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Prof.dr. A. Hofman Person

Prof.dr. A. Hofman

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  • Genetic variants associated with cardiac structure and function: A meta-analysis and replication of genome-wide association data (2009)

    Authors:Vasan, R.S. (Ramachandran Srini); Glazer, N.L. (Nicole); Felix, J.F. (Janine); Lieb, W. (Wolfgang); Wild, P.S. (Philipp); Watzinger, N. (Norbert); Larson, M.G. (Martin); Smith, N.L. (Nicholas); Dehghan, A. (Abbas); Großhennig, A. (Anika); Schillert, A. (Arne); Teumer, A. (Alexander); Schmidt, R. (Reinhold); Kathiresan, S. (Sekar); Lumley, T. (Thomas); Aulchenko, Y.S. (Yurii); König, I.R. (Inke); Zeller, T. (Tanja); Homuth, G. (Georg); Struchalin, M.V. (Maksim); Aragam, J. (Jayashri); Bis, J.C. (Joshua); Rivadeneira Ramirez, F. (Fernando); Erdmann, J. (Jeanette); Schnabel, R. (Renate); Dörr, M. (Marcus); Zweiker, R. (Robert); Lind, L. (Lars); Rodeheffer, R.J. (Richard); Greiser, K.H. (Karin Halina); Levy, D. (Daniel); Haritunians, T. (Talin); Deckers, J.W. (Jaap); Stritzke, J. (Jan); Lackner, K.J. (Karl); Völker, U. (Uwe); Ingelsson, E. (Erik); Kullo, I. (Iftikhar); Haerting, J. (Johannes); Heckbert, S.R. (Susan); Stricker, B.H.Ch. (Bruno); Ziegler, A. (Andreas); Reffelmann, T. (Thorsten); Redfield, M.M. (Margaret); Werdan, K. (Karl); Mitchell, G.F. (Gary); Rice, K. (Kenneth); Arnett, D.K. (Donna); Hofman, A. (Albert); Gottdiener, J.S. (John); Uitterlinden, A.G. (André); Meitinger, T. (Thomas); Blettner, M. (Maria); Friedrich, N. (Nele); Wang, T.J. (Thomas); Psaty, B.M. (Bruce); Tikka-Kleemola, P. (Päivi); Wichmann, H.E. (Erich); Munzel, T. (Thomas); Kroemer, H.K. (Heyo); Benjamin, E.J. (Emelia); Rotter, J.I. (Jerome); Witteman, J.C.M. (Jacqueline); Schunkert, H. (Heribert); Völzke, H. (Henry); Blankenberg, S. (Stefan); O'Donnell, C.J. (Christopher)
    In:J A M A: The Journal of the American Medical Association, 302(2), 168 - 178. ISSN 0098-7484.

    Abstract:

    Context: Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease. Objective: To identify common genetic variants associated with cardiac structure and function by conducting a meta-analysis of genome-wide association data in 5 pop

  • Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution (2009)Open access

    Authors:Lindgren, C.M. (Cecilia); Heid, I.M. (Iris); Randall, J.C. (Joshua); Lamina, C. (Claudia); Steinthorsdottir, V. (Valgerdur); Qi, L. (Lu); Speliotes, E.K. (Elizabeth); Thorleifsson, G. (Gudmar); Willer, C.J. (Cristen); Herrera, B.M. (Blanca); Jackson, A.U. (Anne); Lim, N. (Noha); Scheet, P. (Paul); Soranzo, N. (Nicole); Amin, N. (Najaf); Aulchenko, Y.S. (Yurii); Chambers, J.C. (John); Drong, A. (Alexander); Luan, J.; Lyon, H.N. (Helen); Rivadeneira Ramirez, F. (Fernando); Sanna, S.; Timpson, N. (Nicholas); Zillikens, M.C. (Carola); Jing, H.Z.; Almgren, P. (Peter); Bandinelli, S. (Stefania); Bennett, A.J. (Amanda); Bergman, R.N. (Richard); Bonnycastle, L.L. (Lori); Bumpstead, S. (Suzannah); Chanock, S.J. (Stephen); Cherkas, L. (Lynn); Chines, P.S. (Peter); Coin, L. (Lachlan); Cooper, C. (Charles); Crawford, G. (Gabe); Doering, A. (Angela); Dominiczak, A. (Anna); Doney, A.S.F. (Alex); Ebrahim, S. (Shah); Elliott, P. (Paul); Erdos, M.R. (Michael); Estrada, K. (Karol); Ferrucci, L. (Luigi); Fischer, G. (Guido); Forouhi, N.G. (Nita); Gieger, C. (Christian); Grallert, H. (Harald); Groves, C.J. (Christopher); Grundy, S.M. (Scott); Guiducci, C. (Candace); Hadley, D. (David); Hamsten, A. (Anders); Havulinna, A.S. (Aki); Hofman, A. (Albert); Holle, R. (Rolf); Holloway, J.W. (John); Illig, T. (Thomas); Isomaa, B. (Bo); Jacobs, L.C. (Leonie); Jameson, K. (Karen); Jousilahti, P. (Pekka); Karpe, F. (Fredrik); Kuusisto, J. (Johanna); Laitinen, J. (Jaana); Lathrop, G.M. (Mark); Lawlor, D.A. (Debbie); Mangino, M. (Massimo); McArdle, W.L. (Wendy); Meitinger, T. (Thomas); Morken, M.A. (Mario); Morris, A.P. (Andrew); Munroe, P. (Patricia); Narisu, N. (Narisu); Nordström, A. (Anna); Oostra, B.A. (Ben); Palmer, C.N.A. (Colin); Payne, F. (Felicity); Peden, J. (John); Prokopenko, I. (Inga); Renström, F. (Frida); Ruokonen, A. (Aimo); Salomaa, V. (Veikko); Sandhu, M.S. (Manjinder); Scott, L.J. (Laura); Scuteri, A. (Angelo); Silander, K. (Kaisa); Song, K. (Kijoung); Yuan, X. (Xin); Stringham, H.M. (Heather); Swift, A.J. (Amy); Tuomi, T. (Tiinamaija); Uda, M.; Vollenweider, P. (Peter); Waeber, G. (Gérard); Wallace, C. (Chris); Walters, G.B. (Bragi); Weedon, M.N. (Michael); Witteman, J.C.M. (Jacqueline); Zhang, C. (Cuilin); Caulfield, M. (Mark); Collins, F.S. (Francis); Smith, G.D.; Day, I.N.M. (Ian); Franks, P.W. (Paul); Hattersley, A.T. (Andrew); Hu, F.B. (Frank); Jarvelin, M.R.; Kong, A. (Augustine); Kooner, J.S. (Jaspal); Laakso, M. (Markku); Lakatta, E. (Edward); Mooser, V. (Vincent); Peltonen, L. (Leena Johanna); Samani, N.J. (Nilesh); Spector, T.D. (Timothy); Strachan, D.P. (David); Tanaka, T. (Toshiko); Tuomilehto, J. (Jaakko); Uitterlinden, A.G. (André); Tikka-Kleemola, P. (Päivi); Wareham, N.J. (Nicholas); Watkins, H. (Hugh); Waterworth, D. (Dawn); Boehnke, M. (Michael); Deloukas, P. (Panagiotis); Groop, L. (Leif); Hunter, D.J. (David); Thorsteinsdottir, U. (Unnur); Schlessinger, D. (David); Wichmann, H.E. (Erich); Frayling, T.M. (Timothy); Abecasis, G.R. (Goncala); Hirschhorn, J.N. (Joel); Loos, R.J.F. (Ruth); Zwart, J-A. (John-Anker); Mohlke, K.L. (Karen); Barroso, I. (Inês); McCarthy, M.I. (Mark)
    In:P L o S Genetics (Print), 5(6). ISSN 1553-7390.

    Abstract:

    To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of asso

  • NRXN3Is a novel locus for waist circumference: A genome-wide association study from the CHARGE consortium (2009)Open access

