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Dr. T.M. Luider

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  • Analytical investigations of toxic p-phenylenediamine (PPD) levels in clinical urine samples with special focus on MALDI-MS/MS (2011)Open access

    Authors:Hooff, G.P. (Gero); Huizen, van N.A. (Nick); Meesters, R.J.W. (Roland); Zijlstra, E. (Ed); Abdelraheem, M. (Mohamed); Hamdouk, M. (Mohamed); Lindemans, J. (Jan); Luider, T.M. (Theo)
    In:PLoS ONE, 6(8). ISSN 1932-6203.

    Abstract:

    Para-phenylenediamine (PPD) is a common chromophoric ingredient in oxidative hair-dyes. In some African countries like Sudan, Egypt and Morocco but also in India this chemical is used alone or in combination with colouring extracts like Henna for dyeing of the hair or the skin. Excessive dermal expo

  • Fusion of metabolomics and proteomics data for biomarkers discovery: Case study on the experimental autoimmune encephalomyelitis (2011)

    Authors:Blanchet, L. (Lionel); Smolinska, A. (Agnieszka); Attali, A. (Amos); Stoop, M.P. (Marcel); Ampt, K.A.M. (Kirsten A.M.); Aken, van H. (Hugo); Suidgeest, E. (Ernst); Tuinstra, T. (Tinka); Wijmenga, S.S. (Sybren S.); Luider, T.M. (Theo); Buydens, L.M.C. (Lutgarde M.C.)
    In:B M C Bioinformatics, 12. ISSN 1471-2105.

    Abstract:

    Background: Analysis of Cerebrospinal Fluid (CSF) samples holds great promise to diagnose neurological pathologies and gain insight into the molecular background of these pathologies. Proteomics and metabolomics methods provide invaluable information on the biomolecular content of CSF and thereby on

  • Dried blood spot UHPLC-MS/MS analysis of oseltamivir and oseltamivircarboxylate-a validated assay for the clinic (2011)Open access

    Authors:Hooff, G.P. (Gero); Meesters, R.J.W. (Roland); Kampen, van J.J.A. (Jeroen); Huizen, van N.A. (Nick); Koch, B. (Birgit); Al Hadithy, A.F.Y. (Asmar); Gelder, van T. (Teun); Osterhaus, A.D.M.E. (Ab); Gruters, R.A. (Rob); Luider, T.M. (Theo)
    In:Analytical and Bioanalytical Chemistry, 400, 3473 - 3479. ISSN 1618-2642.

    Abstract:

    The neuraminidase inhibitor oseltamivir (Tamiflu®) is currently the first-line therapy for patients with influenza virus infection. Common analysis of the prodrug and its active metabolite oseltamivircarboxylate is determined via extraction from plasma. Compared with these assays, dried blood spot (

  • Label-free peptide profiling of Orbitrap™ full mass spectra (2011)Open access

    Authors:Titulaer, M.K. (Mark); Costa, de D. (Dominique); Stingl, C. (Christoph); Dekker, L.J.M. (Lennard); Sillevis Smitt, P.A.E. (Peter); Luider, T.M. (Theo)
    In:BMC Research Notes, 4. ISSN 1756-0500.

    Abstract:

    Background. We developed a new version of the open source software package Peptrix that can yet compare large numbers of Orbitrap™ LC-MS data. The peptide profiling results for Peptrix on MS1 spectra were compared with those obtained from a small selection of open source and commercial software pack

  • A new ultrafast and high-throughput mass spectrometric approach for the therapeutic drug monitoring of the multi-targeted anti-folate pemetrexed in plasma from lung cancer patients (2010)Open access

    Authors:Meesters, R.J.W. (Roland); Cornelissen, R. (Robin); Klaveren, van R.J. (Rob); Jonge, de R. (Robert); Boer, den E. (Ethan); Lindemans, J. (Jan); Luider, T.M. (Theo)
    In:Analytical and Bioanalytical Chemistry, 398(7-8), 2943 - 2948. ISSN 1618-2642.

