0362.

Authors:	Staay, van der F.J.; Bouger, P.C.
In:	Behavioural Brain Research, 156(1), 1 - 10. ISSN 0166-4328.

Authors:	Spowart-Manning, L.; Staay, van der F.J.
In:	Behavioural Brain Research, 156(2), 269 - 279. ISSN 0166-4328.

Authors:	Bouger, P.C.; Staay, van der F.J.
In:	European Neuropsychopharmacology, 15(3), 331 - 346. ISSN 0924-977x.

Phosphodiesterase type 5 inhibition improves early memory consolidation of object information (2004)

Authors:	Prickaerts, J.; Sik, A.; Staveren, van W.; Koopmans, G.; Steinbusch, H.W.M.; Staay, van der F.J.; Vente, de J.; Blokland, A.
In:	Neurochemistry International, 45(6), 915 - 928. ISSN 0197-0186.

Abstract:

The nitric oxide (NO)-cyclic GMP (cGMP) signaling pathway is assumed to play an important role in processes underlying learning and memory. We used phosphodiesterase type 5 (PDE5) inhibitors to study the role of cGMP in object- and spatial memory. Our results and those reported in other studies indi

Pages:

< 1 2 3 4 5 >