    Authors:Heard-Costa, N.L. (Nancy); Zillikens, M.C. (Carola); Monda, K.L. (Keri); Johansson, A. (Åsa); Harris, T.B. (Tamara); Fu, M. (Mao); Haritunians, T. (Talin); Feitosa, M.F. (Mary Furlan); Aspelund, T. (Thor); Eiriksdottir, G. (Gudny); Garcia, M. (Melissa); Launer, L.J. (Lenore); Smith, A.V. (Albert Vernon); Mitchell, B.D. (Braxton); McArdle, P.F. (Patrick); Shuldiner, A.R. (Alan); Bielinski, S.J. (Suzette); Boerwinkle, E. (Eric); Brancati, F. (Fred); Demerath, E.W. (Ellen); Pankow, J.S. (James); Arnold, A.M. (Alice); Chen, Y.D.I.; Glazer, N.L. (Nicole); McKnight, B. (Barbara); Psaty, B.M. (Bruce); Rotter, J.I. (Jerome); Amin, N. (Najaf); Campbell, H. (Harry); Gyllensten, U. (Ulf); Pattaro, C. (Cristian); Pramstaller, P.P. (Peter Paul); Rudan, I. (Igor); Struchalin, M.V. (Maksim); Vitart, V. (Veronique); Gao, X. (Xiaoyi); Kraja, A. (Aldi); Province, M.A. (Mike); Zhang, Q. (Qunyuan); Atwood, L.D. (Larry); Dupuis, J. (Josée); Hirschhorn, J.N. (Joel); Jaquish, C.E. (Cashell); Vasan, R.S. (Ramachandran Srini); White, C.C. (Charles); Aulchenko, Y.S. (Yurii); Estrada Gil, K. (Karol); Hofman, A. (Albert); Rivadeneira Ramirez, F. (Fernando); Uitterlinden, A.G. (André); Witteman, J.C.M. (Jacqueline); Oostra, B.A. (Ben); Kaplan, R.C. (Robert); Gudnason, V. (Vilmundur); O'Donnell, C.J. (Christopher); O´Connell, J.R.; Borecki, I.B. (Ingrid); Duijn, van C.M. (Cock); Cupples, L.A. (Adrienne); Fox, C.S. (Caroline); North, K.E. (Kari)
    In:P L o S Genetics (Print), 5(6). ISSN 1553-7390.

    Abstract:

    Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist circumference (WC). In total, three loci reached genome-wide significance. In stag

  • Explaining educational inequalities in birthweight: The Generation R Study (2009)Open access

    Authors:Jansen, P.W. (Pauline); Tiemeier, H. (Henning); Looman, C.W.N. (Caspar); Jaddoe, V.W.V. (Vincent); Hofman, A. (Albert); Moll, H.A. (Henriëtte); Steegers, E.A.P. (Eric); Verhulst, F.C. (Frank); Mackenbach, J.P. (Johan); Raat, H. (Hein)
    In:Paediatric and Perinatal Epidemiology (Print), 23(3), 216 - 228. ISSN 0269-5022.

    Abstract:

    Although low socio-economic status has consistently been associated with lower birthweight, little is known about the factors whereby socio-economic disadvantage influences birthweight. We therefore examined explanatory mechanisms that may underlie the association between the educational level of pr

  • Genomewide association studies of stroke (2009)Open access

    Authors:Ikram, M.A. (Mohammed Arfan); Seshadri, S. (Sudha); Bis, J.C. (Joshua); Fornage, M. (Myriam); DeStefano, A.L. (Anita); Aulchenko, Y.S. (Yurii); Debette, S. (Stéphanie); Lumley, T. (Thomas); Folsom, A.R. (Aaron); Herik, van den E.G. (Evita); Bos, M.J. (Michiel); Beiser, A. (Alexa); Cushman, M. (Mary Ann); Launer, L.J. (Lenore); Shahar, E. (Eyal); Struchalin, M.V. (Maksim); Du, Y. (Yangchun); Glazer, N.L. (Nicole); Rosamond, W.D. (Wayne); Rivadeneira Ramirez, F. (Fernando); Kelly-Hayes, M. (Margaret); Lopez, O.L. (Oscar); Coresh, J. (Josef); Hofman, A. (Albert); DeCarli, C. (Charles); Heckbert, S.R. (Susan); Koudstaal, P.J. (Peter); Yang, Q. (Qiong Fang); Smith, N.L. (Nicholas); Kase, C.S. (Carlos); Rice, K. (Kenneth); Haritunians, T. (Talin); Forey, F.; Kort, de P.L.M.; Taylor, K.D. (Kent); Lau, de L.M.L. (Lonneke); Oostra, B.A. (Ben); Uitterlinden, A.G. (André); Rotter, J.I. (Jerome); Boerwinkle, E. (Eric); Psaty, B.M. (Bruce); Mosley, T.H. (Thomas); Duijn, van C.M. (Cock); Breteler, M.M.B. (Monique); Longstreth, W.T.; Wolf, P.A. (Philip)
    In:New England Journal of Medicine, 360(17), 1718 - 1728. ISSN 0028-4793.

