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Dr. R.J. van Klaveren

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  • A new ultrafast and high-throughput mass spectrometric approach for the therapeutic drug monitoring of the multi-targeted anti-folate pemetrexed in plasma from lung cancer patients (2010)Open access

    Authors:Meesters, R.J.W. (Roland); Cornelissen, R. (Robin); Klaveren, van R.J. (Rob); Jonge, de R. (Robert); Boer, den E. (Ethan); Lindemans, J. (Jan); Luider, T.M. (Theo)
    In:Analytical and Bioanalytical Chemistry, 398(7-8), 2943 - 2948. ISSN 1618-2642.

    Abstract:

    An analytical assay has been developed and validated for ultrafast and high-throughput mass spectrometric determination of pemetrexed concentrations in plasma using matrix assisted laser desorption/ionization-triple quadrupole-tandem mass spectrometry. Patient plasma samples spiked with the internal

  • A randomized phase II study comparing two schedules of the 21-day regimen of gemcitabine and carboplatin in advanced non-small cell lung cancer (2010)Open access

    Authors:Surmont, V.; Aerts, J.G.J.V. (Joachim); Klaveren, van R.J. (Rob); Tournoy, K.; Tan, K.Y.; Vernhout, R.; Schmitz, P.I.M. (Paul); Legrand, C.; Hoogsteden, H.C. (Henk); Meerbeeck, van J.P. (Jan)
    In:Oncology, 78(3-4), 267 - 270. ISSN 0030-2414.

    Abstract:

    Purpose: Carboplatin area under the curve (AUC) 5 ml/min on day 1 with gemcitabine 1,250 mg/m2on day 1 and day 8 is a widely used regimen in advanced non-small cell lung cancer. Grade 3-4 thrombocytopenia and neutropenia are frequent. The aim of this study is to investigate whether toxicity of gemci

  • Screening for lung cancer with digital chest radiography: Sensitivity and number of secondary work-up CT examinations (2010)

    Authors:Hoop, de B. (Bartjan); Schaefer-Prokop, C. (Cornelia); Gietema, H.A.; Jong, de P.A. (Pim); Ginneken, van B.T.J. (Berbke); Klaveren, van R.J. (Rob); Prokop, M. (Mathias)
    In:Radiology, 255(2), 629 - 637. ISSN 0033-8419.

    Abstract:

    Purpose: To estimate the performance of digital chest radiography for detection of lung cancer. Materials and Methods: The study had ethics committee approval, and a nested case-control design was used and included 55 patients with lung cancer detected at computed tomography (CT) and confirmed with

  • Pulmonary ground-glass nodules: Increase in mass as an early indicator of growth (2010)

    Authors:Hoop, de B. (Bartjan); Gietema, H.A.; Vorst, van de S. (Saskia); Murphy, K. (Keelin); Klaveren, van R.J. (Rob); Prokop, M. (Mathias)
    In:Radiology, 255(1), 199 - 206. ISSN 0033-8419.

    Abstract:

    Purpose: To compare manual measurements of diameter, volume, and mass of pulmonary ground-glass nodules (GGNs) to establish which method is best for identifying malignant GGNs by determining change across time. Materials and Methods: In this ethics committee - approved retrospective study, baseline

  • Pulmonary ground-glass nodules: Increase in mass as an early indicator of growth (2010)

    Authors:Hoop, de B. (Bartjan); Gietema, H.A.; Vorst, van de S. (Saskia); Murphy, K. (Keelin); Klaveren, van R.J. (Rob); Prokop, M. (Mathias)
    In:Radiology, 255(1), 199 - 206. ISSN 0033-8419.