    Abstract:

    An analytical assay has been developed and validated for ultrafast and high-throughput mass spectrometric determination of pemetrexed concentrations in plasma using matrix assisted laser desorption/ionization-triple quadrupole-tandem mass spectrometry. Patient plasma samples spiked with the internal

  • Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis (2010)Open access

    Authors:Stoop, M.P. (Marcel); Singh, V. (Vaibhav); Dekker, L.J.M. (Lennard); Titulaer, M.K. (Mark); Stingl, C. (Christoph); Burgers, P.C. (Peter); Sillevis Smitt, P.A.E. (Peter); Hintzen, R.Q. (Rogier); Luider, T.M. (Theo)
    In:PLoS ONE, 5(8), 1 - 8. ISSN 1932-6203.

    Abstract:

    Background: Based on clinical representation of disease symptoms multiple sclerosis (MScl) patients can be divided into two major subtypes; relapsing remitting (RR) MScl (85-90%) and primary progressive (PP) MScl (10-15%). Proteomics analysis of cerebrospinal fluid (CSF) has detected a number of pro

  • Immune responses are characterized by specific shared immunoglobulin peptides that can be detected by proteomic techniques (2010)

    Authors:VanDuijn, M.M. (Martijn); Dekker, L.J.M. (Lennard); Zeneyedpour, L. (Lona); Sillevis Smitt, P.A.E. (Peter); Luider, T.M. (Theo)
    In:Journal of Biological Chemistry, 285(38), 29247 - 29253. ISSN 0021-9258.

    Abstract:

    In the adaptive immune response, immunoglobulins develop that bind specifically to the antigens to which the organism was exposed. Immunoglobulins may bind to known or unknown antigens in a variety of diseases and have been used in the past to identify novel antigens for use as a biomarker. We propo

  • Ultrafast and high-throughput mass spectrometric assay for therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots (2010)Open access

    Authors:Meesters, R.J.W. (Roland); Kampen, van J.J.A. (Jeroen); Reedijk, M.L. (Mariska); Scheuer, R.D. (Rachel); Dekker, L.J.M. (Lennard); Burger, D.M. (David); Hartwig, N.G. (Nico); Osterhaus, A.D.M.E. (Ab); Luider, T.M. (Theo); Gruters, R.A. (Rob)
    In:Analytical and Bioanalytical Chemistry, 398(1), 319 - 328. ISSN 1618-2642.

    Abstract:

    Kaletra® (Abott Laboratories) is a co-formulated medication used in the treatment of HIV-1-infected children, and it contains the two antiretroviral protease inhibitor drugs lopinavir and ritonavir. We validated two new ultrafast and high-throughput mass spectrometric assays to be used for therapeut

  • Proteomic Analysis of Human Osteoblastic Cells: Relevant Proteins and Functional Categories for Differentiation (2010)Open access

    Authors:Alves, R.D.A.M. (Rodrigo); Eijken, H.J.M. (Marco); Swagemakers, S.M.A. (Sigrid); Chiba, H. (Hideki); Titulaer, M.K. (Mark); Burgers, P.C. (Peter); Luider, T.M. (Theo); Leeuwen, van J.P.T.M. (Hans)
    In:Journal of Proteome Research, 9(9), 4688 - 4700. ISSN 1535-3893.

    Abstract:

    Abstract Osteoblasts are the bone forming cells, capable of secreting an extracellular matrix with mineralization potential. The exact mechanism by which osteoblasts differentiate and form a mineralized extracellular matrix is presently not fully understood. To increase our knowledge about this pro

  • Quantitative proteomics and metabolomics analysis of normal human cerebrospinal fluid samples (2010)

    Authors:Stoop, M.P. (Marcel); Coulier, L. (Leon); Rosenling, T. (Therese); Shi, S. (Shanna); Smolinska, A. (Agnieszka); Buydens, L. (Lutgarde); Ampt, K.A.M. (Kirsten A.M.); Stingl, C. (Christoph); Dane, A. (Adrie); Muilwijk, B. (Bas); Luitwieler, R.L. (Ronald); Sillevis Smitt, P.A.E. (Peter); Hintzen, R.Q. (Rogier); Bischoff, R. (Rainer); Wijmenga, S.S. (Sybren S.); Hankemeier, T. (Thomas); Gool, van A.J. (Alain); Luider, T.M. (Theo)
    In:Molecular and Cellular Proteomics, 9(9), 2063 - 2075. ISSN 1535-9476.

    Abstract:

    The analysis of cerebrospinal fluid (CSF) is used in biomarker discovery studies for various neurodegenerative central nervous system (CNS) disorders. However, little is known about variation of CSF proteins and metabolites between patients without neurological disorders. A baseline for a large numb

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