    Abstract:

    BACKGROUND: The genes underlying the risk of stroke in the general population remain undetermined. METHODS: We carried out an analysis of genomewide association data generated from four large cohorts composing the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, including 19,

  • Maternal Psychopathology Influences Infant Heart Rate Variability: Generation R Study (2009)Open access

    Authors:Dierckx, B. (Bram); Tulen, J.H.M. (Joke); Lambregtse-van den Berg, M.P. (Mijke); Tharner, A. (Anne); Jaddoe, V.W.V. (Vincent); Moll, H.A. (Henriëtte); Hofman, A. (Albert); Verhulst, F.C. (Frank); Tiemeier, H. (Henning)
    In:Psychosomatic Medicine, 71(3), 313 - 321. ISSN 0033-3174.

    Abstract:

    Abstract OBJECTIVE: To assess the determinants of heart rate (HR) and heart rate variability (HRV) in children. The autonomic nervous system as measured by HR and HRV is considered a biological marker of psychopathology in children. METHODS: We examined the relationship of maternal psychopathology

  • Meta-analysis of genome-wide scans for human adult stature identifies novel loci and associations with measures of skeletal frame size (2009)Open access

    Authors:Soranzo, N. (Nicole); Rivadeneira Ramirez, F. (Fernando); Chinappen-Horsley, U. (Usha); Malkina, I. (Ida); Richards, J.B. (Brent); Hammond, N. (Naomi); Stolk, L. (Lisette); Nica, A. (Alexandra); Inouye, M. (Michael); Hofman, A. (Albert); Stephens, J. (Jonathan); Wheeler, E. (Eleanor); Arp, P.P. (Pascal); Gwilliam, R. (Rhian); Jhamai, P.M. (Mila); Potter, S. (Simon); Chaney, A. (Amy); Ghori, M.J.R. (Mohammed); Ravindrarajah, R. (Radhi); Ermakov, S. (Sergey); Estrada Gil, K. (Karol); Pols, H.A.P. (Huib); Williams, F.M. (Frances); McArdle, W.L. (Wendy); Meurs, van J.B.J. (Joyce); Loos, R.J.F. (Ruth); Frants, R.R. (Rune); Ahmadi, K.R. (Kourosh); Hart, D.J. (Deborah); Ouwehand, W.H. (Willem); Wareham, N.J. (Nicholas); Barroso, I. (Inês); Sandhu, M.S. (Manjinder); Strachan, D.P. (David); Demissie, S. (Serkalem); Livshits, G. (Gregory); Spector, T.D. (Timothy); Uitterlinden, A.G. (André)
    In:P L o S Genetics (Print), 5(4). ISSN 1553-7390.

    Abstract:

    Recent genome-wide (GW) scans have identified several independent loci affecting human stature, but their contribution through the different skeletal components of height is still poorly understood. We carried out a genome-wide scan in 12,611 participants, followed by replication in an additional 7,

  • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation (2009)

