Dr. B.A. 't Hart

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Erasmus Universiteit Rotterdam (2)

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Late B cell depletion with a human anti-human CD20 IgG1κ monoclonal antibody halts the development of experimental autoimmune encephalomyelitis in marmosets (2010)

Auteurs:	Kap, Y.S. (Yolanda); Driel, van N. (Nikki); Blezer, E. (Erwin); Parren, P.W.H.I. (Paul); Bleeker, W.K. (Wim); Laman, J.D. (Jon); Craigen, J.L. (Jenny); Hart, 't B.A. (Bert)
In:	Journal of Immunology, 185(7), 3990 - 4003. ISSN 0022-1767.

Samenvatting:

Depletion of CD20+B cells has been related to reduced clinical activity in relapsing-remitting multiple sclerosis. The underlying mechanism is not understood, because serum IgG levels were unaltered by the treatment. We report the effect of late B cell depletion on cellular and humoral immune mechan

Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs (2002)Open access

Auteurs:	Vos, de A.F. (Alex); Laman, J.D. (Jon); Meurs, van M. (Marjan); Brok, H.P.M. (Herbert); Boven, L.A. (Leonie); Hintzen, R.Q. (Rogier); Valk, van der P. (Paul); Ravid, R. (Rivka); Rensing, S. (Susanne); Boon, L. (Louis); Hart, 't B.A. (Bert)
In:	Journal of Immunology. ISSN 0022-1767.

Samenvatting:

Dendritic cells are thought to regulate tolerance induction vs immunization by transferring Ags and peripheral signals to draining lymph nodes (LN). However, whether myelin Ag transfer and presentation in LN occurs during demyelinating brain disease is unknown. In this study, we