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Dr.ir. M. de Jong

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  • Facilitating tumor functional assessment by spatially relating 3D tumor histology and In Vivo MRI: Image registration approach (2011)Open access

    Authors:Alic, L. (Lejla); Haeck, J.C. (Joost); Bol, K. (Karin); Klein, S. (Stefan); Tiel, van S.T. (Sandra); Wielepolski, P.A. (Piotr); Jong, de M. (Marion); Niessen, W.J. (Wiro); Bernsen, M.R. (Monique); Veenland, J.F. (Jifke)
    In:PLoS ONE, 6(8). ISSN 1932-6203.

    Abstract:

    Background: Magnetic resonance imaging (MRI), together with histology, is widely used to diagnose and to monitor treatment in oncology. Spatial correspondence between these modalities provides information about the ability of MRI to characterize cancerous tissue. However, registration is complicated

  • Preclinical animal research on therapy dosimetry with dual isotopes (2011)Open access

    Authors:Konijnenberg, M.W. (Mark); Jong, de M. (Marion)
    In:European Journal of Nuclear Medicine and Molecular Imaging, 38(SUPPL. 1), 19 - 27. ISSN 1619-7070.

    Abstract:

    Preclinical research into radionuclide therapies based on radiation dosimetry will enable the use of any LET-equivalent radionuclide. Radiation dose and dose rate have significant influence on dose effects in the tumour depending on its radiation sensitivity, possibilities for repair of sublethal da

  • Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice (2011)Open access

    Authors:Vegt, E. (Erik); Melis, M.L. (Marleen); Eek, A. (Annemarie); Visser, de M. (Monique); Brom, M. (Maarten); Oyen, W.J. (Wim); Gotthardt, M. (Martin); Jong, de M. (Marion); Boerman, O.C. (Otto)
    In:European Journal of Nuclear Medicine and Molecular Imaging, 38(4), 623 - 632. ISSN 1619-7070.

    Abstract:

    Purpose: Radiolabelled peptides used for peptide receptor radionuclide therapy are excreted mainly via the kidneys and are partly reabsorbed and retained in the proximal tubular cells. The resulting high renal radiation dose can cause nephrotoxicity, limiting the maximum activity dose and the effect

  • Unfocused Extracorporeal Shock Waves Induce Anabolic Effects in Rat Bone (2011)Open access

    Authors:Jagt, van der O.P. (Olav); Piscaer, T.M. (Tom); Schaden, W. (Wolfgang); Li, J.; Kops, N. (Nic ole); Jahr, H. (Holger); Linden, van der J.C. (Jacqueline); Waarsing, J.H. (Jan); Verhaar, J.A.N. (Jan); Jong, de M. (Marion); Weinans, H.H. (Harrie)
    In:Journal of Bone and Joint Surgery: American Volume, 93(1), 38 - 48. ISSN 0021-9355.

    Abstract:

    Abstract. BACKGROUND: Extracorporeal shock waves are known to stimulate the differentiation of mesenchymal stem cells toward osteoprogenitors and induce the expression of osteogenic-related growth hormones. The aim of this study was to investigate if and how extracorporeal shock waves affected new b

  • Renal toxicity of radiolabeled peptides and antibody fragments: Mechanisms, impact on radionuclide therapy, and strategies for prevention (2010)

    Authors:Vegt, E. (Erik); Jong, de M. (Marion); Wetzels, J.F.M. (Jack); Masereeuw, R. (Rosalinde); Melis, M.L. (Marleen); Oyen, W.J. (Wim); Gotthardt, M. (Martin); Boerman, O.C. (Otto)
    In:The Journal of Nuclear Medicine, 51(7), 1049 - 1058. ISSN 0161-5505.

    Abstract:

    Peptide-receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs such as octreotide is an effective therapy against neuroendocrine tumors. Other radiolabeled peptides and antibody fragments are under investigation. Most of these compounds are cleared through the kidneys and reabso

  • Androgen-regulated gastrin-releasing peptide receptor expression in androgen-dependent human prostate tumor xenografts (2010)Open access

    Authors:Schroeder, R.P.J. (Rogier); Visser, de M. (Monique); Weerden, van W.M. (Wytske); Ridder, C.M.A. (Corrina); Reneman, S. (Suzanne); Melis, M.L. (Marleen); Breeman, W.A.P. (Wouter); Krenning, E.P. (Eric); Jong, de M. (Marion)
    In:International Journal of Cancer, 126(12), 2826 - 2834. ISSN 0020-7136.

    Abstract:

    Human prostate cancer (PC) overexpresses the gastrin-releasing peptide receptor (GRPR). Radiolabeled GRPR-targeting analogs of bombesin (BN) have successfully been introduced as potential tracers for visualization and treatment of GRPR-overexpressing tumors. A previous study showed GRPR-mediated bin

  • Nephrotoxicity in mice after repeated imaging using 111In- labeled peptides (2010)

    Authors:Melis, M.L. (Marleen); Vegt, E. (Erik); Konijnenberg, M.W. (Mark); Visser, de M. (Monique); Bijster, M. (Magda); Vermeij, M. (Marcel); Krenning, E.P. (Eric); Boerman, O.C. (Otto); Jong, de M. (Marion)
    In:The Journal of Nuclear Medicine, 51(6), 973 - 977. ISSN 0161-5505.

    Abstract:

    We determined the renal radiation dose of a series of111Inlabeled peptides using animal SPECT. Because the animals' health deteriorated, renal toxicity was assessed. Methods: Wild-type and megalin-deficient mice were imaged repeatedly at 3- to 6-wk intervals to quantify renal retention after injecti

  • Of mice and humans: Are they the same? - Implications in cancer translational research (2010)

    Authors:Jong, de M. (Marion); Maina, T. (Theodosia)
    In:The Journal of Nuclear Medicine, 51(4), 501 - 504. ISSN 0161-5505.

    Abstract:

    Animal models have been instrumental in elucidating key biochemical and physiologic processes of cancer onset and propagation in a living organism. Most importantly, they have served as a surrogate for patients in the evaluation of novel diagnostic and therapeutic anticancer drugs, including radioph

  • Albumin-derived peptides efficiently reduce renal uptake of radiolabelled peptides (2010)Open access

    Authors:Vegt, E. (Erik); Eek, A. (Annemarie); Oyen, W.J. (Wim); Jong, de M. (Marion); Gotthardt, M. (Martin); Boerman, O.C. (Otto)
    In:European Journal of Nuclear Medicine and Molecular Imaging, 37(2), 226 - 234. ISSN 1619-7070.

    Abstract:

    Purpose: In peptide-receptor radionuclide therapy (PRRT), the maximum activity dose that can safely be administered is limited by high renal uptake and retention of radiolabelled peptides. The kidney radiation dose can be reduced by coinfusion of agents that competitively inhibit the reabsorption of

  • Peptide receptor imaging of prostate cancer with radiolabelled bombesin analogues (2009)Open access

    Authors:Schroeder, R.P.J. (Rogier); Weerden, van W.M. (Wytske); Bangma, C.H. (Chris); Krenning, E.P. (Eric); Jong, de M. (Marion)
    In:Methods, 48(2), 200 - 204. ISSN 1046-2023.

    Abstract:

    Prostate Cancer (PC) is a type of cancer that is often diagnosed at very early stages due to improved detection among man in the Western world. Current imaging techniques are not optimal to determine extent of minimal early stage PC even though this is of great clinical importance. Human PC and high

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