    Authors:Willer, C.J. (Cristen); Speliotes, E.K. (Elizabeth); Loos, R.J.F. (Ruth); Li, S. (Shengxu); Lindgren, C.M. (Cecilia); Heid, I.M. (Iris); Berndt, S.I. (Sonja); Elliott, A.L. (Amanda); Jackson, A.U. (Anne); Lamina, C. (Claudia); Lettre, G. (Guillaume); Lim, N. (Noha); Lyon, H.N. (Helen); McCarroll, S.A. (Steven); Papadakis, K. (Konstantinos); Qi, L. (Lu); Randall, J.C. (Joshua); Roccasecca, R.M.; Sanna, S.; Scheet, P. (Paul); Weedon, M.N. (Michael); Wheeler, E. (Eleanor); Zhao, J.H.; Jacobs, L.C. (Leonie); Prokopenko, I. (Inga); Soranzo, N. (Nicole); Tanaka, T. (Toshiko); Timpson, N. (Nicholas); Almgren, P. (Peter); Bennett, A.J. (Amanda); Bergman, R.N. (Richard); Bingham, S. (Sheila); Bonnycastle, L.L. (Lori); Brown, M.J. (Morris); Burtt, N.P. (Noël); Chines, P.S. (Peter); Coin, L. (Lachlan); Collins, F.S. (Francis); Connell, J. (John); Cooper, C. (Charles); Smith, G.D.; Dennison, E.M. (Elaine); Deodhar, P. (Parimal); Erdos, M.R. (Michael); Estrada Gil, K. (Karol); Evans, D.M. (David); Gianniny, L. (Lauren); Gieger, C. (Christian); Gillson, C.J. (Christopher); Guiducci, C. (Candace); Hackett, R. (Rachel); Hadley, D. (David); Hall, A.S. (Alistair); Havulinna, A.S. (Aki); Hebebrand, J. (Johannes); Hofman, A. (Albert); Isomaa, B. (Bo); Johnson, T. (Toby); Jousilahti, P. (Pekka); Jovanovic, Z. (Zorica); Khaw, K-T. (Kay-Tee); Kraft, P. (Peter); Kuokkanen, M. (Mikko); Kuusisto, J. (Johanna); Laitinen, J. (Jaana); Lakatta, E. (Edward); Luan, J.; Luben, R.N. (Robert); Mangino, M. (Massimo); McArdle, W.L. (Wendy); Meitinger, T. (Thomas); Mulas, A. (Antonella); Munroe, P. (Patricia); Narisu, N. (Narisu); Ness, A.R. (Andrew); Northstone, K. (Kate); O'Rahilly, S. (Stephen); Purmann, C. (Carolin); Rees, M.G. (Matthew); Ridderstråle, M. (Martin); Ring, S.M. (Susan); Rivadeneira Ramirez, F. (Fernando); Ruokonen, A. (Aimo); Sandhu, M.S. (Manjinder); Saramies, J. (Jouko); Scott, L.J. (Laura); Scuteri, A. (Angelo); Silander, K. (Kaisa); Sims, M.A. (Matthew); Song, K. (Kijoung); Stephens, J. (Jonathan); Stevens, S. (Suzanne); Stringham, H.M. (Heather); Tung, Y.C.L. (Loraine); Valle, T.T. (Timo); Tikka-Kleemola, P. (Päivi); Vimaleswaran, K.S. (Karani); Vollenweider, P. (Peter); Waeber, G. (Gérard); Wallace, C. (Chris); Watanabe, R.M. (Richard); Waterworth, D. (Dawn); Watkins, N. (Nicholas); Witteman, J.C.M. (Jacqueline); Zeggini, E. (Eleftheria); Zhai, G. (Guangju); Zillikens, M.C. (Carola); Altshuler, D. (David); Caulfield, M. (Mark); Chanock, S.J. (Stephen); Farooqi, I.S. (Sadaf); Ferrucci, L. (Luigi); Guralnik, J.M. (Jack); Hattersley, A.T. (Andrew); Hu, F.B. (Frank); Jarvelin, M.R.; Laakso, M. (Markku); Mooser, V. (Vincent); Ong, K.K. (Ken); Ouwehand, W.H. (Willem); Salomaa, V. (Veikko); Samani, N.J. (Nilesh); Spector, T.D. (Timothy); Tuomi, T. (Tiinamaija); Tuomilehto, J. (Jaakko); Uda, M.; Uitterlinden, A.G. (André); Wareham, N.J. (Nicholas); Deloukas, P. (Panagiotis); Frayling, T.M. (Timothy); Groop, L. (Leif); Hayes, R.B. (Richard); Hunter, D. (David); Mohlke, K.L. (Karen); Peltonen, L. (Leena Johanna); Schlessinger, D. (David); Strachan, D.P. (David); Wichmann, H.E. (Erich); McCarthy, M.I. (Mark); Boehnke, M. (Michael); Barroso, I. (Inês); Abecasis, G.R. (Gonçalo); Hirschhorn, J.N. (Joel)
    In:Nature Genetics, 41(1), 25 - 34. ISSN 1061-4036.

    Abstract:

    Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000)

  • Long sleep duration is associated with serum cholesterol in the elderly: The rotterdam study (2008)

    Authors:Berg, van den J.F. (Julia); Miedema, H.M. (Henk); Tulen, J.H.M. (Joke); Neven, A.K.; Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline); Tiemeier, H. (Henning)
    In:Psychosomatic Medicine, 70(9), 1005 - 1011. ISSN 0033-3174.

    Abstract:

    Objective: Epidemiological studies have repeatedly found increased mortality associated with both habitual short and long sleep duration. The mechanisms behind these associations are unclear. We investigated whether objectively measured sleep duration, time in bed, and sleep fragmentation were assoc

  • Predicting type 2 diabetes based on polymorphisms from genome-wide association studies A population-based study (2008)

    Authors:Hoek, van M. (Mandy); Dehghan, A. (Abbas); Witteman, J.C.M. (Jacqueline); Tikka-Kleemola, P. (Päivi); Uitterlinden, A.G. (André); Oostra, B.A. (Ben); Hofman, A. (Albert); Sijbrands, E.J.G. (Eric); Janssens, A.C.J.W. (Cécile)
    In:Diabetes, 57(11), 3122 - 3128. ISSN 0012-1797.

    Abstract:

    OBJECTIVE-Prediction of type 2 diabetes based on genetic testing might improve identification of high-risk subjects. Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 di

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