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Dr. J. van der Vlag Person

Dr. J. van der Vlag

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  • Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking. (2008)

    Authors:Rops, A.L.; Hoven, M.J.W. van den; Baselmans, M.M.; Lensen, J.F.; Wijnhoven, T.J.; Heuvel, L.P.v.d.; Kuppevelt, A.H.M.S.M. van; Berden, J.H.M.; Vlag, J. van der
    In:Kidney International, 73, 52 - 62. ISSN 0085-2538.

    Abstract:

    Heparan sulfate (HS) proteoglycans by playing key roles in the leukocyte-endothelial interactions are thought to mediate inflammatory cell influx in proliferative glomerulonephritis. Here, we evaluated the specific features within glomerular endothelial HS that promote leukocyte adhesion. Mouse and

  • Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy. (2008)

    Authors:Wijnhoven, T.J.; Hoven, M.J.W. van den; Ding, H.; Kuppevelt, A.H.M.S.M. van; Vlag, J. van der; Berden, J.H.M.; Prinz, R.A.; Lewis, E.J.; Schwartz, M.; Xu, X.
    In:Diabetologia, 51, 372 - 382. ISSN 0012-186x.

    Abstract:

    AIMS/HYPOTHESIS: Recent studies suggest that loss of heparan sulphate in the glomerular basement membrane (GBM) of the kidney with diabetic nephropathy is due to the increased production of heparanase, a heparan sulphate-degrading endoglycosidase. Our present study addresses whether heparan sulphate

  • Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus. (2008)

    Authors:Bavel, C.C.A.W. van; Fenton, K.A.; Rekvig, O.P.; Vlag, J. van der; Berden, J.H.M.
    In:Arthritis and Rheumatism, 58, 1892 - 1899. ISSN 0004-3591.

  • Sperm-derived histones contribute to zygotic chromatin in humans. (2008)Open access

    Authors:Heijden, GW van der; Ramos, L.; Baart, E.B.; Berg, IM van den; Derijck, A.A.; Vlag, J. van der; Martini, E.; Boer, P. de
    In:BMC Developmental Biology, 8, 34-1 - 34-6. ISSN 1471-213x.

    Abstract:

    BACKGROUND: about 15% to 30% of the DNA in human sperm is packed in nucleosomes and transmission of this fraction to the embryo potentially serves as a mechanism to facilitate paternal epigenetic programs during embryonic development. However, hitherto it has not been established whether these nucle

  • Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria. (2008)Open access

    Authors:Hoven, M.J.W. van den; Wijnhoven, T.J.; Li, J.P.; Zcharia, E.; Dijkman, H.B.; Wismans, P.G.P.; Rops, A.L.; Lensen, J.F.; Heuvel, L.P.v.d.; Kuppevelt, A.H.M.S.M. van; Vlodavsky, I.; Berden, J.H.M.; Vlag, J. van der
    In:Kidney International, 73, 278 - 287. ISSN 0085-2538.

    Abstract:

    Heparan sulfate in the glomerular basement membrane has been considered crucial for charge-selective filtration. In many proteinuric diseases, increased glomerular expression of heparanase is associated with decreased heparan sulfate. Here, we used mice overexpressing heparanase and evaluated the ex

  • Proteasome inhibition: a new therapeutic option in lupus nephritis? (2008)Open access

    Authors:Vlag, J. van der; Berden, J.H.M.
    In:Nephrology Dialysis Transplantation, 23, 3771 - 3772. ISSN 0931-0509.

  • Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice (2008)

    Authors:Cunningham, R.; Esmaili, A.; Brown, E.; Biswas, R.S.; Murtazina, R.; Donowitz, M.; Dijkman, H.B.; Vlag, J. van der; Hogema, B.M.; Jonge, H.R. de; Shenolikar, S.; Wade, J.B.; Weinman, E.J.
    In:American Journal of Physiology : Renal Physiology, 294, F1001 - F1007. ISSN 0363-6127.

    Abstract:

    The adaptor proteins sodium/hydrogen exchanger regulatory factor (NHERF)-1 and NHERF-2 have overlapping tissue distribution in renal cells and overlapping specificity in their binding to renal transporters and other proteins. To compare the kidney-specific differences in the function of these adapto

  • Apoptosis-linked changes in the phosphorylation status and subcellular localization of the spliceosomal autoantigen U1-70K. (2008)

    Authors:Dieker, J.; Cisterna, B.; Monneaux, F.; Decossas, M.; Vlag, J. van der; Biggiogera, M.; Muller, S.
    In:Cell Death and Differentiation, 15, 793 - 804. ISSN 1350-9047.

    Abstract:

    Apoptosis consists of highly regulated pathways involving post-translational modifications and cleavage of proteins leading to sequential inactivation of the main cellular processes. Here, we focused on the apoptotic processing of one of the essential components of the mRNA splicing machinery, the U

  • Are primed polymorphonuclear leukocytes contributors to the high heparanase levels in hemodialysis patients? (2008)

    Authors:Cohen-Mazor, M.; Sela, S.; Mazor, R.; Ilan, N.; Vlodavsky, I.; Rops, A.L.; Vlag, J. van der; Cohen, H.I.; Kristal, B.
    In:American Journal of Physiology : Heart and Circulatory Physiology, 294, H651 - H658. ISSN 0363-6135.

    Abstract:

    Patients on chronic hemodialysis (HD) are at high risk for developing atherosclerosis and cardiovascular complications. Heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is involved in extracellular matrix degradation and, as such, may be involved in the

  • Removal of heparan sulfate from the glomerular basement membrane blocks protein passage. (2008)Open access

    Authors:Wijnhoven, T.J.M.; Lensen, J.F.M.; Wismans, R.G.; Lefeber, D.J.; Rops, A.; Vlag, J. van der; Berden, J.H.M.; Kuppevelt, A.H.M.S.M. van
    In:Journal of the American Society of Nephrology, 19, 647 - 647. ISSN 1046-6673.

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