    Abstract:

    Purpose: To compare manual measurements of diameter, volume, and mass of pulmonary ground-glass nodules (GGNs) to establish which method is best for identifying malignant GGNs by determining change across time. Materials and Methods: In this ethics committee - approved retrospective study, baseline

  • Volumetric measurement of pulmonary nodules at low-dose chest CT: Effect of reconstruction setting on measurement variability (2010)Open access

    Authors:Wang, C. (Cathy); Bock, de G.H. (Geertruida); Klaveren, van R.J. (Rob); Ooyen, van P. (Peter); Tukker, W. (Wim); Zhao, Y. (Yingru); Dorrius, M.D. (Monique); Proença, R.V.; Post, W.J. (Wendy); Oudkerk, M. (Matthijs)
    In:European Radiology: journal of the European Congress of Radiology, 20(5), 1180 - 1187. ISSN 0938-7994.

    Abstract:

    Objective: To assess volumetric measurement variability in pulmonary nodules detected at low-dose chest CT with three reconstruction settings. Methods: The volume of 200 solid pulmonary nodules was measured three times using commercially available semi-automated software of low-dose chest CT data-se

  • Short-term health-related quality of life consequences in a lung cancer CT screening trial (NELSON) (2010)

    Authors:Bergh, van den K. (Karien); Essink-Bot, M.L. (Marie-Louise); Borsboom, G.J.J.M. (Gerard); Th Scholten, E.; Prokop, M. (Mathias); Koning, de H.J. (Harry); Klaveren, van R.J. (Rob)
    In:British Journal of Cancer, 102(1), 27 - 34. ISSN 0007-0920.

    Abstract:

    Background: In lung cancer CT screening, participants often have an indeterminate screening result at baseline requiring a follow-up CT. In subjects with either an indeterminate or a negative result after screening, we investigated whether health-related quality of life (HRQoL) changed over time and

  • The authors reply (2010)

    Authors:Klaveren, van R.J. (Rob); Oudkerk, M. (Matthijs); Koning, de H.J. (Harry)
    In:New England Journal of Medicine, 362(8), 758 - 759. ISSN 0028-4793.

  • Management of lung nodules detected by volume CT scanning (2009)

    Authors:Klaveren, van R.J. (Rob); Oudkerk, M. (Matthijs); Prokop, M. (Mathias); Scholten, E.T. (Ernst); Nackaerts, K.; Vernhout, R.; Iersel, van C.A. (Carola); Bergh, van den K. (Karien); Westeinde, van 't S.C. (Susan); Aalst, van der C.M. (Carlijn); Thunnissen, E. (Erik); Xu, D.M.; Wang, Y. (Yongqian); Zhao, Y. (Yingru); Gietema, H.A.; Hoop, de B.J.; Groen, H.J.M. (Henk); Bock, de G.H. (Geertruida); Ooijen, van P.M.A. (Peter); Weenink, C. (Carla); Verschakelen, J. (Johny); Lammers, J.W.J.; Timens, W. (Wim); Willebrand, D. (Dik); Vink, A. (Ard); Mali, W.P. (Willem); Koning, de H.J. (Harry)
    In:New England Journal of Medicine, 361(23), 2221 - 2229. ISSN 0028-4793.

    Abstract:

    BACKGROUND: The use of multidetector computed tomography (CT) in lung-cancer screening trials involving subjects with an increased risk of lung cancer has highlighted the problem for the clinician of deciding on the best course of action when noncalcified pulmonary nodules are detected by CT. METHOD

  • Impact of computed tomography screening for lung cancer on participants in a randomized controlled trial (NELSON trial) (2008)

    Authors:Bergh, van den K. (Karien); Essink-Bot, M-L. (Marie-Louise); Bunge, E.M. (Eveline); Scholten, E.T. (Ernst); Prokop, M. (Mathias); Iersel, van C.A. (Carola); Klaveren, van R.J. (Rob); Koning, de H.J. (Harry)
    In:Cancer, 113(2), 396 - 404. ISSN 0008-543x.

    Abstract:

    BACKGROUND. Computed tomography (CT) screening is an important new tool for the early detection of lung cancer. In the current study, the authors assessed the discomfort associated with CT scanning and the subsequent wait for results and health-related quality of life (HRQoL) over time. METHODS. A t

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